A5100656087- MicroRNA in disease regulation
- RNA modifications and cancer
- Cancer, Lipids, and Metabolism
- Mesenchymal stem cell research
- Pancreatitis Pathology and Treatment
- Angiogenesis and VEGF in Cancer
- Cancer-related molecular mechanisms research
- Adipose Tissue and Metabolism
- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- Bladder and Urothelial Cancer Treatments
- Venous Thromboembolism Diagnosis and Management
- Extracellular vesicles in disease
- Lipid metabolism and biosynthesis
- Osteoarthritis Treatment and Mechanisms
- Renal cell carcinoma treatment
- Ferroptosis and cancer prognosis
- Circular RNAs in diseases
- Corneal Surgery and Treatments
- Diabetic Foot Ulcer Assessment and Management
- Cellular transport and secretion
- Inflammatory Biomarkers in Disease Prognosis
- Microtubule and mitosis dynamics
- Nigella sativa pharmacological applications
- Chemokine receptors and signaling
First Affiliated Hospital of Xi'an Jiaotong University
2016-2025
Xi'an Jiaotong University
2021-2025
Hospital of Hebei Province
2022-2025
Shanghai Jiao Tong University
2020-2025
Ruijin Hospital
2014-2025
Shenyang Pharmaceutical University
2024
Tongren Hospital
2020-2024
Tianjin University of Science and Technology
2023
Wuhan University of Technology
2022
Hunan Provincial People's Hospital
2017-2022
Epithelial mesenchymal transformation plays a crucial role in the metastasis of bladder cancer, which makes cancer difficult to cure. Bladder is most common malignancy urinary system, and distant leading cause death. Therefore, finding bioactive drug that can specifically inhibit epithelial may be new direction for treatment future. Thymoquinone (TQ), major active compound isolated from black seed oil (Nigella sativa), has been reported exhibit anti-inflammatory anticancer abilities. TQ its...
Thymoquinone (TQ), the major active compound isolated from black seed oil (Nigella sativa), has been reported to exhibit anti-inflammatory and anticancer abilities. However, exact molecular mechanism underlying effect of TQ is still poorly understood, especially in regard TQ's on endoplasmic reticulum stress-mediated apoptosis.The cytotoxicity T24 253J bladder cancer cells was analyzed by MTT assay, colony formation assay Annexin V-FITC/PI staining, while SV-HUC-1, SV-40 immortalized human...
The purpose of this study is to investigate the impact mesenchymal stem cell (MSC)-derived soluble factors on function keratocytes, with a particular focus processes involved in wound healing, including keratocyte activation, migration and proliferation as well extracellular matrix (ECM) synthesis.Primary cultured rabbit keratocytes were treated MSC-conditioned medium (MSC-CM). paracrine released by bone marrow MSCs examined ELISA. Time-lapse microscope was used examine closure vitro. Mouse...
Objectives The circulating neutrophil-lymphocyte ratio (NLR) has been shown to be a prognostic factor for variety of tumors. In this study, we evaluated the significance NLR in large cohort Chinese patients with pancreatic ductal adenocarcinomas (PDACs). Methods A total 381 PDAC who underwent potentially curative surgery were recruited from 2 centers Shanghai, China, between January 2004 and September 2011. Analysis overall survival (OS) was performed using Kaplan-Meier log-rank tests Cox...
Adipocytes might arise from vascular stromal cells, pericytes and endothelia within adipose tissue or bone marrow cells resident in nonadipose tissue. Here, we identified precursor fascia, an uninterrupted sheet of connective that extends throughout the body. The fragments superficial fascia rat hindlimb were highly capable spontaneous induced adipogenic differentiation but not myogenic osteogenic differentiation. Fascial preadipocytes expressed multiple markers progenitors, similar to...
Although important progress has been made in elucidating the role of tumor microenvironment development bladder cancer, little is currently known regarding interactions with vascular endothelial cells (ECs) that promote cancer progression. In present study, it reported epidermal growth factor receptor ligands induced by upregulation (VEGF)‑A and VEGF‑C via VEGF (R)2/nuclear factor‑κB signaling pathway ECs, may trigger EGFR Furthermore, interaction between ECs enhanced EC recruitment though...
