A5102025772- COVID-19 Clinical Research Studies
- Long-Term Effects of COVID-19
- SARS-CoV-2 and COVID-19 Research
- Osteoarthritis Treatment and Mechanisms
- Aquaculture Nutrition and Growth
- Spine and Intervertebral Disc Pathology
- Cytokine Signaling Pathways and Interactions
- Glioma Diagnosis and Treatment
- Immunotherapy and Immune Responses
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Obstructive Sleep Apnea Research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Reproductive biology and impacts on aquatic species
- COVID-19 epidemiological studies
- Ferroptosis and cancer prognosis
- Cancer Mechanisms and Therapy
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Respiratory Support and Mechanisms
- Immune Cell Function and Interaction
- interferon and immune responses
- Pancreatitis Pathology and Treatment
- Cancer Cells and Metastasis
- Inflammatory mediators and NSAID effects
Zhejiang Marine Fisheries Research Institute
2023-2025
Huazhong University of Science and Technology
2013-2025
Tongji Hospital
2013-2025
Fifth Affiliated Hospital of Zhengzhou University
2022-2025
Peking University
2023-2025
Sun Yat-sen University
2021-2024
Yangtze University
2006-2024
Third Affiliated Hospital of Zhengzhou University
2024
First Affiliated Hospital of Wannan Medical College
2015-2024
Zhengzhou University
2024
Early identification of severe patients with coronavirus disease 2019 (COVID-19) is very important for individual treatment. We included 203 COVID-19 by propensity score matching in this retrospective, case-control study. The effects serum lactate dehydrogenase (LDH) at admission on were evaluated. found that LDH levels had a 58.7% sensitivity and 82.0% specificity, based best cut-off 277.00 U/L, predicting COVID-19. And 359.50 U/L the resulted 93.8% sensitivity, 88.2% specificity death...
Background Osteoarthritis (OA) is a common aging-related degenerative joint disease with chronic inflammation as its possible pathogenesis. Oroxin B (OB), flavonoid isolated from traditional Chinese herbal medicine, possesses anti-inflammation properties which may be involved in regulating the pathogenesis of OA, but mechanism has not been elucidated. Our study was first to explore potential chondroprotective effect and elucidate underlying OB OA. Methods In vitro , primary mice chondrocytes...
Abstract Background We aimed to evaluate the efficacy and safety of leflunomide, an approved dihydroorotate dehydrogenase inhibitor, treat coronavirus disease 2019 (COVID-19) patients with prolonged postsymptomatic viral shedding. Methods conducted a prospective, randomized controlled, open-label trial involving hospitalized adult COVID-19 polymerase chain reaction (PCR) positivity. Patients were randomly assigned receive either leflunomide (50 mg every 12 hours, 3 consecutive times, orally;...
Ferroptosis, as an iron-dependent form of necrotic cell death, has been reported to affect activities nucleus pulposus cells (NPCs). However, its role in the pathogenesis intervertebral disc degeneration (IDD) is largely unknown. Notably, our bioinformatics analysis predicted that circ_0072464 was downregulated IDD mice. Therefore, this study aimed at clarifying mechanisms extracellular vesicle- (EV-) encapsulated derived from bone marrow mesenchymal stem (BMSCs) NPC ferroptosis IDD. EVs...
Abstract Objective Synthesizing and evaluating inconsistent medical evidence is essential in evidence-based medicine. This study aimed to employ ChatGPT as a sophisticated scientific reasoning engine identify conflicting clinical summarize unresolved questions inform further research. Materials Methods We evaluated ChatGPT’s effectiveness identifying investigated its principles of logical reasoning. An automated framework was developed generate PubMed dataset focused on controversial topics....
Canonical Wnt signaling is critical for the control of osteoblast differentiation in human mesenchymal stem cells. MicroRNAs (miRs) are essential regulators cell by post‑transcriptional regulation target gene expression. The aim present study was to investigate molecular mechanism which miR‑142‑3p promotes osteoblastic using fetal 1.19 (hFOB1.19), real-time PCR and western blot analysis. Results showed an increased expression during precursor line, hFOB1.19. In addition, ectopic...
CD276 (also known as B7-H3) is one of the most important immune checkpoints CD28 and B7 superfamily, its abnormal expression closely associated with various types cancer. It has been shown that able to inhibit function T cells, this gene may potentially be a promising immunotherapy target for different cancer.Since few systematic studies have published on role in cancer date, present study employed single-cell sequencing bioinformatics methods analyze patterns, clinical significance,...
ABSTRACT RNF7 (Ring Finger Protein 7) is a key component of CRLs (Cullin‐RING‐type E3 ubiquitin ligases) and has been found to possess intrinsic anti‐ROS capabilities. Aberrant expression observed in various tumor types known significantly influence initiation progression. However, the specific role glioblastoma remains unclear. IDH (isocitrate dehydrogenase) mutations, which induce metabolic reprogramming result notable heterogeneity among glioma with different genotypes. Through analysis...
The inherent deficiency of phospholipids in Artemia limits its nutritional value as live prey for marine fish larvae. In our previous study, we optimized a phospholipid enrichment method by incubating nauplii with 10 g soybean lecithin per m3 seawater 12 h, significantly enhancing their content. Purpose: present study evaluated the impact this on yellow drum (Nibea albiflora) larvae, focusing growth performance, intestinal morphology, body composition, weaning success, and desiccation stress...
Background/Objectives: This study evaluated the impact of influenza vaccination on mortality using real-world data and compared effect current-season-only versus continuous two-season vaccination. Methods: The 2017–2019 from Center for Disease Control Prevention Shenzhen, Guangdong, China, included 880,119 individuals aged ≥65 years. participants were divided into vaccinated unvaccinated groups matched propensity scores with a 1:4 nearest-neighbor approach. Vaccinated further groups, 1:1....
CSCs (cancer stem cells) are a small subset of cells within tumour that possesses the characteristics and considered to be responsible for resistance chemoradiation. Identification through cell might have relevant clinical implications. In this study, SP (side population) were sorted from human ovarian cancer line by FACS determine whether cell-like present. A very fraction (2.6%) was detected in A2780 cells. possessed following characteristics: highly proliferative activity, marked ability...
Farmed grass carp (Ctenopharyngodon idella) at commercial size were transported to a natural lake for long-term depuration while being food deprived. The effect of time on the quality fish fillets was investigated based proximate compositions, textural parameters and flavour characteristics. results showed that protein lipids, but not carbohydrates, major source energy during starvation. Textural included hardness, springiness, gumminess cohesiveness increased significantly after depuration,...
Abstract Objectives To investigate laboratory markers for COVID‐19 progression in patients with different medical conditions. Methods We performed a multicenter retrospective study of 836 cases Hubei. avoid the collinearity among indicators, principal component analysis (PCA) followed by partial least squares discriminant (PLS‐DA) was to obtain an overview assessments. Multivariable logistic regression and multivariable Cox proportional hazards were respectively used explore risk factors...