A5047589658- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Gastrointestinal disorders and treatments
- Cancer Immunotherapy and Biomarkers
- Sarcoma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Neurofibromatosis and Schwannoma Cases
- Immune Cell Function and Interaction
- Colorectal Cancer Treatments and Studies
- Inflammatory mediators and NSAID effects
- Cancer, Lipids, and Metabolism
- Platelet Disorders and Treatments
- Esophageal Cancer Research and Treatment
- Soft tissue tumor case studies
- Inflammatory Biomarkers in Disease Prognosis
- Cell Adhesion Molecules Research
- Nutrition and Health in Aging
- RNA Interference and Gene Delivery
- Radiomics and Machine Learning in Medical Imaging
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Lung Cancer Diagnosis and Treatment
- T-cell and B-cell Immunology
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
First Affiliated Hospital Zhejiang University
2016-2025
Zhejiang University
2012-2024
In-Q-Tel
2013
Peking University Shenzhen Hospital
2009
National Natural Science Foundation of China
2005
Peking University First Hospital
2003
Peking University
2003
327 Background: The optimal chemotherapeutic regimen for gastric cancer with peritoneal metastasis remains undefined. We evaluated the efficacy and safety of intraperitoneal intravenous paclitaxel plus S-1 (NIPS Group) versus (PS in patients metastasis. Methods: In this multicenter, randomized, controlled, phase 3 trial, were recruited from 9 centers China. Eligible aged 18~75 years an Eastern Cooperative Oncology Group performance status 0~1, histologically confirmed adenocarcinoma,...
Mitofusin-2 (Mfn2) is a mitochondrial outer membrane protein involved in fusion. Its mutation can cause Charcot-Marie-Tooth disease. Recent studies of Mfn2 cancer research have not included gastric cancer. We confirmed that expression was lower tumor tissue than normal mucosal and it negatively correlated with size, indicating an anti-tumor role for Mfn2. In vitro experiments showed overexpression suppressed cell proliferation colony formation, weakened the invasion migratory ability cells...
Regulatory T cells (Tregs) and plasmacytoid dendritic (p DC s) play important roles in the immune escape of cancer. In this study, we investigated p s ‐induced inducible costimulator ( ICOS ) + Treg populations peripheral blood from gastric cancer GC patients healthy donors by flow cytometry. The distribution these carcinoma tissue, peritumor normal mucosa was detected immunohistochemistry. Plasma tissue concentration cytokines such as interleukin‐10 transforming growth factor‐β1 were also...
Abstract Background Accurate predictors of survival for patients with advanced gastric cancer treated neoadjuvant chemotherapy are currently lacking. In this study, we aimed to evaluate the prognostic significance neutrophil-lymphocyte ratio (NLR) in stage III-IV who received chemotherapy. Methods We enrolled 46 study. The NLR was divided into two groups: high (>2.5) and low (≤2.5). Univariate analysis on progression-free (PFS) overall survival(OS) performed using Kaplan-Meier log-rank...
Resistance to chemotherapy is a major obstacle for the effective treatment of cancers. Lin28 has been shown contribute tumor relapse after chemotherapy; however, relationship between and chemoresistance remained unknown. In this study, we investigated association with paclitaxel resistance identified underlying mechanisms action in human breast cancer cell lines tissues. We found that expression level was closely associated treatment. The T47D line, which highly expresses Lin28, more...
Interleukin-17 (IL-17) is prevalent in tumor tissue and suppresses effective anti-tumor immune responses. However, the source of increased tumor-infiltrating IL-17 its contribution to progression human gastric cancer remain poorly understood. In this study, we enrolled 112 patients, immunofluorescence was used evaluate colocalization CD3, CD4, CD56, CD20, CD68, mast cell tryptase (MCT) with IL-17. Immunohistochemistry distribution microvessel density (CD34), CD66b+, CD68+, FoxP3+ cells...
Background: The leucine-rich repeat containing G protein-coupled receptor 5 (Lgr5) is considered a cancer stem cell marker, and often overexpressed in tumors. interaction between Lgr5 the immune-related tumor microenvironment not completely understood. aim of this study was to examine role gastric (GC), explore possible immunological mechanisms influencing expression that are governed by regulatory T cells. Methods: examined 180 GC tumors immunohistochemistry, 80 pairs for analysis Th1/Th2...