In deep foundation pit engineering, the soil undergoes a complex stress path, encompassing both loading and unloading phases. The Shanghai model, an advanced constitutive effectively accounts for soil’s deformation characteristics under these varied paths, which is essential accurately predicting horizontal displacement surface settlement of pit’s enclosure structure. This model comprises eight material parameters, three initial state one small-strain parameter. Despite its sophistication,...
Myelin-oligodendrocyte glycoprotein antibody associated disease (MOGAD) is a common inflammatory of the central nervous system (CNS) in children that can lead to demyelination. Evaluation and monitoring biomarkers with its pathogenesis would provide vital information on progression therapeutic assessment. We assessed NLRP3, HMGB1, IL-6, IL-33 levels cerebrospinal fluid (CSF) pediatric patients MOGAD at different time points their association risk disease. recruited 30 (20 acute phase 10...
Abstract Background Chronic limb-threatening ischemia (CLTI) is the most severe form of peripheral arterial disease (PAD). Mesenchymal stem cell (MSC) transplantation holds promise as a treatment for CLTI; however, harsh local environment poses challenges to its effectiveness. Apoptotic vesicles (ApoVs) are extracellular produced by cells undergoing apoptosis, and they can carry various biomolecules from their parent cells, including proteins, RNA, DNA, lipids, ions, gas neurotransmitters....
Bladder cancer is the most common malignancy of urinary tract for which accurate measurement minimal residual disease critical to treatment and determining prognosis. Although cystoscope examination voided urine cytology remain current standard care detecting disease, these approaches are limited by mechanical trauma lack sensitivity. To develop a new noninvasive method, we developed novel contrast agent where surface superparamagnetic iron oxide (SPIO) nanoparticles functionalized with...
Perilipin-1 (Plin1), exclusively located on the surface of lipid droplets in adipocytes, regulates storage and hydrolysis adipose triglycerides. Plin1 deficiency primarily causes low adiposity aberrant lipolysis rodents humans. Here, we investigated whether tissue dysfunction perilipin-1 null (Plin1−/−) mice has maladaptive consequences for heart an association with hypertrophic cardiomyopathy. was expressed specifically adipocytes but undetectable cardiomyocytes. Plin1−/− were...
Lung is one of the most common sites for bladder cancer to metastasize. Although involvement epithelial-to-mesenchymal transition (EMT) in progression has been established, mechanism EMT induction remains unclear. In order investigate this, T24‑parental (P) and T24‑lung (L) cells were obtained from primary tumors lung metastatic an animal model with orthotopic spontaneous cancer, according a protocol previously described. Compared T24‑P cells, mesenchymal‑like T24‑L exhibited increased...
Abstract Background Adipose-derived mesenchymal stem cells (ADSC)-based therapy is an outstanding treatment strategy for ischaemic disease. However, the therapeutic efficacy of this not ideal due to poor paracrine function and low survival rate ADSCs in target regions. Platelet extracellular vesicles (PEVs) are nanoparticles derived from activated platelets that can participate communication between cells. Accumulating evidence indicates PEVs regulate biological functions several cell lines....
Patients with critical limb ischemia (CLI) are at great risk of major amputation and cardiovascular events. Adipose-derived mesenchymal stem cell (ADSC) therapy is a promising therapeutic strategy for CLI, but the poor engraftment insufficient angiogenic ability ADSCs limit their regenerative potential. Herein, we explored potential human umbilical vein endothelial cells (HUVECs)-derived small extracellular vesicles (sEVs) enhancing efficacy in CLI.sEVs derived from hypoxic HUVECs enhanced...
As a novel cell-permeable peptide, polyarginine (R11) showed great potential as contrast agent to target bladder cancer (BCa) for therapeutic applications. However, its diagnostic ability and uptake efficiency between BCa normal tissues is unknown. In this study, we investigated the feasibility of R11 conjugated with fluorescein isothiocyanate (FITC-R11) detecting in clinical practice.FITC-R11 was synthesized incubated cell lines (T24, 5637, RT4), immortalized human epithelial line (SVHUC)...
To determine the risk for pulmonary embolism (PE) and explore relationship between site of thrombosis PE in patients with acute lower extremity deep vein (DVT).A total 1585 hospitalized first diagnosed DVT were investigated retrospectively. The divided into two groups: non-PE group (Group 1) 2). Then, Group 2 was subgroups: asymptomatic (asPE, 2a) symptomatic (sPE, 2b). Kaplan-Meier curves logistic regression analysis used to relevant factors PE.Among patients, 458 suffered from PE,...