A5014156884- Venous Thromboembolism Diagnosis and Management
- Vascular Procedures and Complications
- Esophageal Cancer Research and Treatment
- Angiogenesis and VEGF in Cancer
- Cancer, Hypoxia, and Metabolism
- Gastric Cancer Management and Outcomes
- Lung Cancer Treatments and Mutations
- Peripheral Artery Disease Management
- Radiomics and Machine Learning in Medical Imaging
- Mesenchymal stem cell research
- Glycosylation and Glycoproteins Research
- Sarcoma Diagnosis and Treatment
- Diagnosis and Treatment of Venous Diseases
- Aortic aneurysm repair treatments
- Extracellular vesicles in disease
- Metabolism, Diabetes, and Cancer
- Colorectal Cancer Treatments and Studies
- Medical Imaging and Pathology Studies
- Gastrointestinal Tumor Research and Treatment
- Gastroesophageal reflux and treatments
- Osteoarthritis Treatment and Mechanisms
- Lung Cancer Diagnosis and Treatment
- Esophageal and GI Pathology
- Circular RNAs in diseases
- Diabetic Foot Ulcer Assessment and Management
First Affiliated Hospital of Xi'an Jiaotong University
2015-2025
Xi'an Jiaotong University
2005-2025
Jiangsu University
2024
Shanghai Chest Hospital
2023
Shanghai Jiao Tong University
2023
University of Leicester
2023
First Affiliated Hospital of Gannan Medical University
2021
First Affiliated Hospital of Jinan University
2021
Sun Yat-sen University
2009-2020
Sun Yat-sen University Cancer Center
2020
A fluorescently labeled peptide enables first-in-human targeted endoscopic imaging of esophageal neoplasia.
Vascular maturity and functionality are closely associated with tumor progression chemosensitivity. The antidiabetic agent metformin has shown its ability to inhibit angiogenesis in metastatic breast cancer models. However, it remains unclear if or how remodels the abnormal vasculature of cancer, while inhibiting angiogenesis.Metastatic models were constructed compare microvessel density (MVD), vascular function, lung metastasis chemosensitivity metformin-treated untreated mice. Protein...
Beneficial effects of metformin on cancer risk and mortality have been proved by epidemiological clinical studies, thus attracting research interest in elucidating the underlying mechanisms. Recently, tumour-associated macrophages (TAMs) appeared to be implicated metformin-induced antitumour activities. However, how inhibits TAMs-induced tumour progression remains ill-defined. Here, we report that anti-angiogenic activities were not or only partially contributed its direct inhibition...
Serum amyloid A (SAA), one of the major acute-phase proteins, increases several hundredfold in concentration plasma following acute inflammation, primarily as a result 200-fold increase its transcriptional rate. Functional analysis rat SAA1 promoter has identified 65-bp cytokine response unit (CRU; positions -135 to -71) that could confer responsiveness on heterologous promoter. Within this CRU, two cis-regulatory elements, corresponding NF-kappa B- and C/EBP-binding sites, were found be...
<b>Background and study aims:</b> To demonstrate the clinical use of a multimodal endoscope with targeted fluorescently labeled peptide for quantitative detection Barrett's neoplasia. <b>Patients methods:</b> We studied 50 patients esophagus using prototype peptide. Co-registered fluorescence reflectance images were converted to ratios correct differences in distance geometry over image field view. The ratio segmented unique threshold that maximized variance between high low intensities...
Substantial data from preclinical studies have revealed the biphasic effects of statins on cardiovascular angiogenesis. Although some reported anti‐angiogenic potential in malignant tumors, underlying mechanism remains poorly understood. The aim this study is to elucidate by which simvastatin, a member statin family, inhibits tumor Simvastatin significantly suppressed cell‐conditioned medium‐induced angiogenic promotion vitro, and resulted dose‐dependent anti‐angiogenesis vivo. Further...
MicroRNAs (miRNAs) are important regulators of pathobiological processes in various cancer. In the present study, we demonstrated that miR-93 expression was significantly up-regulated gastric cancer tissues compared with matched normal mucosal tissues. High associated lymph node metastasis and tumor-node-metastasis (TNM) stage. Functionally, ectopic promoted cell proliferation, migration, invasion, EMT phenotypes, repressed apoptosis G1 cycle arrest vitro, tumor formation vivo. We further...
Triple negative breast cancer (TNBC) is an invasive and metastatic phenotype of with limited treatment options. Published studies have demonstrated inhibitory effect HIF-α inhibition by its inhibitor YC-1 (lificiguat) on growth angiogenesis TNBC. However, the underlying mechanism remains poorly understood. In current paper, our results show that HIF-1α significantly inhibited TNBC increasing cellular apoptosis decreasing MVD, independent a cell-autonomous in both endothelial tumor cells....
