A5014351599- Tissue Engineering and Regenerative Medicine
- Reconstructive Surgery and Microvascular Techniques
- Electrospun Nanofibers in Biomedical Applications
- Bone fractures and treatments
- COVID-19 Clinical Research Studies
- Reconstructive Facial Surgery Techniques
- Long-Term Effects of COVID-19
- Orthopedic Surgery and Rehabilitation
- Radiomics and Machine Learning in Medical Imaging
- Bone Tissue Engineering Materials
- Tracheal and airway disorders
- Renal and related cancers
- SARS-CoV-2 and COVID-19 Research
- Infectious Aortic and Vascular Conditions
- Breast Cancer Treatment Studies
- MRI in cancer diagnosis
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- Vascular Procedures and Complications
- 3D Printing in Biomedical Research
- Pancreatitis Pathology and Treatment
- Lung Cancer Diagnosis and Treatment
- Traditional Chinese Medicine Studies
- Anatomy and Medical Technology
- Gastric Cancer Management and Outcomes
Wenzhou Medical University
2015-2025
Ningbo University
2024
Xiangya Hospital Central South University
2023
Central South University
2023
Wuhan University of Technology
2023
Ningbo First Hospital
2020-2022
Zhejiang University
2012-2021
Wenzhou University
2010-2021
Sun Yat-sen Memorial Hospital
2019
Sun Yat-sen University
2019
Early identification of severe patients with coronavirus disease 2019 (COVID-19) is very important for individual treatment. We included 203 COVID-19 by propensity score matching in this retrospective, case-control study. The effects serum lactate dehydrogenase (LDH) at admission on were evaluated. found that LDH levels had a 58.7% sensitivity and 82.0% specificity, based best cut-off 277.00 U/L, predicting COVID-19. And 359.50 U/L the resulted 93.8% sensitivity, 88.2% specificity death...
The medial sural artery perforator flap is a reliable cutaneous that can be used for soft-tissue reconstruction in the extremities. purposes of this article are to fully document vascular basis and report its use distal extremities.Ten fresh cadavers were injected with standardized injection lead oxide three-dimensional visualization using spiral computed tomography scanner specialized software (Materialise Interactive Medical Image Control System). origin, course, distribution posterior leg...
The extracellular matrix (ECM) is a network of proteins and other molecules that encase support cells tissues in the body. As clinical biotechnological uses ECM are expanding, it essential to assess environmental impact associated with its production. Due high levels customization, various laboratories employ distinct methods; therefore, this study evaluates three common protocols. Life cycle assessment (LCA) methodology has been developed evaluate impacts products produced through diverse...
Abstract Objectives To investigate laboratory markers for COVID‐19 progression in patients with different medical conditions. Methods We performed a multicenter retrospective study of 836 cases Hubei. avoid the collinearity among indicators, principal component analysis (PCA) followed by partial least squares discriminant (PLS‐DA) was to obtain an overview assessments. Multivariable logistic regression and multivariable Cox proportional hazards were respectively used explore risk factors...
BackgroundInfection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in children is associated better outcomes than adults. The inflammatory response to COVID-19 infection remains poorly characterised.MethodsWe retrospectively analysed the medical records of 127 laboratory-confirmed patients aged 1 month 16 years from Wuhan and Jingzhou Hubei Province. Patients presented between January 25th March 24th 2020. Information on clinical features, laboratory results, plasma...
Our work provides a facile yet efficient strategy to fabricate hydrogel actuators with rewritable patterns and programmable shape deformations.
Abstract Decellularization processes may variably distort or degrade extracellular matrix (ECM) structure. In this study, two perfusion routes (PR) were tested on SD rat lung samples. One decellularization protocol, PR1, was perfused through the pulmonary artery. The other PR2, trachea. Both protocols used by same detergent‐based (sodium dodecyl sulphate and Triton X‐100) with different flow continuous perfusion. There no visible difference in vessel architecture between PR1‐...
