A5089721151- Corneal Surgery and Treatments
- Ocular Surface and Contact Lens
- Signaling Pathways in Disease
- Connexins and lens biology
- Intraocular Surgery and Lenses
- Heat shock proteins research
- Corrosion Behavior and Inhibition
- Inflammasome and immune disorders
- Advanced Glycation End Products research
- Proteoglycans and glycosaminoglycans research
- Analytical chemistry methods development
- Ocular Diseases and Behçet’s Syndrome
- interferon and immune responses
- Concrete Corrosion and Durability
- Enhanced Oil Recovery Techniques
- Silk-based biomaterials and applications
- melanin and skin pigmentation
- Immune Response and Inflammation
- Toxin Mechanisms and Immunotoxins
- Retinopathy of Prematurity Studies
- Reproductive System and Pregnancy
- Economic Development and Regional Competitiveness
- Garlic and Onion Studies
- Cancer, Lipids, and Metabolism
- Microfluidic and Capillary Electrophoresis Applications
Guangzhou University of Chinese Medicine
2021-2025
Tianjin Medical University
2015-2024
Tianjin Medical University Eye Hospital
2015-2024
Yantai University
2022-2024
Nankai University
2009-2023
Karamay Central Hospital of Xinjiang
2022-2023
Tsinghua University
2019
University Town of Shenzhen
2019
Zhengzhou Normal University
2018
Abstract Inflammation is a key factor in the pathogenesis of dry eye disease (DED). We aimed to investigate role microRNA-146a (miR-146a) regulating corneal inflammation mouse model benzalkonium chloride (BAC)-induced and TNF-α-induced NF-κB signaling pathway human epithelial cells (HCECs). A was established by administering with BAC BALB/c mice, expression TNF-α, IL-1β, IL-6, IL-8, cyclooxygenase 2 (COX2), interleukin-1 receptor-associated kinase 1 (IRAK1) TNF 6 (TRAF6) corneas mice...
Purpose: Corneal injury (CI) resulting in corneal opacity remains a clinical challenge. Exosomes (Exos) derived from bone marrow mesenchymal stem cells (BMSCs) have been proven effective repairing various tissue injuries and are also considered excellent drug carriers due to their biological properties. Recently, microRNA-29b (miR-29b) was found play an important role the autophagy regulation which correlates with cell inflammation fibrosis. However, effects of miR-29b on CI remain unclear....
The purpose of this study is to investigate the impact mesenchymal stem cell (MSC)-derived soluble factors on function keratocytes, with a particular focus processes involved in wound healing, including keratocyte activation, migration and proliferation as well extracellular matrix (ECM) synthesis.Primary cultured rabbit keratocytes were treated MSC-conditioned medium (MSC-CM). paracrine released by bone marrow MSCs examined ELISA. Time-lapse microscope was used examine closure vitro. Mouse...
Endometrium plays a key role in embryo implantation and maintenance of pregnancy. However, to repair endometrial injury is still challenge. In recent years, hydrogel materials have been widely used as effective support matrices prevent intrauterine adhesions after injury. They can also be preparation scaffolds for encapsulating MSCs certain therapeutic drugs. This study aimed develop scaffold with high tissue affinity, viscoelasticity controlled release The utilized heparin poloxamer (HP)...
Tissue engineering (TE) cornea is one of the most potential alternatives to shortage corneal donors in transplantation. Sodium alginate (SA) hydrogel commonly used as scaffold TE. Herein, we present an approach construct a composite hydrogel, which with SA fiber skeleton structure for shape retention and gelatin surface modification water retention. The light transmittance, rate, swelling rate hydrogels were characterized, tensile mechanical properties also investigated. Keratinocytes...
Pulmonary arterial smooth muscle cell (PASMC) proliferation in response to hypoxia plays an important role the vascular remodelling that occurs hypoxic pulmonary hypertension. MicroRNAs (miRs) are emerging as regulators progression of In this study, we investigated whether expression miR-17-5p is modulated by and involved hypoxia-induced PASMCs.Human PASMCs were cultured under conditions. was determined real-time RT-PCR. A BrdU incorporation assay time-lapse recording utilized determine...