Breast cancer is a common but deadly disease among women. Medical imaging an effective method to diagnose breast cancer, manual image screening time-consuming. In this study, novel computer-aided diagnosis system for detection called BCDNet proposed. We leverage pre-trained convolutional neural networks (CNNs) representation learning and propose adaptive backbone selection algorithm obtain the best CNN model. An extreme machine serves as classifier in BCDNet, bat with chaotic maps put...
Abstract Background Chronic limb-threatening ischemia (CLTI) is the most severe form of peripheral arterial disease (PAD). Mesenchymal stem cell (MSC) transplantation holds promise as a treatment for CLTI; however, harsh local environment poses challenges to its effectiveness. Apoptotic vesicles (ApoVs) are extracellular produced by cells undergoing apoptosis, and they can carry various biomolecules from their parent cells, including proteins, RNA, DNA, lipids, ions, gas neurotransmitters....
// Ji-Chang Wang 1, 2, * , Guang-Yue Li 3, Ping-Ping 2 Xin Sun 4 Wei-Ming 1 Yan Shao-Ying Lu and Pei-Jun Liu Department of Vascular Surgery, First Affiliated Hospital Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710061, P.R.China Center for Translational Medicine, 3 Science Technology, Thoracic Surgery Oncology, These two authors contributed equally to this work share co-first Correspondence to: Liu, email: liupeijun@mail.xjtu.edu.cn Lu, robertlu@mail.xjtu.edu.cn Keywords: metformin,...
Abstract Background Adipose-derived mesenchymal stem cells (ADSC)-based therapy is an outstanding treatment strategy for ischaemic disease. However, the therapeutic efficacy of this not ideal due to poor paracrine function and low survival rate ADSCs in target regions. Platelet extracellular vesicles (PEVs) are nanoparticles derived from activated platelets that can participate communication between cells. Accumulating evidence indicates PEVs regulate biological functions several cell lines....
Patients with critical limb ischemia (CLI) are at great risk of major amputation and cardiovascular events. Adipose-derived mesenchymal stem cell (ADSC) therapy is a promising therapeutic strategy for CLI, but the poor engraftment insufficient angiogenic ability ADSCs limit their regenerative potential. Herein, we explored potential human umbilical vein endothelial cells (HUVECs)-derived small extracellular vesicles (sEVs) enhancing efficacy in CLI.sEVs derived from hypoxic HUVECs enhanced...
The development of chemoresistance which results in a poor prognosis often renders current treatments for colorectal cancer (CRC). In this study, we identified reduced microvessel density (MVD) and vascular immaturity resulting from endothelial apoptosis as therapeutic targets overcoming chemoresistance. We focused on the effect metformin MVD, maturity, CRCs with non-angiogenic phenotype, further investigated its situ transplanted models were established to compare function tumors metformin-...
Objectives: To identify the role and mechanism of a male specific gene, SRY, in I/R-induced hepatic injury. Background: Males are more vulnerable to I/R injury than females. However, these sex-based differences remains poorly defined. Methods: Clinicopathologic data patients who underwent resection were identified from an international multi-institutional database. Liver SRY TG mice generated, subjected insult with their littermate WT controls vivo. In vitro experiments performed by treating...
This study aims to explore the predictive value of T2-weighted imaging (T2WI), apparent diffusion coefficient (ADC), and early-delayed phases enhanced magnetic resonance (DCE-MRI) radiomics prediction model in determining human epidermal growth factor receptor 2 status breast cancer.
Endoscopy can be used to monitor the onset of metaplastic transformation and observe progression neoplasia in small animal models Barrett's esophagus. By avoiding sacrifice, natural history this disease studied a longitudinal fashion. We aim characterize endoscopic features esophageal mucosa at various stages metaplasia-dysplasia-carcinoma sequence rat reflux model for comparison with histology. Acid bile was produced by introducing side-to-side esophago-gastro-jejunostomy Sprague-Dawley...
To determine the risk for pulmonary embolism (PE) and explore relationship between site of thrombosis PE in patients with acute lower extremity deep vein (DVT).A total 1585 hospitalized first diagnosed DVT were investigated retrospectively. The divided into two groups: non-PE group (Group 1) 2). Then, Group 2 was subgroups: asymptomatic (asPE, 2a) symptomatic (sPE, 2b). Kaplan-Meier curves logistic regression analysis used to relevant factors PE.Among patients, 458 suffered from PE,...
// Weiming Li 1, * , Huan Jia 2, Jichang Wang 1 Hao Guan Yan Dan Zhang 3 Yanan Tang Thomas D. 4 Shaoying Lu Department of Vascular Surgery, The First Affiliated Hospital Xi’an Jiaotong University, Xi’an, Shaanxi Province, 710061, P.R.China 2 General Medical 710077, Gastroenterology, Division Internal Medicine, University Michigan, Ann Arbor, MI 48109, USA Co-first authors, These authors contributed equally to this work Correspondence to: Lu, email: robertlu@mail.xjtu.edu.cn...