To investigate the expression and associations of putative stem cell markers with survival in patients locally advanced gastric cancer (GC) receiving neoadjuvant chemotherapy. This study included 180 GC who received chemotherapy subsequent radical gastrectomy between June 2010 December 2014. Surgical paraffin samples from enrolled were collected. Tissue microarrays used to detect patterns 10 markers; immunohistochemistry was evaluate CD133 SOX2 adjacent tissues. The prognostic values these...
Background:The prognostic nutritional index (PNI) is a useful parameter that indicates the immunonutritional status of patients with malignant tumors.In this retrospective study, we aimed to investigate value PNI predict outcome gastrointestinal stromal tumors (GISTs).Material and methods: This study enrolled 431 GIST who underwent curative resection from January 2000 December 2012.A receiver operating characteristic (ROC) curve analysis was used identify cutoff PNI, neutrophil lymphocyte...
Perioperative chemotherapy is a potential treatment for locally advanced gastric cancer. However, the optimal regimen remains unknown.To investigate safety and efficacy of S-1 plus oxaliplatin (SOX) vs fluorouracil, leucovorin, (FOLFOX) as perioperative patients with cancer.In this phase 3, open-label, multicenter, randomized clinical trial, from 12 Chinese hospitals were enrolled between June 2011 August 2016, last follow-up date September 2019. The primary tumor was evaluated either...
Gastrointestinal stromal tumors (GISTs) occur rarely in the duodenum. The characteristics of duodenal GIST have not been well clarified. aim this study is to clarify and surgical prognosis patients with primary GIST.Data surgically treated were retrospectively analyzed. Immunohistochemical expressions p53, p16, Ki-67 evaluated explain prognosis.Compared gastric or small intestinal GISTs historical studies, had a relatively smaller size, lower mitotic count, LI, p16 loss, similar p53...
Collagen VI is significant in the progression of numerous types cancer. Type collagen consists three α-chains and α3 (COL6A3) encodes chain. The overexpression COL6A3 has been demonstrated to correlate with high-grade ovarian cancer contributes cisplatin resistance; however, its role human gastric (GC) remains unclear. Using microarray meta-analysis, was observed be frequently overexpressed GC tissues, furthermore, this identified five cell lines. A microarray-based co-expression network...
Background: Regulatory T cells (Tregs) and plasmacytoid dendritic (pDCs) are the main immunosuppressive in tumor microenvironment of gastric cancer (GC). In this prospective study, association prognosis with Tregs subsets pDCs were further analyzed. Methods: pDCs, population its expression inducible costimulator (ICOS) analyzed peripheral blood from 41 GC patients by multicolor flow cytometry. These cell populations carcinoma tissue, peritumor tissue normal mucosa 87 also detected...
Variants of CD44 have been proposed to be important in promoting tumor progression and metastasis. We attempted determine the expression CD44v6 product advanced gastric cancer evaluate its prognostic value.The was analyzed immunohistochemically cancers using monoclonal antibody, 44-2V. investigated relationship between prognosis 201 patients.Ninety-five (47.3%) tissues expressed CD44v6. The protein significantly higher differentiated, adenocarcinoma than diffuse type carcinoma....
TGF-β plays a dual role in the progression of human cancer. During early stages carcinogenesis, functions as tumor suppressor. late development, however, can promote growth and metastasis. A shift Smad2/3 phosphorylation from carboxy terminus to linker sites is key event determining biological function colorectal hepatocellular carcinoma. In present study, we investigated potential differential gastric adenocarcinoma.Immunohistochemical staining with anti-P-Smad2/3C P-Smad2/3L antibodies was...
Aim: The role of neutrophil–lymphocyte ratio (NLR) and derived (d-NLR) in outcome prediction is assessed patients with advanced gastric cancer receiving preoperative chemotherapy a 5-year follow-up cohort. Patients methods: undergoing sequential R0 resection for were enrolled from July 2004 to November 2011. Wilcoxon matched-pairs signed-rank test was used evaluate the change peripheral blood parameters. Receiver operating curve identify optimal cutoff values NLR d-NLR. Survival function...
Plasmacytoid dendritic cells (pDCs) play a crucial role in the microenvironment of tumor. Evidences has been shown that chemokine receptor 9 (CCR9) is an important molecule attracts pDCs homing to digestive tract and latter are involved formation immune tolerance. The aim this study was explore CCR9-CCL25 interaction pDC-mediated immunosuppression gastric cancer (GC).Regulatory T (Tregs) were detected by immunohistochemistry. CCR9, which expressed on pDC visualized immunofluorescence....