Bladder cancer (BCa) is the most common malignant disease of urinary tract system, yet etiology still poorly understood. Clinically, majority BCa patients progress to invasive at final stage, leading death. Previous investigations have demonstrated that matrix metal­loproteinases (MMPs) play irreplaceable roles in tumor cell extravasation and implantation. In addition, increasing numbers reports provide evidence MMPs, especially MMP2 MMP9 are monitored by various signal transduction pathways...

Abstract Males have a higher incidence of renal cell carcinoma (RCC) than females, but the reason for this gender difference is unknown. Addressing question, we report discovery an androgen receptor (AR)–induced HIF2α/VEGF signal that drives RCC progression. AR attenuation or augmentation in cells altered their proliferation, migration, and invasion multiple models vitro vivo. Mechanistic investigations revealed targeting inhibited migration by modulating signals at level mRNA protein...

G9a has been reported to highly express in bladder transitional cell carcinoma (TCC) and inhibition significantly attenuates proliferation, but the underlying mechanism is not fully understood. The present study aimed at examining potential role of autophagy anti-proliferation effect on TCC T24 UMUC-3 lines vitro. We found that both pharmaceutical genetical attenuated proliferation by MTT assay, Brdu incorporation assay colony formation assay. induced like morphology as determined...

Silibinin, a dietary cancer chemopreventive flavonoid from the seeds of milk thistle, has been reported to exhibit anti-metastatic effects on renal cell carcinoma (RCC), but mechanism underlying this phenomenon is not fully understood. The present study aimed at examining potential role autophagy in regulating silibinin-induced RCC cells. Using ACHN and 786-O cells as model system vitro, we found that silibinin treatment increased expression LC3-II, resulted formation autophagolysosome...

Although neo-adjuvant radiotherapy is generally successful in treatment of advanced prostate cancer, radioresistance still a major therapeutic problem many patients. In the current study, we investigated effects metformin (1,1-dimethylbiguanide hydrochloride), widely used antidiabetic drug, on tumor cell radiosensitivity cancer. Through clonogenic survival assays, found that enhanced cancer cells with dose enhancement factor. Moreover, irradiation subcutaneous C4-2 tumors mice treated...

Bladder cancer (BCa) is the most vital urogenital malignant disease worldwide, bringing huge economic and social burden every year. Clinically, BCa subdivided into superficial type invasive according to clinic-pathology, accompanied with different strategy of therapy. Number reports indicate that 10-30% will inevitable progress type, manifesting enhanced behavior compared original type. Regardless being an or progressed from BCa, chemotherapy (including adjuvant neo-adjuvant chemotherapy) in...

Although important progress has been made in elucidating the role of tumor microenvironment development bladder cancer, little is currently known regarding interactions with vascular endothelial cells (ECs) that promote cancer progression. In present study, it reported epidermal growth factor receptor ligands induced by upregulation (VEGF)‑A and VEGF‑C via VEGF (R)2/nuclear factor‑κB signaling pathway ECs, may trigger EGFR Furthermore, interaction between ECs enhanced EC recruitment though...

We evaluated the feasibility of Raman spectroscopy (RS) in diagnosis and prognosis castration-resistant prostate cancer (CRPC) patients with (PC).Raman spectra are detected from PC cell lines (LNCaP C4-2) tissues using a Labram HR 800 RS. Then, principal component analysis (PCA) support vector machine (SVM) applied for prediction. A leave-one-out cross-validation is used to train test SVM.There 50 qualified patients, including 33 androgen-dependent (ADPC) 17 CRPC. The spectral changes at...

Bladder cancer is the most common malignancy of urinary tract for which accurate measurement minimal residual disease critical to treatment and determining prognosis. Although cystoscope examination voided urine cytology remain current standard care detecting disease, these approaches are limited by mechanical trauma lack sensitivity. To develop a new noninvasive method, we developed novel contrast agent where surface superparamagnetic iron oxide (SPIO) nanoparticles functionalized with...

