A5049501797- Pancreatic and Hepatic Oncology Research
- Pancreatitis Pathology and Treatment
- Neuroendocrine Tumor Research Advances
- Cancer Genomics and Diagnostics
- Gallbladder and Bile Duct Disorders
- Lung Cancer Research Studies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Renal cell carcinoma treatment
- Esophageal and GI Pathology
- Neuroblastoma Research and Treatments
- Gastric Cancer Management and Outcomes
- Gastrointestinal disorders and treatments
- Colorectal Cancer Screening and Detection
- Cancer Diagnosis and Treatment
- Gastrointestinal Tumor Research and Treatment
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- Thyroid Cancer Diagnosis and Treatment
- Cancer, Stress, Anesthesia, and Immune Response
- Metastasis and carcinoma case studies
- Colorectal Cancer Surgical Treatments
- Hepatocellular Carcinoma Treatment and Prognosis
- Endometriosis Research and Treatment
- Intestinal and Peritoneal Adhesions
- Uterine Myomas and Treatments
Vita-Salute San Raffaele University
2016-2025
Istituti di Ricovero e Cura a Carattere Scientifico
2016-2025
San Raffaele University of Rome
2004-2025
Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele
2016-2025
IRCCS Ospedale San Raffaele
2016-2025
University of Milano-Bicocca
2003-2024
Italian Association for Cancer Research
2024
Azienda Ospedaliera San Gerardo
2023-2024
Pancreas Centre (Canada)
2017-2023
Mayo Clinic
2023
In Brief Objective: Mucinous cystic neoplasms (MCNs) of the pancreas have often been confused with intraductal papillary mucinous neoplasms. We evaluated clinicopathologic characteristics, prevalence cancer, and prognosis a large series well-characterized MCNs in 2 tertiary centers. Methods: Analysis 163 patients resected MCNs, defined by presence ovarian stroma lack communication main pancreatic duct. Results: were seen mostly women (95%) distal (97%); 25% incidentally discovered....
The role of surgically placed intra-abdominal drainages after pancreatic resections has not been clearly established. In particular, their effect on morbidity rates and the optimal timing for removal remains controversial.A total 114 eligible patients who underwent standard at low risk postoperative fistula according to our institutional protocol (amylase value in drains < or =5000 U/L day [POD] 1) were randomized POD 3 receive either early (POD 3) drain 5 beyond). primary end point study...
<h3>Objectives</h3> Serous cystic neoplasm (SCN) is a of the pancreas whose natural history poorly known. The purpose study was to attempt describe SCN, including specific mortality. <h3>Design</h3> Retrospective multinational SCN diagnosed between 1990 and 2014. <h3>Results</h3> 2622 patients were included. Seventy-four per cent women, median age at diagnosis 58 years (16–99). Patients presented with non-specific abdominal pain (27%), pancreaticobiliary symptoms (9%), diabetes mellitus...
The correlation of the amylase value in drains (AVD) with development pancreatic fistula (PF) is still unclear.The purpose this study was to identify within first postoperative day (POD1) predictive role different risks factors, including AVD, PF.We prospectively investigated 137 patients who underwent major resections. PF defined and graded accordance International Study Group on considered 101 pancreaticoduodenectomies 36 distal overall incidence (A, B, C grades) 19.7% it 14.8% after...
The importance of epigenetic modifications such as DNA methylation in tumorigenesis is increasingly being appreciated. To define the genome-wide pattern pancreatic ductal adenocarcinomas (PDAC), we captured profiles 167 untreated resected PDACs and compared them to a panel 29 adjacent nontransformed pancreata using high-density arrays. A total 11,634 CpG sites associated with 3,522 genes were significantly differentially methylated (DM) PDAC capable segregating from non-malignant pancreas,...
Objective To evaluate mid-term outcomes and predictors of survival in non-operated patients with pancreatic intraductal papillary mucinous neoplasms (IPMNs) worrisome features or high-risk stigmata as defined by International Consensus Guidelines for IPMN. Reasons non-surgical options were physicians’ recommendation, patient personal choice comorbidities precluding surgery. Methods In this retrospective, multicentre analysis, IPMNs classified branch duct (BD) main (MD), the latter including...
Pancreatic cysts are common and often pose a management dilemma, because some precancerous, whereas others have little risk of developing into invasive cancers. We used supervised machine learning techniques to develop comprehensive test, CompCyst, guide the patients with pancreatic cysts. The test is based on selected clinical features, imaging characteristics, cyst fluid genetic biochemical markers. Using data from 436 cysts, we trained CompCyst classify as those who required surgery,...
Branch-duct intraductal papillary mucinous neoplasms (BD-IPMNs) of the pancreas are reported to be less aggressive than main-duct type. Hence, treatment has been proposed for former.To evaluate effectiveness a follow-up protocol BD-IPMNs.Prospective study.An academic tertiary referral centre.From 2000 2003, 109 patients with BD-IPMNs underwent trans-abdominal ultrasound and magnetic resonance cholangiopancreatography secretin. Patients who presented malignancy-related parameters (size >3.5...
Abstract Background Pancreatic resections for benign diseases may lead to long-term endocrine/exocrine impairment. The aim of this study was compare postoperative and results after different pancreatic disease. Methods Between 1990 1999, 62 patients underwent pancreaticoduodenectomy (PD), 36 atypical resection (AR) 64 left pancreatectomy (LP) tumours. Exocrine endocrine function evaluated by 72-h faecal chymotrypsin oral glucose tolerance test. Results incidence fistula significantly higher...
To evaluate the indications, perioperative, and long-term outcomes of a large cohort patients who underwent middle pancreatectomy (MP).MP is parenchyma-sparing technique aimed to reduce risk postoperative exocrine endocrine insufficiency. Reported after MP are conflicting.: Patients between 1990 2005 at Massachusetts General Hospital University Verona were identified. The compared with control group that extended left (ELP) for neoplasms in mid pancreas.A total 100 MP. most common...
Abstract Background Standard resections for benign and borderline neoplasms of the pancreas are associated with a significant risk long-term functional impairment, whereas enucleation preserves healthy parenchyma pancreatic function. The aim this study was to evaluate postoperative oncological results after enucleation. Methods Data collected prospectively from 61 consecutive patients who underwent were analysed. Results There no deaths. A clinically fistula reported in 14 (23 per cent),...
Nonfunctioning pancreatic neuroendocrine tumors (NF-PanNETs) are often indolent neoplasms without lymph node (LN) metastasis at diagnosis. Therefore, in patients with low risk of LN metastasis, the extent surgery and lymphadenectomy could be limited follow-up adjusted to very relapse.To construct a predicting model assess pN+ prior surgical resection for NF-PanNETs using preoperative retrievable variables.Retrospective review multiple logistic regression analysis predictive based on...
Purpose Individuals with adenocarcinoma of the ampulla Vater demonstrate a broad range outcomes, presumably because these cancers may arise from any one three epithelia that converge at location. This variability poses challenges for clinical decision making and development novel therapeutic strategies. Patients Methods We assessed potential utility histomolecular phenotypes defined using combination histopathology protein expression (CDX2 MUC1) in 208 patients independent cohorts who...
KRAS mutations represent the main cause of resistance to anti-epidermal growth factor receptor (EGFR) monoclonal antibodies (MoAbs) in metastatic colorectal cancer (mCRC). We evaluated whether highly sensitive methods for investigation improve accuracy predictions anti-EGFR MoAbs efficacy.We retrospectively objective tumor responses mCRC patients treated with cetuximab or panitumumab. codons 12 and 13 were examined by direct sequencing, MALDI-TOF MS, mutant-enriched PCR, engineered which...