Purpose: The ocular surface is considered an important route for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission. expression level of the SARS‐CoV‐2 receptor angiotensin‐converting enzyme (ACE2) vital viral infection. However, regulation ACE2 on still unknown. We aimed to determine change in inflamed corneal epithelium and explore potential drugs reduce surface. Methods: SARS-CoV-2 receptors TMPRSS2 human epithelial cells (HCECs) was examined by qPCR Western...
Human nuclear cyclophilin 33 (hCyP33) was the first protein which found to contain an RNA‐binding motif and a PPIase domain. It not known what cellular physiological roles are played by activity as well of hCyP33. In this paper, we investigated binding specificity hCyP33 different RNA using ion‐exchange chromatography affinity adsorption. Furthermore, influence RNAs protease‐coupled method. The results show that binds specifically mRNA, namely poly(A) + RNA, stimulates
Abstract The ocular albinism type I (OA1) is clinically characterized by impaired visual acuity, nystagmus, iris hypopigmentation with translucency, albinotic fundus and macular hypoplasia together normally pigmented skin hair. However, it easily misdiagnosed as congenital idiopathic nystagmus in some Chinese patients OA1 caused the G-protein coupled receptor 143 ( GPR143 ) gene mutations. Mutations FERM domain–containing 7 FRMD7 are responsible for X-linked nystagmus. In this study, five...
This study aimed to explore the effects of elevated KDM4D expression and potential therapeutic Lycium barbarum polysaccharide (LBP) on pterygium.
Purpose: Thymic stromal lymphopoietin (TSLP) is a pro-allergic cytokine that initiates allergic inflammatory reaction between epithelial and dendritic cells (DCs). miR-19b was reported to suppress TSLP expression. The present study aimed examine expression, regulation, function in conjunctivitis (AC). Methods: A murine model of experimental AC induced BALB/c mice by short ragweed pollen. serum, eye balls, conjunctiva, cervical lymph nodes (CLN) were used for the study. Gene expression...
Abstract In diabetes‐induced complications, inflammatory‐mediated endothelial dysfunction is the core of disease progression. Evidence shows that kakonein, an isoflavone common in Pueraria , can effectively treat diabetes and its complications. Therefore, we explored whether kakonein protects cardiovascular function by inhibiting inflammatory responses. this study, C57BL/6J mice were injected with streptozocin to establish a model treated or metformin for 7 days. The protective effect on...
Corneal neovascularization (CNV) is a sight-threatening condition usually associated with various inflammatory settings including chemical injury. High mobility group box 1 (HMGB1) identified as an alarmin in diverse tissue damage. Here, we evaluate the expression of HMGB1 and consequences its inhibition through selective inhibitor glycyrrhizin (GLY) alkali burn-induced corneal inflammation neovascularization. GLY effectively attenuated at both mRNA protein levels. Furthermore, slit-lamp...
Abstract In hyperglycemia-induced complications, macrophages play important roles in disease progression, and altered digestion is a key feature that dictates macrophage function. Recent evidence indicates kakonein (Ka) possesses anti-inflammatory activities for complication. this study, we established mouse model of Nlrp3+/+ Nlrp3−/− hyperglycemia administering Ka, primary culture were tested by engulfing digesting microbes. The role the cathepsin B–NLRP3 pathway involved mechanism Ka...
Purpose: To identify the molecular background of eyelid sebaceous gland carcinomas (SCs), we conducted integrated whole-exome sequencing and transcriptome for SCs in this study. Methods: The genetic alterations were studied by sequencing, messenger RNA expression was using Oxford Nanopore Technologies (ONT) five paired fresh SC tissues adjacent normal tissues. Integrated analysis exome transcriptomic information filtering candidate driver genes. Protein–protein interaction (PPI) network...