A5054972918- Gastric Cancer Management and Outcomes
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Colorectal Cancer Treatments and Studies
- Esophageal Cancer Research and Treatment
- Cancer-related molecular mechanisms research
- Intraperitoneal and Appendiceal Malignancies
- Esophageal and GI Pathology
- Biochemical and Molecular Research
- Colorectal and Anal Carcinomas
- Peptidase Inhibition and Analysis
- Testicular diseases and treatments
- Genetic factors in colorectal cancer
- Immunotherapy and Immune Responses
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Food composition and properties
- Neuroendocrine Tumor Research Advances
- Ovarian cancer diagnosis and treatment
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Hepatocellular Carcinoma Treatment and Prognosis
- Seed and Plant Biochemistry
Peking University
2016-2025
Peking University Cancer Hospital
2016-2025
Shanxi Normal University
2023
State Key Laboratory of Food Science and Technology
2019-2022
Nanchang University
2019-2022
Zhejiang University
2020
Ministry of Education of the People's Republic of China
2019
Ministry of Education
2018
Dalian Medical University
2017
First Affiliated Hospital of Dalian Medical University
2017
T cells play a central role in cancer immunotherapy, but we lack systematic comparison of the heterogeneity and dynamics tumor-infiltrating across types. We built single-cell RNA-sequencing pan-cancer atlas for 316 donors 21 types revealed distinct cell composition patterns. found multiple state-transition paths exhaustion CD8+ preference those among different tumor Certain populations showed specific correlation with patient properties such as mutation burden, shedding light on possible...
The programmed cell death-1 receptor/programmed ligand (PD-1/PD-L1) pathway plays a crucial role in tumor evasion from host immunity. This study was designed to evaluate the association between circulating PD-L1 expression and prognosis patients with advanced gastric cancer.Totally 80 cancer 40 health controls Beijing Cancer Hospital were enrolled present study. Circulating tested by enzyme-linked immunosorbent assay (ELISA). associations level of clinicopathological features analyzed...
Neoadjuvant chemotherapy is a common treatment for patients with gastric cancer. Although its benefits have been demonstrated, neoadjuvant underutilized in cancer management, because of the lack biomarkers patient selection and limited understanding resistance mechanisms. Here, we performed whole-genome, whole-exome, RNA sequencing on 84 clinical samples (including matched pre- posttreatment tumors) from 35 whose responses to were rigorously defined. We observed increased microsatellite...
We investigated the superiority of 8th edition tumor-node-metastasis (TNM) system for patients in China with gastric cancer.The survival outcomes 1663 cancer undergoing radical resection were analyzed.In system, homogeneous 5-year rates among different pathological TNM (pTNM) categories belonging to same stage observed. However, 7th differences rate pTNM observed stages IIB (P = 0.010), IIIB 0.004), and IIIC < 0.001). For pT1-3 0.001) pT4a categories, there significant between pN3a pN3b...
The objective of this study is to evaluate the efficiency and safety carbon nanoparticles (CNPs) for harvesting lymph nodes (LNs) in cases advanced gastric cancer (AGC). Patients with previously untreated resectable AGC were eligible inclusion study. All patients randomly allocated two subgroups. In experimental group, 1.0 mL CNP was injected into subserosa stomach around tumor before gastrectomy D2 dissection. same procedure performed directly without any coloring material control arm....
This study was designed to evaluate the impact of postoperative major complications on long-term survival following curative gastrectomy. retrospective included 239 patients with gastric cancer undergoing gastrectomy at Beijing Cancer Hospital from February 2012 January 2013. Survival curves were compared between (mC group) and those without (NmC group). Multivariate analysis conducted identify independent prognostic factors. Postoperative complication mortality rates 24.7 0.8%,...
Early gastric cancer is defined as a lesion confined to the mucosa or submucosa, regardless of size lymph node metastasis. Treatment methods include endoscopic mucosal resection submucosal dissection, wedge resection, laparoscopically assisted gastrectomy and open gastrectomy. Lymph metastasis strong related with survival recurrence. Therefore, likelihood one most important factors when determining appropriate treatment.We retrospectively analyzed 597 patients who underwent D2 for early...
