A5100448697- Cerebrovascular and Carotid Artery Diseases
- Peripheral Artery Disease Management
- Shoulder Injury and Treatment
- Anesthesia and Pain Management
- Cancer-related molecular mechanisms research
- Reconstructive Surgery and Microvascular Techniques
- Nausea and vomiting management
- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Pain Management and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Orthopedic Surgery and Rehabilitation
- Helicobacter pylori-related gastroenterology studies
- RNA modifications and cancer
- Vascular Procedures and Complications
- Peripheral Nerve Disorders
- Knee injuries and reconstruction techniques
- Bone fractures and treatments
- Medical History and Innovations
- Digestive system and related health
- Silk-based biomaterials and applications
- Selenium in Biological Systems
- Diagnosis and Treatment of Venous Diseases
- Vasculitis and related conditions
- Liver physiology and pathology
Hangzhou Hospital of Traditional Chinese Medicine
2018-2025
Zhejiang Chinese Medical University
2024-2025
Beijing Jishuitan Hospital
2015-2024
Capital Medical University
2024
Peking University
2015-2024
Yangzhou University
2024
People's Hospital of Bishan District
2023-2024
Zhejiang Provincial Hospital of TCM
2023
First Affiliated Hospital of Anhui Medical University
2021-2022
Anhui Medical University
2021-2022
SummaryObjectivePrevious epidemiological and experimental studies have yielded conflicting results regarding the influence of human micronutrient levels on risk colorectal polyps (CP). In our study, we conducted a two-sample Mendelian randomization (MR) investigation to probe link between 13 micronutrients (calcium, selenium, magnesium, phosphorus, folate, vitamins B-6, B-12, C, D, beta-carotene, iron, zinc, copper) genetic susceptibility CP.MethodsSummary statistics for CP (n = 463,010)...
Cirrhosis is a leading cause of mortality in patients with chronic liver disease (CLD). The rapid development metabolomic technologies has enabled the capture metabolic changes related to progression cirrhosis. This study used proton nuclear magnetic resonance (1 H-NMR) serum metabolomics data from UK Biobank (UKB) and employed elastic net-regularized Cox proportional hazards models explore role cirrhosis risk stratification CLD. Metabolomic were integrated aspartate aminotransferase...
Gastric Leucine-rich repeat-containing G-protein-coupled receptor 5 (Lgr5) cells exert important functions during injury and homeostasis. Bone morphogenetic protein (BMP) signaling regulates gastric inflammation epithelial We investigated if BMP controls the fate of Lgr5+ve inflammation.The H+/K+-adenosine triphosphatase β-subunit promoter was used to express inhibitor noggin (Nog) in stomach (H+/K+-Nog mice). Inhibition Lgr5 achieved by crossing Lgr5-EGFP-ires-CreERT2 (Lgr5-Cre) mice with...
We reported that transgenic expression of the bone morphogenetic protein (BMP) signaling inhibitor noggin in mouse stomach, leads to parietal-cell (PC) loss, expansion transitional cells expressing markers both mucus neck and zymogenic lineages, activation proliferative mechanisms. Because these cellular changes were associated with increased levels hormone gastrin, we investigated if gastrin mediates phenotypic mice (NogTG mice). Three-month-old NogTG crossed gastrin-deficient (GasKO mice)...
The aim of this study was to investigate the relationship between weight-adjusted-waist index (WWI) and diabetic kidney disease in individuals afflicted with type 2 diabetes.
Background: The diagnosis of Precancerous Lesions Gastric Cancer (PLGC) is challenging in clinical practice. We conducted a study by analyzing the information relevant chromosome copy number variations (CNV) TCGA database followed UCAD technique to evaluate value Chromosomal Instability (CIN) assay PLGC. Methods: Based on screening gastric cancer related data database, CNV analysis was performed explore cancer. gastroscopic pathology results, 12 specimens patients with severe atrophy were...
