Grant A. McGregor
A5036245473- DNA Repair Mechanisms
- Pancreatic and Hepatic Oncology Research
- Genomic variations and chromosomal abnormalities
- Genomics and Chromatin Dynamics
- Epigenetics and DNA Methylation
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Genetics and Neurodevelopmental Disorders
- RNA Interference and Gene Delivery
- DNA and Nucleic Acid Chemistry
- RNA and protein synthesis mechanisms
- Advanced biosensing and bioanalysis techniques
- Renal and related cancers
- Plant Disease Resistance and Genetics
- Pancreatic function and diabetes
- BRCA gene mutations in cancer
- Polyomavirus and related diseases
Cancer Research UK Scotland Institute
2019-2020
Cancer Research UK
2019-2020
University of Sussex
2016-2017
Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set become second leading cause of death in our society. The study aim was investigate association between DNA damage response (DDR), replication stress, and novel therapeutic PC develop a biomarker-driven strategy targeting DDR stress PC.
Pancreatic ductal adenocarcinoma (PDAC) can be divided into transcriptomic subtypes with two broad lineages referred to as classical (pancreatic) and squamous. We find that these are driven by distinct metabolic phenotypes. Loss of genes drive endodermal lineage specification, HNF4A GATA6, switch profiles from predominantly squamous, glycogen synthase kinase 3 beta (GSK3β) a key regulator glycolysis. Pharmacological inhibition GSK3β results in selective sensitivity the squamous subtype;...
The structural maintenance of chromosomes (SMC) family proteins supports mitotic proliferation, meiosis, and DNA repair to control genomic stability. Impairments in chromosome are linked rare breakage disorders. Here, we have identified a syndrome associated with severe lung disease early childhood. Four children from two unrelated kindreds died pulmonary during infancy following viral pneumonia evidence combined T B cell immunodeficiency. Whole exome sequencing revealed biallelic missense...
Abstract The Structural Maintenance of Chromosomes (SMC) complexes: cohesin, condensin and Smc5/6 are involved in the organization higher-order chromosome structure—which is essential for accurate duplication segregation. Each complex scaffolded by a specific SMC protein dimer (heterodimer eukaryotes) held together via their hinge domains. Here we show that Smc5/6-hinge, like those cohesin condensin, also forms toroidal structure but with distinctive subunit interfaces absent from other...
ABSTRACT Continuing recalcitrance to therapy cements pancreatic cancer (PC) as the most lethal malignancy, which is set become second leading cause of death in our society. We interrogated transcriptome, genome, proteome and functional characteristics 61 novel PC patient-derived cell lines define therapeutic strategies targeting DNA damage response (DDR) replication stress. show that faithfully recapitulate epithelial component tumors including previously described molecular subtypes....
The identification of molecularly defined subgroups Pancreatic ductal Adenocarcinoma (PDAC) has the potential to transform clinical practice. There is now a growing consensus that PDAC can be divided into transcriptomic subtypes with 2 broad linages referred as Classical (Pancreatic) and Squamous. We find these two are driven by distinct metabolic phenotypes. Loss genes drive endodermal linage specification, HNF4A GATA6, switch profiles from predominantly Squamous, GSK3B key regulator...