A5100329635- Lymphoma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Viral-associated cancers and disorders
- Cancer Genomics and Diagnostics
- Cancer Immunotherapy and Biomarkers
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- Lung Cancer Treatments and Mutations
- Immune Cell Function and Interaction
- CNS Lymphoma Diagnosis and Treatment
- Ovarian cancer diagnosis and treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Research and Treatments
- Breast Cancer Treatment Studies
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- Mitochondrial Function and Pathology
- Histone Deacetylase Inhibitors Research
- Amino Acid Enzymes and Metabolism
- Epigenetics and DNA Methylation
- Fibroblast Growth Factor Research
Hubei University of Medicine
2023-2025
Taihe Hospital
2023-2025
Xijing Hospital
2024
Qujiang People's Hospital
2024
Guangdong Provincial People's Hospital
2024
Affiliated Eye Hospital of Wenzhou Medical College
2024
Wenzhou Medical University
2022-2024
Shanghai Medical College of Fudan University
2024
Karamay Central Hospital of Xinjiang
2024
Air Force Medical University
2024
Abstract The prognosis of advanced oral squamous cell carcinoma (OSCC) patients remains dismal and a better understanding the underlying mechanisms is critical for identifying effective targets with therapeutic potential to improve survival OSCC. This study aims clarify clinical biological significance metastasis-associated long non-coding RNA, lung adenocarcinoma transcript 1 (MALAT1) in We found that MALAT1 overexpressed OSCC tissues compared normal mucosa by real-time PCR. served as new...
Inter- and intra-tumor heterogeneity is a major hurdle in primary liver cancer (PLC) precision therapy. Here, we establish PLC biobank, consisting of 399 tumor organoids derived from 144 patients, which recapitulates histopathology genomic landscape parental tumors, reliable for drug sensitivity screening, as evidenced by both vivo models patient response. Integrative analysis dissects heterogeneity, regarding genomic/transcriptomic characteristics to seven clinically relevant drugs, well...
Thousands die each year from sudden infant death syndrome (SIDS). Neither the cause nor basis for varied prevalence in different populations is understood. While 2 cases have been associated with mutations type Vα, cardiac voltage-gated sodium channels (SCN5A), “Back to Sleep” campaign has decreased SIDS prevalence, consistent a role environmental influences disease pathogenesis. Here we studied SCN5A African Americans. Three of 133 were homozygous variant S1103Y. Among controls, 120 1,056...
Background Targeting the PD-1/PD-L1/L2 (programmed cell death protein 1/programmed ligand 1/ligand 2) pathway combined with other immunosuppressive signalings, such as CD73/A2aR (A2a adenosine receptor) signaling, has emerged a promising strategy for cancer treatment. The genetic characteristics of these immune checkpoints need to be further investigated in diffuse large B-cell lymphoma (DLBCL). Methods We performed whole-exome sequencing/targeted deep sequencing investigate and CD73/A2aR....
Background Gastric cancer (GC) remains a leading cause of cancer-related mortality, with over one million new cases and 769,000 deaths reported in 2020. Despite advancements chemotherapy, surgery, targeted therapies, delayed diagnosis due to overlooked early symptoms leads poor prognosis. Methods We integrated bulk RNA sequencing single-cell datasets from TCGA, GEO, OMIX001073, employing normalization, batch effect correction, dimensionality reduction methods identify key cell populations...
Epigenetic modifications contribute to lymphomagenesis. Here, we performed an expression clustering analysis and identified two epigenetic-related clusters (EC1 EC2). EC1 presented abundant TP53, MYD88, HIST1H1D, HIST1H1C, KMT2D EZH2 mutations inferior prognosis. Pathways involved in the regulation of DNA methylation/demethylation, histone methyltransferase activity, protein activity were significantly enriched EC1. However, EC2 was frequently accompanied by B2M, CD70 MEF2B mutations, which...
Background To assess predictive value of short-term choroidal changes for future myopic shift in children. Methods 577 eyes 289 primary school children were prospectively followed 2 years. Cycloplegic refractions at baseline, 1 year and years, measurements by optical coherence tomography baseline 3 months, used analyses. Myopic was defined as refraction change least −0.50 dioptre/year, years compared with baseline. Results 228 participants (455 eyes) completed 2-year follow-up. Approximately...
