A5101589731- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Cancer, Hypoxia, and Metabolism
- Acute Ischemic Stroke Management
- Diabetes Treatment and Management
- Uterine Myomas and Treatments
- Neuropeptides and Animal Physiology
- Angiogenesis and VEGF in Cancer
- Peripheral Artery Disease Management
- Peptidase Inhibition and Analysis
- Metabolism, Diabetes, and Cancer
- Coronary Interventions and Diagnostics
- Vascular Procedures and Complications
- MicroRNA in disease regulation
- Gynecological conditions and treatments
- Venous Thromboembolism Diagnosis and Management
- Lung Cancer Diagnosis and Treatment
- Central Venous Catheters and Hemodialysis
- HER2/EGFR in Cancer Research
- Endometriosis Research and Treatment
- Luminescence and Fluorescent Materials
- PI3K/AKT/mTOR signaling in cancer
- Cancer, Lipids, and Metabolism
- Radiomics and Machine Learning in Medical Imaging
- Drug Transport and Resistance Mechanisms
Kaiping Central Hospital
2025
First Affiliated Hospital of Xi'an Jiaotong University
2014-2024
Xi'an Jiaotong University
2009-2024
Computational Physics (United States)
2024
Guangzhou Medical University
2024
Nantong University
2024
Yangtze University
2024
Somerville Hospital
2024
Affiliated Hospital of Nantong University
2024
Fleet Science Center
2010
Vascular maturity and functionality are closely associated with tumor progression chemosensitivity. The antidiabetic agent metformin has shown its ability to inhibit angiogenesis in metastatic breast cancer models. However, it remains unclear if or how remodels the abnormal vasculature of cancer, while inhibiting angiogenesis.Metastatic models were constructed compare microvessel density (MVD), vascular function, lung metastasis chemosensitivity metformin-treated untreated mice. Protein...
Atherosclerosis constitutes the leading contributor to morbidity and mortality in cardiovascular cerebrovascular diseases. Lipid deposition inflammatory response are crucial triggers for development of atherosclerosis. Recently, microRNAs (miRNAs) have drawn more attention due their prominent function on process lipid accumulation disease. Here, we investigated involvement miR-21 lipopolysaccharide (LPS)-induced macrophages. After stimulation with indicated times doses LPS, mRNA levels were...
Beneficial effects of metformin on cancer risk and mortality have been proved by epidemiological clinical studies, thus attracting research interest in elucidating the underlying mechanisms. Recently, tumour-associated macrophages (TAMs) appeared to be implicated metformin-induced antitumour activities. However, how inhibits TAMs-induced tumour progression remains ill-defined. Here, we report that anti-angiogenic activities were not or only partially contributed its direct inhibition...
The discovery of two classes heterocyclic dipeptidyl peptidase IV (DPP-4) inhibitors, pyrimidinones and pyrimidinediones, is described. After a single oral dose, these potent, selective, noncovalent inhibitors provide sustained reduction plasma DPP-4 activity lowering blood glucose in animal models diabetes. Compounds 13a, 27b, 27j were selected for development.
In CNS drug discovery, the estimation of brain exposure to lead compounds is critical for their optimization. Compounds need cross blood–brain barrier (BBB) reach pharmacological targets in CNS. The BBB a complex system involving passive and active mechanisms transport efflux transporters such as P-glycoproteins (P-gp) breast cancer resistance protein (BCRP), which play an essential role penetration small molecules. Several vivo, vitro, silico methods are available estimate human...
Substantial data from preclinical studies have revealed the biphasic effects of statins on cardiovascular angiogenesis. Although some reported anti‐angiogenic potential in malignant tumors, underlying mechanism remains poorly understood. The aim this study is to elucidate by which simvastatin, a member statin family, inhibits tumor Simvastatin significantly suppressed cell‐conditioned medium‐induced angiogenic promotion vitro, and resulted dose‐dependent anti‐angiogenesis vivo. Further...
Triple negative breast cancer (TNBC) is an invasive and metastatic phenotype of with limited treatment options. Published studies have demonstrated inhibitory effect HIF-α inhibition by its inhibitor YC-1 (lificiguat) on growth angiogenesis TNBC. However, the underlying mechanism remains poorly understood. In current paper, our results show that HIF-1α significantly inhibited TNBC increasing cellular apoptosis decreasing MVD, independent a cell-autonomous in both endothelial tumor cells....
The American Heart Association recently released an updated algorithm for evaluating cardiovascular health (CVH), Life's Essential 8 (LE8). However, few studies have examined the association of LE8 with risk disease (CVD) and mortality among individuals chronic kidney (CKD). We investigated whether was associated subsequent CVD in Chinese population adults CKD. This prospective study included 18,716 (55.4 ± 14.0 years, 77.9 % men) CKD free at baseline from Kailuan study. A score (range 0-100...
