A5100753798- Gastric Cancer Management and Outcomes
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related molecular mechanisms research
- Esophageal Cancer Research and Treatment
- Colorectal Cancer Treatments and Studies
- Colorectal Cancer Surgical Treatments
- Genetic factors in colorectal cancer
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Esophageal and GI Pathology
- RNA modifications and cancer
- Colorectal and Anal Carcinomas
- Cancer Genomics and Diagnostics
- Helicobacter pylori-related gastroenterology studies
- MicroRNA in disease regulation
- Pancreatic and Hepatic Oncology Research
- RNA Interference and Gene Delivery
- Ferroptosis and cancer prognosis
- Colorectal Cancer Screening and Detection
- Cancer Mechanisms and Therapy
- Extracellular vesicles in disease
- Cardiac, Anesthesia and Surgical Outcomes
- Peptidase Inhibition and Analysis
Peking University Cancer Hospital
2016-2025
Peking University
2016-2025
Shenyang Pharmaceutical University
2024-2025
Nanjing Medical University
2024-2025
Jiangsu Province Hospital
2024-2025
Sanofi (Germany)
2009-2025
Jilin Medical University
2025
Jilin University
2025
Northeast Agricultural University
2022-2025
Hebei University of Technology
2025
The safety and efficacy of radical laparoscopic distal gastrectomy (LG) with D2 lymphadenectomy for the treatment advanced gastric cancer (AGC) remain controversial. We conducted a randomized controlled trial to compare conventional open lymph node dissections AGC.Between September 2012 December 2014, 1,056 patients clinical stage T2-4aN0-3M0 were eligible inclusion. They randomly assigned either LG group (n = 528) or (OG) 528). Fifteen experienced surgeons from 14 institutions in China...
<h3>Importance</h3> Laparoscopic distal gastrectomy is accepted as a more effective approach to conventional open for early-stage gastric cancer. However, efficacy locally advanced cancer remains uncertain. <h3>Objective</h3> To compare 3-year disease-free survival patients with after laparoscopic or gastrectomy. <h3>Design, Setting, and Patients</h3> The study was noninferiority, open-label, randomized clinical trial at 14 centers in China. A total of 1056 eligible stage T2, T3, T4a without...
Abstract Messenger RNA (mRNA) vaccines are being used to combat the spread of COVID-19 (refs. 1–3 ), but they still exhibit critical limitations caused by mRNA instability and degradation, which major obstacles for storage, distribution efficacy vaccine products 4 . Increasing secondary structure lengthens half-life, which, together with optimal codons, improves protein expression 5 Therefore, a principled design algorithm must optimize both structural stability codon usage. However, owing...
<h3>Importance</h3> It is not clear whether laparoscopic and open distal gastrectomy produce similar outcomes among patients with locally advanced gastric cancer. Data from a multicenter, randomized clinical trial (Chinese Laparoscopic Gastrointestinal Surgical Study [CLASS]–01) showed that did result in inferior disease-free survival at 3 years compared gastrectomy. <h3>Objective</h3> To report 5-year overall data the CLASS-01 of vs <h3>Design, Setting, Patients</h3> This was...
Laparoscopic distal gastrectomy and neoadjuvant chemotherapy are increasingly used to treat locally advanced gastric cancer. However, the safety efficacy of laparoscopic procedure after remain unclear.
The discovery of antibiotics and pesticides has greatly contributed to the social economic development human society but, due long-term irrational application, it led drug-resistant microorganisms, environmental damage, other hazards, so selection alternative natural, safe, non-hazardous bioactive substances is an effective solution for this problem. D-limonene a compound widely present in various plant essential oils, exhibiting excellent broad-spectrum bioactivity promising prospects...
Oral squamous cell carcinoma (OSCC) is one of the most common malignant diseases worldwide, yet its molecular mechanisms are largely unknown. We aimed to construct gene co-expression networks identify key modules and hub genes involved in pathogenesis OSCC.We used dataset GSE30784 by weighted network analysis (WGCNA). Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analyses were performed Database for Annotation, Visualization Integrated Discovery (DAVID). Hub screened...
Identification of effective prognostic biomarkers and targets are crucial importance to the management estrogen receptor positive (ER+) breast cancer. CCNA2 (also known as CyclinA2) belongs highly conserved cyclin family is significantly overexpressed in various cancer types. In this study, we demonstrated that had significant predictive power distant metastasis free survival, disease recurrence survival overall ER+ patients. We also found was closely associated with tamoxifen resistance....
The programmed cell death-1 receptor/programmed ligand (PD-1/PD-L1) pathway plays a crucial role in tumor evasion from host immunity. This study was designed to evaluate the association between circulating PD-L1 expression and prognosis patients with advanced gastric cancer.Totally 80 cancer 40 health controls Beijing Cancer Hospital were enrolled present study. Circulating tested by enzyme-linked immunosorbent assay (ELISA). associations level of clinicopathological features analyzed...
We investigated the superiority of 8th edition tumor-node-metastasis (TNM) system for patients in China with gastric cancer.The survival outcomes 1663 cancer undergoing radical resection were analyzed.In system, homogeneous 5-year rates among different pathological TNM (pTNM) categories belonging to same stage observed. However, 7th differences rate pTNM observed stages IIB (P = 0.010), IIIB 0.004), and IIIC < 0.001). For pT1-3 0.001) pT4a categories, there significant between pN3a pN3b...
Background Neoadjuvant chemotherapy before radical gastrectomy is preferred for locally advanced gastric cancer. To avoid the problematic use of pTNM patients after neoadjuvant chemotherapy, Union International Cancer Control (UICC) and American Joint Committee on (AJCC) cancer TNM staging system (8th edition) added ypTNM first time. But achieving pathological complete response were not covered by new system. investigate whether associated with better outcome in cancer, as was reported...
Neoadjuvant chemotherapy is a common treatment for patients with gastric cancer. Although its benefits have been demonstrated, neoadjuvant underutilized in cancer management, because of the lack biomarkers patient selection and limited understanding resistance mechanisms. Here, we performed whole-genome, whole-exome, RNA sequencing on 84 clinical samples (including matched pre- posttreatment tumors) from 35 whose responses to were rigorously defined. We observed increased microsatellite...
The combination of immune checkpoint blockade and chemotherapy has revolutionized the treatment advanced gastric cancer (GC). It is crucial to unravel chemotherapy-induced tumor microenvironment (TME) modulation identify which immunotherapy would improve antitumor effect.
Background Systemic Immune-inflammation Index (SII) and body composition parameters are easily assessed, can predict overall survival (OS) in various cancers, allowing early intervention. This study aimed to assess the correlation between CT-derived SII OS patients with advanced gastric cancer receiving dual programmed death-1 (PD-1) human epidermal growth factor receptor 2 (HER2) blockade. Materials methods retrospective enrolled treated PD-1 HER2 blockade from March 2019 June 2022. We...