Abstract Background HIPEC is an emerging procedure to treat peritoneal metastasis of gastric cancer. Data about in locally advanced cancer scarce. The purpose this trial evaluate the safety and toxicity prophylactic with cisplatin for patients Methods From March 2015 November 2016, a prospective, randomized phase II was conducted. After radical gastrectomy, experimental group underwent followed by adjuvant chemotherapy SOX regime. Patients other were treated regime alone. Postoperative...
The trial was designed to evaluate the efficacy of prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) with cisplatin for patients locally advanced gastric cancer (LAGC). Between March 2015 and November 2016, a phase II clinical performed. Fifty consecutive LAGC were randomly assigned two groups: experimental group (radical gastrectomy + HIPEC adjuvant chemotherapy) control chemotherapy). Survival rates closely monitored. 5-year overall survival (OS) rate all 80.0%. OS in lower...
The prognosis for ovarian metastasis of gastric cancer is poor. There no currently available treatment this disease. purpose study was to evaluate the efficacy and safety hyperthermic intraperitoneal chemotherapy (HIPEC) after cytoreductive surgery (CRS) in female patients with metachronous metastasis. From January 2000 December 2010, 62 developed undergoing gastrectomy D2 lymphadenectomy. Thirty-two underwent CRS plus HIPEC, 30 alone. median age all 44 years (range 19-71 years). Metastatic...
Schwannomas are tumors arising from the nervous system that also occur infrequently in gastrointestinal tract, most commonly stomach. This report characterizes 29 patients with benign or malignant gastric schwannomas. Surgical data and clinical follow-up information were available for 28 cases a median postoperative duration of 57 months. Clinicopathological immunohistochemical characteristics schwannomas analysed. Four (13.7%) histologically diagnosed schwannoma. All positive S-100 CD56...
Abstract Xenotransplantation of human cancers into immunodeficient mice is a very useful approach for studying tumor biology. However, the occasional occurrence lymphomagenesis in some can spoil model and must be investigated detail. We found that high percentage (32.5%, 26/80) cancer patient-derived xenografts (PDXs) resembled lymphoma NOD/SCID mice. Of 26 xenografts, 23 were human-derived expressing CD45 (hCD45+) proved to B-cell subtype (CD3-/CD20+) they all positive Epstein - Barr virus...
The optimal extent of gastrectomy for middle-third gastric cancer remains controversial. In our study, the short-term effects and longer-term survival outcomes distal subtotal total are analysed to determine cancer. We retrospectively collect analyse clinicopathologic data follow-up from a prospectively collected database at Peking University Cancer Hospital. Patients with adenocarcinoma who underwent curative resection enrolled in study. 339 patients between January 2005 October 2011. A 144...
This study assessed the postoperative morbidity and mortality occurring in first 30 days after radical gastrectomy by comparing gastric cancer patients who did or not receive FOLFOX7 regimen of neoadjuvant chemotherapy.We completed a retrospective analysis 377 their gastrectomies were performed our department between 2005 2009. Two groups studied: SURG group received surgical treatment immediately diagnosis; NACT underwent surgery 2-6 cycles chemotherapy.There 267 110 group. The had more...
The aim of the present study was to compare difference between double tract reconstruction and esophagogastrostomy.Patients who underwent radical proximal gastrectomy with esophagogastrostomy or were included in this study.Sixty-four patients divided into two groups according method. well balanced perioperative safety 3-year overall survival (OS). rates postoperative reflux esophagitis group 8.0% 30.8%, respectively (p=0.032). Patients had a better global health status (p < 0.001) emotional...
Abstract Background Although the role of peri‐operative chemotherapy is established in treatment locally advanced gastric cancer, optimal regime remains to be determined. FOLFOX has been used palliative setting with good response rates but its a neoadjuvant not well established. Methods This prospective non‐randomized study comparing versus adjuvant patients resectable cancer. Response was assessed according WHO criteria and pathological changes. Kaplan–Meier log rank test calculate compare...