The inhibition of receptor tyrosine kinases (RTKs) has become a successful approach in the development anticancer agents. Many potent small-molecule kinase inhibitors have been discovered. We report herein series pyrrolo-fused-heterocycle-2-indolinone analogues as vascular endothelial growth factor (VEGFR), platelet-derived (PDGFR), and c-Kit. Among them, some pyrrolo-fused six- seven-membered-heterocycle derivatives such 9, 15, 23, 25 are VEGFR, PDGFR, c-Kit both enzymatically (<50 nM)...
Burnout and working motivation are two interconnected concepts that significantly influence doctors' performance overall well-being. However, the relationship between burnout among rehabilitation doctors remain unclear. Therefore, purpose of this study was to explore association in China. A multistage sampling scheme employed select as participants. total 220 participants from 21 medical institutions 7 cities China were included final analysis. The measurement motivation, burnout, general...
Abstract Tenascin‐c is an extracellular matrix glycoprotein, the expression of which relates to progression atherosclerosis, myocardial infarction and heart failure. Annexin II acts as a cell surface receptor tenascin‐c. This study aimed delineate role tenascin‐c annexin in macrophages presented atherosclerotic plaque. Animal models with lesions were established using ApoE‐ KO mice fed high‐cholesterol diet. The was determined by qRT ‐ PCR , Western blot immunohistochemistry analysis. Raw...
<b><i>Introduction:</i></b> This study aimed to examine whether intraplaque neovascularization (IPN) of carotid plaques, as characterized by contrast-enhanced ultrasound (CEUS), is associated with ischemic stroke recurrence in patients atherosclerosis. <b><i>Methods:</i></b> We conducted a prospective consecutive recent and at least one atherosclerotic plaque the artery on side consistent symptoms. All underwent CEUS after their first...
The development of chemoresistance which results in a poor prognosis often renders current treatments for colorectal cancer (CRC). In this study, we identified reduced microvessel density (MVD) and vascular immaturity resulting from endothelial apoptosis as therapeutic targets overcoming chemoresistance. We focused on the effect metformin MVD, maturity, CRCs with non-angiogenic phenotype, further investigated its situ transplanted models were established to compare function tumors metformin-...
Objective: To ascertain the feasibility of using shear wave velocity (SWV) in assessing stiffness carotid plaque by supersonic imaging (SSI) and explore preliminary clinical value for such evaluation.Materials Methods: Supersonic was performed 142 patients with ischemic stroke, including 76 males 66 females mean age years (range, 45-80 years).The maximum, minimum, values SWV were measured 129 plaques.SWVs compared between echolucent echogenic plaques.Correlations SWVs serum homocysteine...
Placental growth factor (PlGF) related signaling pathway has been shown to have close relationship with the progression of cancers. Metformin reported an inhibitory effect on PlGF expression in a breast cancer model. However, little is known about whether anti-neoplastic activity metformin contributed by its expression. Protein, mRNA and secretion levels were tested proliferation cells was determined. After treatment metformin, BALB/c mice bearing 4T1 tumors sacrificed immunohistochemistry...
Performing activities of daily living comprise an important risk factor for falls among non-bedridden stroke inpatients in rehabilitation departments.
Autophagy is an essential process for breaking down macromolecules and aged/damaged cellular organelles to maintain energy balance nutritional status. The idea that autophagy regulates lipid metabolism emerging concept with important implications atherosclerosis. However, the potential role of its relationship in foam cell formation remains unclear. In this study, we found was involved lipopolysaccharide (LPS)-induced cells at least partially dependent on adipose differentiation-related...
Background: Neovascularization is one of the most important risk factors for unstable plaque. This study was designed to correlate plaque thickness, artery stenosis and levels serum C-reactive protein with degree intraplaque enhancement determined by contrast-enhanced ultrasound. Patients methods: Contrast-enhanced ultrasound performed on 72 carotid atherosclerotic plaques in 48 patients. Contrast within categorized as grade 1, 2 or 3. Maximum thickness measured short-axis view. Carotid...
In CNS drug discovery, estimation of brain exposure lead compounds is critical for their optimization. Compounds need to cross the blood-brain barrier (BBB) reach pharmacological targets in CNS. The BBB a complex system involving passive and active mechanisms transport efflux transporters such as P-glycoproteins (P-gp) breast cancer resistance protein (BCRP), which play an essential role penetration small molecules. Several vivo, vitro silico methods are available estimate human penetration....