Hypoxia is a characteristic feature of solid tumors, leading to malignant behavior. During this process, HIF family members (HIFs) and the NF-κB pathway are activated. In addition, hypoxia-associated factor (HAF) reported participate in regulation HIFs. However, precise relationship among HIFs, HAF bladder cancer (BC) remains unknown. current investigation, T24 BC cells were exposed hypoxia, or by plasmid transfection overexpress RelA (P65) demonstrate their roles. The results indicate that...
Abstract Immune checkpoints, including PD‐1/PD‐L1, play an important role in immunosuppression various malignancies. Elevated levels of soluble programmed death ligand 1 (sPD‐L1) are associated with worse prognosis multiple myeloma and diffuse large B cell lymphoma. Herein, the purpose this study is to investigate relationships between plasma sPD‐L1 clinical response peripheral T‐cell lymphoma (PTCL) patients. A total 37 PTCL patients 20 healthy volunteers were enrolled. Peripheral blood...
Bone scanning (BS), liver ultrasonography (LUS), and chest radiography (CXR) are commonly recommended for baseline staging in patients with newly diagnosed breast cancer. The purpose of this study is to demonstrate whether these tests indicated specific patient subpopulation based on clinical molecular subtype. A retrospective 5406 cancer was conducted identify differences occurrence metastasis subtypes. All had been evaluated by BS, LUS CXR at diagnosis. Complete information available 5184...
Tim-3 is a promising target for antitumor immunotherapy. A number of clinical trials are evaluating the efficacy anti-Tim-3 therapies as single agent or combinations in solid tumors and haematologic malignancies. However, there remains considerable lack data on signalling, especially genetic characteristics immune microenvironment, diffuse large B cell lymphoma (DLBCL). Herein, we identified three mutations galectin-9, major ligand Tim-3, six patients with DLBCL (6/188, 3.2%) that were not...
Epigenetics serve a key role in peripheral T cell lymphoma (PTCL). The purpose of the present study was to investigate clinical significance enhancer zeste homolog 2 (EZH2) and histone deacetylase 1 (HDAC1/2) expression PTCL. A total 82 patients were enrolled study, including 43 with PTCL not otherwise specified (PTCL-NOS), 10 angioimmunoblastic T-cell (AITL), 14 natural killer/T-cell (NK/TCL) 15 anaplastic large (ALCL). EZH2 HDAC1/2 detected by immunohistochemistry any correlations between...
Diffuse large B-cell lymphoma (DLBCL) is a highly heterogenous malignancy, early identification of patients for relapse remains challenging. The potential to non-invasively monitor tumour evolutionary dynamics DLBCL needs be further established. In the present study, 17 biopsy and 38 plasma samples from with high-intermediate/high-risk were evaluated at baseline. Longitudinal blood also collected during therapy. Circulating DNA (ctDNA) was analysed using targeted sequencing based on gene...
Death receptor-mediated extrinsic apoptosis system had been developed as a promising therapeutic strategy in clinical oncology, such TRAIL therapy. However, multiple studies have demonstrated that resistance is the biggest problem for disappointing trials despite preclinical success. Targeting cellular FLICE inhibitory protein (cFLIP) one of combinatorial therapies to overcome DR-mediated due its negative regulator apoptosis. E × 527 (Selisistat) specific inhibitor SIRT1 activity with safe...
Colon cancer is one of the most common in world. Doxorubicin (DOX) a classical anti-tumor drug which widely used treatment cancers, however, high toxicity limited its further clinical application. Thus, it urgent to find new drugs with low and efficiency treat colon cancer. Isoalantolactone (IATL), an isomeric sesquiterpene lactone isolated from plant inula helenium, has been reported have anti-cancer activity against variety cells. However, function IATL remains unclear. Here, we...
The role of N6-methyladenosine (m6A) modification in tumor microenvironment has rarely been explored follicular lymphoma (FL). To examine the m6A biological behavior, especially immune landscape FL, we utilized Gene Expression Omnibus database to determine expression signatures m6A-regulators by unsupervised clustering, and then condense into a risk score, which was validated an external cohort from Tianjin Medical University Cancer Institute Hospital. Finally, 16 351 FL patients were...
Wilms tumor (WT) is a widespread urologic in children. Ferroptosis, on the other hand, novel form of cell death associated with development. In this study, we aim to explore predictability ferroptosis-related biomarkers estimating prognosis WT patients.To determine link between gene expression and prognosis, first collected RNA sequencing data clinical information, involving 124 6 healthy tissue samples, from TARGET database. Next, screened information for long non-coding using Cox...