Nalbuphine has gradually become a commonly used clinical analgesic drug for painless hysteroscopy. The aim of our study was to identify the median effective dose (ED50) propofol combined with nalbuphine hysteroscopy.Sixty-one patients aged 18-60 years were recruited undergo elective Patients administered 0.1 μg/kg (group A) or 0.2 B) intravenously 3 min before endoscopic placement. Dixon sequential method an initial intravenous 2 mg/kg, which varied by 0.5 mg per kilogram.The ED50 1.729...
The stem cell niche comprises soluble molecules and extracellular matrix components which provide chemical mechanical cues that determine the differentiation of cells. Here, effect polyelectrolyte multilayer (PEM) composition terminal layer fabricated with layer-by-layer technique (LBL) pairing either hyaluronan [in its native (nHA) oxidized form (oHA)] or chondroitin sulfate (CS) type I collagen (Col I) is investigated on chondrogenic human umbilical mesenchymal cells (hUC-MSCs). Physical...
For distal malignant biliary obstruction (MBO), a percutaneous metal stent is usually inserted by the transpapillary method. However, stent-related complications and recurrent following placement are concerns, survival analysis of patients with MBO has rarely been done.From January 2012 to March 2016, 104 underwent uncovered for at our institution. Clinical success, complications, rates, predictors were analyzed.Of total patients, clinical success after insertion was achieved in 93 (90.3%)....
<title>Abstract</title> This study aimed to evaluate the efficacy of ultrasound-guided erector spinae plane block (ESPB) in patients with hepatocellular carcinoma undergoing laparoscopic left hemihepatectomy. One hundred seventy-two were retrospectively examined and compared: 90 who received intravenous patient-controlled analgesia (PCA) ESPB 82 PCA alone. Propensity score matching was performed balance covariates between groups. Matching resulted 25 matched pairs. Visual analog scale pain...
Copper-mediated cell death presents distinct pathways from established apoptosis processes, suggesting alternative therapeutic approaches for colon cancer. Our research aims to develop a predictive framework utilizing long-noncoding RNAs (lncRNAs) related cuproptosis predict cancer outcomes while examining immune interactions and intercellular signaling. We obtained cancer-related human mRNA expression profiles clinical information the Cancer Genome Atlas repository. To isolate lncRNAs...
Background There were about 1,090,000 gastric cancer (GC) cases in 2020 China. The incidence and mortality rates ranked the fifth third among all kinds of cancers Early diagnosis plays an important role treatment prognosis cancer. In recent years, noninvasive diagnosis, especially plasma exosome lncRNAs, has become a promissing biomarkers with high specificity sensitivity for early cancers. Methods this study, exosomes patients extracted efficiently by affinity membrane separation...
The fibular osteocutaneous flap is a versatile option for range of reconstructive challenges. In this report, novel in which V-shaped strut fibula was used to reconstruct the weight-bearing function calcaneus has been described. case raised interesting questions about vascularity flap, we addressed with an anatomic study lower leg. Eight cadavers were injected modified lead oxide–gelatin mixture. Two selected three-dimensional modeling. Dissections each layer performed outline course every...
To evaluate the role of multidetector row spiral computed tomography in diagnosis popliteal artery entrapment syndrome (PAES).Ten patients (13 limbs) were diagnosed as PAES through open surgery Peking Union Medical College Hospital from January 2006 to December 2009, among whom three (30.0%) had both limbs involved.Eleven (84.6%) occlusions at admission. While only 15.4% by positional stress test, Doppler ultrasound, and arterial angiography, disease was confirmed all 10 tomography. As shown...
Objective To investigate the optimal treatment strategy of spontaneous isolated dissection superior mesenteric artery (SIDSMA) and effect anticoagulation therapy on prognosis SIDSMA. Methods The clinical data 29 patients presented with acute or subacute ischemia (a history less than 14 days) due to SIDSMA admitted Department Vascular Surgery Peking Union Medical College Hospital from January 1st 2003 December 31th 2016 were retrospectively analyzed. Results In this study,28 cases male...