Abstract Androgen receptor (AR) signaling may promote renal cell carcinoma (RCC) progression via altered HIF-2α/VEGF signaling. However, it remains unclear whether AR also promotes RCC by recruiting vascular endothelial cells (ECs), key players in the development of blood vessels. In our study, increased EC proliferation and recruitment to tumor microenvironment promoted progression. Mechanistically, modulated cytokine CXCL5 expression altering AKT → NF-κB signaling, interruption using...

Hypoxia is a characteristic feature of solid tumors, leading to malignant behavior. During this process, HIF family members (HIFs) and the NF-κB pathway are activated. In addition, hypoxia-associated factor (HAF) reported participate in regulation HIFs. However, precise relationship among HIFs, HAF bladder cancer (BC) remains unknown. current investigation, T24 BC cells were exposed hypoxia, or by plasmid transfection overexpress RelA (P65) demonstrate their roles. The results indicate that...

// Tingting Zhang 1, * , Kaijie Wu Chen Ding 2, Kangwei Sun 1 Zhenfeng Guan Xinyang Wang Jer-Tsong Hsieh 3 Dalin He Jinhai Fan Department of Urology, The First Affiliated Hospital Xi’an Jiaotong University, Xi’an, Shaanxi Province, China 2 Xiangyang Central Hospital, Hubei University Arts and Science, Xiangyang, Texas Southwestern Medical Center, Dallas, TX, USA These authors have contributed equally to this work Correspondence to: Fan, e-mail: jinhaif029@126.com Keywords:...

Abstract Background Bladder Cancer (BCa) is a severe genitourinary tract disease with an uncertain pathology. Increasing evidence indicates that the tumor microenvironment plays decisive role respect to cancer progression, and this driven by cell interactions stromal components. Tenascin-C (TN-C) important extracellular matrix (ECM) component, which has been reported be involved in other types of cancer, such as breast cancer. The expression TN-C BCa tissue positively associated pathological...

TiO2 is a promising anode material for lithium-ion batteries (LIBs) due to its low cost, suitable operating voltage, and excellent structural stability. The inherent poor electron conductivity ion diffusion coefficient, however, severely limit application in lithium storage. Here, Co-doped synthesized by hydrothermal method as an since Co@TiO2 possesses large specific surface area high electronic conductivity. Thanks the Co dopants, transport are both greatly improved, which very beneficial...

Because bladder cancer (BCa) is the 9th most common malignant tumor and 13th leading cause of death due to cancer, therapeutic approaches have attracted a great deal attention from both clinicians BCa patients. Although development surgery targeted drugs has brought new challenges for traditional concept therapy, various types chemotherapy remain final treatment method many However, chemoresistance inevitably appears, failure chemotherapy. Silibinin, polyphenolic flavonoid component isolated...

Urine biomarkers offer a non‑invasive method of detecting bladder cancer, monitoring disease progression and predicting recurrence therapeutic treatment efficacy. Tenascin‑C (TN‑C), as component the extracellular matrix, is vital in cancer. However, there little to report with regard urine TN‑C its correlation cancer grade, stage, prognosis. In present study, 66 samples voided from patients 42 volunteers were obtained. The concentration was determined using an ELISA assay. between tumor...

Males have a higher incidence of renal cell carcinoma (RCC) than females, but the reason for this gender difference is unknown. Addressing question, we report discovery an androgen receptor (AR)- induced HIF2a/VEGF signal that drives RCC progression. AR attenuation or augmentation in cells altered their proliferation, migration, and invasion multiple models vitro vivo. Mechanistic investigations revealed targeting inhibited migration by modulating HIF2a/ VEGF signals at level mRNA protein...

Abstract Background : The main issue arising from bladder cancer (BCa) is the high relapse ratio and tumor progression, mechanism of which remains to be elucidated. Interaction cells with stroma microenvironment promoting progression warrants much attention researchers. Among all stromal cells, endothelial (ECs) are exceptional. Numerous studies have investigated its role angiogenesis, but not studied immunocyte recruitment chemokine secretion, important significance in has been proven....