A5100394162- Plant Pathogens and Fungal Diseases
- Cellular Mechanics and Interactions
- Plant-Microbe Interactions and Immunity
- Microtubule and mitosis dynamics
- Hippo pathway signaling and YAP/TAZ
- Plant Physiology and Cultivation Studies
- Mycotoxins in Agriculture and Food
- 3D Printing in Biomedical Research
- Epigenetics and DNA Methylation
- Horticultural and Viticultural Research
- Viral Infectious Diseases and Gene Expression in Insects
- Aldose Reductase and Taurine
- Ubiquitin and proteasome pathways
- Microfluidic and Bio-sensing Technologies
- Genetic Mapping and Diversity in Plants and Animals
- Angiogenesis and VEGF in Cancer
- Plant tissue culture and regeneration
- Plant Virus Research Studies
- Endoplasmic Reticulum Stress and Disease
- Ferroptosis and cancer prognosis
- Plant Pathogens and Resistance
- Plant Disease Resistance and Genetics
- RNA modifications and cancer
- Fungal Biology and Applications
- Mycorrhizal Fungi and Plant Interactions
Chengdu University of Traditional Chinese Medicine
2024-2025
Guangdong Pharmaceutical University
2025
First Affiliated Hospital of Guangdong Pharmaceutical University
2025
Xi'an Jiaotong University
2023-2024
State Forestry and Grassland Administration
2022
Southern Medical University
2022
Nanfang Hospital
2022
Lanzhou University
2021
State Key Laboratory of Herbage Improvement and Grassland Agro-ecosystems
2021
Institute of Grassland Research
2021
Formins are a conserved class of proteins expressed in all eukaryotes, with known roles generating cellular actin-based structures. The mammalian formin, FRLalpha, is enriched hematopoietic cells and tissues, but its biochemical properties have not been characterized. We show that construct composed the C-terminal half FRLalpha (FRLalpha-C) dimer has multiple effects on muscle actin, including tight binding to actin filament sides, partial inhibition barbed end elongation, by capping...
The mammalian formin, mDia1, is an actin nucleation factor. Experiments in cells and vitro show that the N-terminal region potently inhibits by formin homology 2 (FH2) domain-containing C terminus RhoA binding to N partially relieves this inhibition. Cellular experiments suggest potent inhibition depends upon presence of diaphanous auto-regulatory domain (DAD) C-terminal FH2. In study, we examine detail regions required for relief. Limited proteolysis construct from residues 1-548 identifies...
Abstract Retromer is a membrane coat complex that recruited to endosomes by the small GTPase Rab7 and sorting nexin 3. The timing of this interaction consequent endosomal dynamics are thought be regulated guanine nucleotide cycle Rab7. Here we demonstrate TBC1d5, GTPase-activating protein (GAP) for Rab7, high-affinity ligand retromer cargo selective VPS26/VPS29/VPS35. crystal structure TBC1d5 GAP domain bound VPS29 complementary biochemical cellular data show loop from binds conserved...
Parkin, an E3 ubiquitin ligase well known for its role in the pathogenesis of juvenile Parkinson disease, has been considered as a candidate tumor suppressor certain types cancer. It remains unknown whether parkin is involved development pancreatic cancer, fourth leading cause cancer-related deaths worldwide. Herein, we demonstrate downregulation and copy number loss gene human cancer specimens. The expression negatively correlates with clinicopathological parameters indicating malignancy In...
ABSTRACT Micro-aspiration of oral microorganisms results in considerable enrichment within the lower respiratory tract (LRT), constituting an early event lung cancer pathogenesis. To explore correlation between malignant risk pulmonary nodules (PNs) and commensals LRT, saliva bronchial alveolar lavage fluid samples from 22 low-risk PN patients, 17 intermediate-risk 11 high-risk patients were analyzed using 16S rRNA gene sequencing. Alpha beta diversity analyses reveal minimal variation...
Radiographically, ground-glass nodules (GGN) and part-solid (PSN) in lung adenocarcinoma (LUAD) have significant heterogeneity their clinical manifestations, biological characteristics, prognosis. This study aimed to explore the of LUAD different radiological phenotypes associated factors influencing tumor evolution. We performed single-cell RNA sequencing (scRNA-seq) on tissues from eight seven cases GGN– PSN–LUAD, respectively, at disease stages, including minimally invasive (MIA), (IAC),...
Salinomycin is a monocarboxylic polyether antibiotic and potential chemotherapy drug. Our previous studies showed that salinomycin inhibited cell growth targeted CSCs in prostate cancer. However, the precise target of action unclear. In this work, we analyzed identified differentially expressed genes (DEGs) after treatment with or without using gene expression microarray vitro (PC-3 cells) vivo (NOD/SCID mice xenograft model generated from implanted PC-3 cells). Western blotting...
摘要:
Abstract Litchi downy blight, a destructive litchi disease caused by Peronophythora litchii , is controlled intensive fungicide applying. Sources of resistance are used in conventional breeding approaches, but the mechanism not well understood. Follow-up six years investigation, ‘Guiwei’ and ‘Heiye’ displayed stable susceptible resistant against to P . respectively. After 72 hour inoculation, showed few spots, while appeared brown covered with white sporangia. Germination sporangia growth...
BackgroundARF family proteins are a kind of small GTPases, which involved in regulating variety basic functions cells. In recent years, the role and molecular regulatory mechanisms ARFs tumor progression have received increasing attention, research reports on most their members increasing. However, clinical pathological relevance ARF5 cancer, especially hepatocellular carcinoma, still needs to be improved.MethodsRNA-seq data Cancer Genome Atlas (TCGA) genome tissue expression (GTEx)...
This study describes the development process of a healthy nutritional product containing black wheat granules (BWGP), which was based on Xinjiang characteristics miscellaneous grains and nuts. BWGP designed developed as local characteristic nutritious food, is produced from wheat, sesame seeds, flour, corn chickpeas, walnuts, peanuts, melon red dates, brown sugar. The then underwent sterilization followed by inflated or vacuum quantitative packing an instant ready-to-eat food. best formula...
Aim: Peritoneal dialysis is a common renal replacement method for end-stage disease. Long-term peritoneal leads to dialysis-related fibrosis, which cessation of treatment. Calpain protein belonging calcium-dependent endopeptidase family and plays an important role in extracellular matrix remodeling. Here, we evaluated the effect calpain fibrosis. Methods: We established two animal models fibrosis inhibited activity Calpain, then collected tissue evaluate progress changes β-catenin. obtained...