Jianmin Wu
A5068746343- Cancer Genomics and Diagnostics
- Pancreatic and Hepatic Oncology Research
- Chinese history and philosophy
- Epigenetics and DNA Methylation
- Bioinformatics and Genomic Networks
- Digital Media and Visual Art
- Natural Language Processing Techniques
- Cancer-related gene regulation
- Cancer, Hypoxia, and Metabolism
- Wikis in Education and Collaboration
- Language, Metaphor, and Cognition
- Genomics and Phylogenetic Studies
- Cancer-related molecular mechanisms research
- Cancer-related Molecular Pathways
- Ubiquitin and proteasome pathways
- Biomedical Text Mining and Ontologies
- DNA Repair Mechanisms
- Pancreatic function and diabetes
- Advanced Proteomics Techniques and Applications
- RNA modifications and cancer
- Sirtuins and Resveratrol in Medicine
- Soil Mechanics and Vehicle Dynamics
- Neuroendocrine Tumor Research Advances
- Chromosomal and Genetic Variations
- Cancer Cells and Metastasis
Peking University
2016-2025
Peking University Cancer Hospital
2016-2025
Peking University International Hospital
2020-2025
Chinese Academy of Sciences
2024
Fujian Medical University
2024
First Affiliated Hospital of Fujian Medical University
2024
Jiangnan University
2024
Garvan Institute of Medical Research
2013-2023
UNSW Sydney
2013-2023
Wenzhou Medical University
2006-2022
High-throughput experimental technologies often identify dozens to hundreds of genes related to, or changed in, a biological pathological process. From these one wants pathways that may be involved and diseases implicated. Here, we report web server, KOBAS 2.0, which annotates an input set with putative disease relationships based on mapping known annotations. It allows for both ID cross-species sequence similarity mapping. then performs statistical tests statistically significantly enriched...
There is an increasing need to automatically annotate a set of genes or proteins (from genome sequencing, DNA microarray analysis protein 2D gel experiments) using controlled vocabularies and identify the pathways involved, especially statistically enriched pathways. We have previously demonstrated KEGG Orthology (KO) as effective alternative vocabulary developed standalone KO-Based Annotation System (KOBAS). Here we report KOBAS server with friendly web-based user interface enhanced...
The Protein Interaction Network Analysis (PINA) platform is a comprehensive web resource, which includes database of unified protein–protein interaction data integrated from six manually curated public databases, and set built-in tools for network construction, filtering, analysis visualization. second version PINA enhances its utility studies protein interactions at level, by including multiple collections modules identified different clustering approaches the whole ('interactome') model...
The importance of epigenetic modifications such as DNA methylation in tumorigenesis is increasingly being appreciated. To define the genome-wide pattern pancreatic ductal adenocarcinomas (PDAC), we captured profiles 167 untreated resected PDACs and compared them to a panel 29 adjacent nontransformed pancreata using high-density arrays. A total 11,634 CpG sites associated with 3,522 genes were significantly differentially methylated (DM) PDAC capable segregating from non-malignant pancreas,...
Inter- and intra-tumor heterogeneity is a major hurdle in primary liver cancer (PLC) precision therapy. Here, we establish PLC biobank, consisting of 399 tumor organoids derived from 144 patients, which recapitulates histopathology genomic landscape parental tumors, reliable for drug sensitivity screening, as evidenced by both vivo models patient response. Integrative analysis dissects heterogeneity, regarding genomic/transcriptomic characteristics to seven clinically relevant drugs, well...
Coordinated efforts to collect large-scale data sets provide a basis for systems level understanding of complex diseases. In order translate these fragmented and heterogeneous into knowledge medical benefits, advanced computational methods analysis, integration visualization are needed.We introduce novel framework, Anduril, translating testable predictions. The Anduril framework allows rapid with state-of-the-art existing in bio-databases. automatically generates thorough summary reports...
Purpose Individuals with adenocarcinoma of the ampulla Vater demonstrate a broad range outcomes, presumably because these cancers may arise from any one three epithelia that converge at location. This variability poses challenges for clinical decision making and development novel therapeutic strategies. Patients Methods We assessed potential utility histomolecular phenotypes defined using combination histopathology protein expression (CDX2 MUC1) in 208 patients independent cohorts who...
<h3>Objective</h3> Pancreatic cancer is a leading cause of cancer-related death in the Western world. Current chemotherapy regimens have modest survival benefit. Thus, novel, effective therapies are required for treatment this disease. <h3>Design</h3> Activating <i>KRAS</i> mutation almost always drives pancreatic tumour initiation, however, deregulation other potentially druggable pathways promotes progression. PTEN loss leads to acceleration <i>Kras<sup>G12D</sup></i>-driven ductal...
Pancreatic cancer is one of the most lethal and molecularly diverse malignancies. Repurposing therapeutics that target specific molecular mechanisms in different disease types offers potential for rapid improvements outcome. Although HER2 amplification occurs pancreatic cancer, it inadequately characterized to exploit anti-HER2 therapies.HER2 was detected further analyzed using multiple genomic sequencing approaches. Standardized reference laboratory assays defined a large cohort patients (n...
Pancreatic ductal adenocarcinoma (PDAC) can be divided into transcriptomic subtypes with two broad lineages referred to as classical (pancreatic) and squamous. We find that these are driven by distinct metabolic phenotypes. Loss of genes drive endodermal lineage specification, HNF4A GATA6, switch profiles from predominantly squamous, glycogen synthase kinase 3 beta (GSK3β) a key regulator glycolysis. Pharmacological inhibition GSK3β results in selective sensitivity the squamous subtype;...
Neoadjuvant chemotherapy is a common treatment for patients with gastric cancer. Although its benefits have been demonstrated, neoadjuvant underutilized in cancer management, because of the lack biomarkers patient selection and limited understanding resistance mechanisms. Here, we performed whole-genome, whole-exome, RNA sequencing on 84 clinical samples (including matched pre- posttreatment tumors) from 35 whose responses to were rigorously defined. We observed increased microsatellite...
In prostate cancer, cancer-associated fibroblasts (CAF) exhibit contrasting biological properties to non-malignant (NPF) and promote tumorigenesis. Resolving intercellular signaling pathways between CAF tumor epithelium may offer novel opportunities for research translation. To this end, the proteome phosphoproteome of four pairs patient-matched NPF were characterized identify discriminating proteomic signatures. Samples analyzed by liquid chromatography-tandem mass spectrometry (LC-MS/MS)...
Tumour cellularity, the relative proportion of tumour and normal cells in a sample, affects sensitivity mutation detection, copy number analysis, cancer gene expression methylation profiling. cellularity is traditionally estimated by pathological review sectioned specimens; however this method both subjective prone to error due heterogeneity within lesions differences between sample viewed during tissue used for research purposes. In paper we describe statistical model estimate from SNP...
Metastasis, the leading cause of cancer death, requires tumor cell intravasation, migration through bloodstream, arrest within capillaries, and extravasation to invade distant tissues. Few mechanistic details have been reported thus far regarding process or re-entry circulating cells at metastatic sites. Here, we show that neuropilin-2 (NRP-2), a multifunctional nonkinase receptor for semaphorins, vascular endothelial growth factor (VEGF), other factors, expressed on interacts with α5...