A5056349566- Biochemical and Structural Characterization
- Estrogen and related hormone effects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Prostate Cancer Treatment and Research
- Hormonal and reproductive studies
- Peptidase Inhibition and Analysis
- Schizophrenia research and treatment
- Phytochemical compounds biological activities
- Chemical Synthesis and Analysis
- Glutathione Transferases and Polymorphisms
- Mass Spectrometry Techniques and Applications
- Functional Brain Connectivity Studies
- Genomics, phytochemicals, and oxidative stress
- Reproductive tract infections research
- Transgenic Plants and Applications
- HER2/EGFR in Cancer Research
- Breast Cancer Treatment Studies
- Protease and Inhibitor Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Mental Health and Psychiatry
- Biochemical and Molecular Research
- Mitochondrial Function and Pathology
- Menopause: Health Impacts and Treatments
- Retinoids in leukemia and cellular processes
- Antimicrobial Peptides and Activities
Queensland University of Technology
2015-2025
University of Wisconsin–Milwaukee
2024
King's College London
2015-2023
Abu Dhabi National Oil (United Arab Emirates)
2021
Maimonides Medical Center
2017
Cancer Research UK
1992-2016
University of Edinburgh
2004-2009
Royal Edinburgh Hospital
2003-2008
NHS Lothian
2007
Memorial Sloan Kettering Cancer Center
2006
Abstract There is emerging evidence that the balance between estrogen receptor-α (ERα) and androgen receptor (AR) signaling a critical determinant of growth in normal malignant breast. In this study, we assessed AR status cohort 215 invasive ductal breast carcinomas. ERα were coexpressed majority (80-90%) tumor cells. Kaplan-Meier product limit analysis multivariate Cox regression showed an independent prognostic factor ERα-positive disease, with low level (less than median 75% positive...
Cytosolic glutathione S-transferases (GSTs) are a supergene family of dimeric enzymes capable detoxifying number carcinogenic electrophiles. Of the numerous components tobacco smoke, polycyclic aromatic hydrocarbons appear to be principal compounds that yield substrates for these enzymes, GSTM1-1 being effective with those PAH derivatives so far studied; however, gene locus GSTM1 is polymorphic, containing two well-characterized expressing genes and null allele. Use cDNA or appropriate...
Recent evidence demonstrates that the androgen receptor (AR) continues to influence prostate cancer growth despite medical therapies reduce circulating ligands castrate levels and/or block ligand binding. Whereas mutation, amplification, overexpression of AR, or cross-talk between AR and other factor pathways may explain failure ablation in some cases, there is little supporting a causal role cancer. In this study, we functionally directly address whereby contributes spontaneous progression...
Whole-genome sequencing (WGS) is a powerful method for revealing the diversity and complexity of somatic mutation burden tumours. Here, we investigated utility tumour matched germline WGS understanding aetiology treatment opportunities high-risk individuals with familial breast cancer.
NOR-1/NR4A3 is an “orphan member” of the nuclear hormone receptor superfamily. NOR-1 and its close relatives Nurr1 Nur77 are members NR4A subgroup receptors. Members induced through multiple signal transduction pathways. They have been implicated in cell proliferation, differentiation, T-cell apoptosis, chondrosarcomas, neurological disorders, inflammation, atherogenesis. However, mechanism transcriptional activation, coactivator recruitment, agonist-mediated activation remain obscure....
Summary Studies of face processing have begun to elucidate the brain regions involved in social cognition, which include frontal and temporal known be reduced volume schizophrenia. In this case-control study participants with schizophrenia (n=20) showed marked deficits their ability interpret cues from faces, those experiencing positive symptoms were impaired recognising even basic facial emotions.
Genome-wide association studies (GWAS) have identified more than 30 prostate cancer (PrCa) susceptibility loci. One of these (rs2735839) is located close to a plausible candidate gene, KLK3, which encodes prostate-specific antigen (PSA). PSA widely used as biomarker for PrCa detection and disease monitoring. To refine the between variants in this region, we genotyping data from two-stage GWAS using samples UK Australia, Cancer Genetic Markers Susceptibility (CGEMS) study. Genotypes were...
Microplastics contamination has been widely reported in filter feeders yet the < 1 μm size fraction largely ignored. In attempt to characterize this sub and better understand distribution of microplastics feeders, field deployed oysters were characterised using a combination fractionation combined with pyrolysis-gas chromatography-mass spectrometry (Py-GC/MS) as well Fourier Transform-Infrared Spectroscopy (μFT-IR). Sequential filtration followed by Py-GC/MS identified 1–22 contain highest...
The androgen receptor (AR), a member of the steroid superfamily nuclear transcription factors, mediates signaling in diverse target tissues. Here we report AR gene mutations identified human prostate cancer and autochthonous transgenic adenocarcinoma mouse model that colocate to residues 668QPIF671 at boundary hinge ligand-binding domain, resulting receptors exhibit 2- 4-fold increased activity compared with wild-type response dihydrotestosterone, estradiol, progesterone, adrenal androgens,...
We have used the autochthonoustransgenic adenocarcinoma of mouseprostate (TRAMP) model to investigate relationship between somatic mutation in androgen receptor (AR) and emergence androgen-independent prostate cancer. Here we report identification, isolation, characterization distinct classes AR variants from spontaneous tumors TRAMP model. Using cDNA cloning, single stranded conformation polymorphism sequencing strategies, 15 unique mutations were identified obtained eight mice 24 29 weeks...
A rat liver mitochondrial-matrix fraction was prepared and shown to have 1-chloro-2,4-dinitrobenzene(CDNB)-metabolizing glutathione transferase (GST) activity. Further fractionation by sequential gel filtration, isoelectric focusing or chromatofocusing hydroxyapatite chromatography yielded three GSTs of pI 9.3, 8.9 7.5, none which bound a GSH-agarose affinity matrix. Most the activity associated with pI-9.3 form, selected for further study. Its tested following potential substrates in...
Abstract Although the androgen receptor (AR) is accepted as major determinant of prostate cancer cell survival throughout disease progression, it currently unclear how sustains genomic signaling under conditions systemic ablation. Here, we show that evolutionarily conserved Hsp70/Hsp90 cochaperone, small glutamine–rich tetratricopeptide repeat containing protein α (αSGT), interacts with hinge region human AR in yeast and mammalian cells. Overexpression RNA interference revealed αSGT acts to...