Objective This study aimed to develop and externally validate a COVID-19 mortality risk prediction algorithm. Design Retrospective cohort study. Setting Five designated tertiary hospitals for in Hubei province, China. Participants We routinely collected medical data of 1364 confirmed adult patients with between 8 January 19 March 2020. Among them, 1088 from two Wuhan were used the prognostic model, 276 three outside external validation. All followed up maximal 60 days after diagnosis...
The skin barrier is essential to prevent pathogenic invasion. When injury occurs, multiple biological pathways are promptly activated and wound repair processes triggered. effective healing of wounds for survival, dysfunction could result from aberrant repair. Preparation many hydrogels, which involve the addition growth/cell factors or mimic extracellular matrix (ECM) components, has not resulted in significant advances tissue recovery. ECM contains a large number biologically active...
Chronic kidney disease has been recognized as a major public health problem worldwide and renal fibrosis is common pathological process occurring in chronic failure. It very promising to find the strategies slow or even prevent progression of fibrosis. This study focused on whether decellularized scaffolds potential be model cellular mechanisms tissue donors for engineering. In order evaluate feasibility derived from kidneys, histology, proteomics ELISA will used analysis changes structure...
Spinal cord decellularized (DC) scaffolds can promote axonal regeneration and restore hindlimb motor function of spinal defect rats. However, scarring caused by damage to the astrocytes at margin injury hinder axon regeneration. Olfactory ensheathing cells (OECs) integrate migrate with site injury, providing a bridge for axons penetrate scars grow into lesion cores. The purpose this study was evaluate whether DC carrying OECs could better growth. For these studies, were cocultured primary...
Abstract A series of complex influencing factors lead to failure neural regeneration after spinal cord injury (SCI). Up now, there is no robust treatment that can restore the loss function caused by injury. Because damaged axons do not spontaneously regenerate in their naturally inhibitory microenvironments, biomaterials induce appear as attractive treatments improve microenvironmental conditions SCI. In this study, we report novel use decellularized (DC) scaffolds provide contact guidance...
There is a dearth of detailed published work on the anatomy ulnar artery perforators. The objective this study was to fully document vascular basis free proximal perforator flap and report its use in reconstruction hand.(1) perforators were studied 25 fresh cadavers 10 cast preparations. Cadavers injected with lead oxide for 3-dimensional reconstruction. origin, course, distribution comprehensively documented. (2) Between August 2011 January 2013, 29 flaps utilized soft-tissue defects hand...
Nearly 50 million patients in China live with end-stage renal disease (ESRD), and only about 4000 may receive kidney transplantation. The purpose of this study was to investigate regeneration vessels post whole decellularized kidneys transplantation vivo. We donor rats by perfusing a detergent through the abdominal aorta, yielding feasible extracellular matrix, confirmed for acellularity before Based on concept using body as bioreactor, we orthotopically transplanted ureter scaffolds...
There are increasing numbers of patients underwent partial nephrectomy, and recovery disturbed renal function is imperative post nephrectomy. We previously have demonstrated the decellularized (DC) scaffolds could mediate residual kidney regeneration thus improve after However, cellular changes including angiogenesis in implanted DC scaffold has not yet been elaborated. In this study, we observed that promoted proliferation human umbilical vein endothelial cells (HUVEC) adhered to vitro....
Pulmonary fibrosis is a respiratory disease caused by the proliferation of fibroblasts and accumulation extracellular matrix (ECM). It known that lung ECM mainly composed three-dimensional fiber mesh filled with various high-molecular-weight proteins. However, small-molecular-weight proteins in their differences between normal fibrotic are largely unknown.Healthy adult male Sprague-Dawley rats (Rattus norvegicus) weighing about 150 to 200 g were randomly divided into three groups using...
The purposes of this article are to introduce and assess the results a long-term follow-up using anterograde pedicle flap based on dorsal branches proper digital neurovascular bundles from dorsum middle phalanx for fingertip defect.Between February 2011 December 2012, 31 patients underwent reconstruction defects homodigital perforator in phalanx. defect size ranged 1.3 cm × 1.5 2.4 3.0 cm. During surgery, was designed phalangeal region. bundle consisting an artery, vein, sensory nerve;...