A5101566284- Fungal Biology and Applications
- Polysaccharides and Plant Cell Walls
- Glioma Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Phytochemicals and Antioxidant Activities
- Ubiquitin and proteasome pathways
- interferon and immune responses
- Nutritional Studies and Diet
- Radiomics and Machine Learning in Medical Imaging
- Autophagy in Disease and Therapy
- Microbial Metabolites in Food Biotechnology
- Body Composition Measurement Techniques
- Psoriasis: Treatment and Pathogenesis
- Long-Term Effects of COVID-19
- Brain Tumor Detection and Classification
- Gastrointestinal motility and disorders
- Plant Genetic and Mutation Studies
- Polysaccharides Composition and Applications
- Orthopedic Infections and Treatments
- Nematode management and characterization studies
- Esophageal and GI Pathology
- Adipokines, Inflammation, and Metabolic Diseases
- Reconstructive Facial Surgery Techniques
- Exercise and Physiological Responses
- Histone Deacetylase Inhibitors Research
Third Affiliated Hospital of Zhengzhou University
2022-2025
Sichuan Agricultural University
2023-2025
Zhengzhou University
2022-2025
Henan Provincial Center for Disease Control and Prevention
2025
Xi'an Jiaotong University
2023-2024
Jinzhou Medical University
2024
Fifth Affiliated Hospital of Zhengzhou University
2024
Henan University
2023-2024
Ningbo University
2024
Chinese PLA General Hospital
2021
Cartilage regeneration is a complex physiological process. Synovial macrophages play critical immunomodulatory role in the acute inflammatory response surrounding joint injury. Due to contrasting differences and heterogeneity of macrophage, phenotype are key determinants healing after cartilage Biomaterials derived from extracellular matrix have been used for repair reconstruction variety tissues by modulating host macrophage response. However, effect decellularized (ECM) on has not...
Abstract The molecular mechanics Poisson–Boltzmann surface area (MM‐PBSA) method for GROMACS (g_mmpbsa) is an open‐source tool that capable of reading the trajectories generated by and calculating binding free energy using MM‐PBSA method. However, there are multiple force fields available users to choose from in software, also different solvent water models combine with chosen fields. These combinations parameters may significantly impact results g_mmpbsa calculation. Unfortunately, exact...
ABSTRACT RNF7 (Ring Finger Protein 7) is a key component of CRLs (Cullin‐RING‐type E3 ubiquitin ligases) and has been found to possess intrinsic anti‐ROS capabilities. Aberrant expression observed in various tumor types known significantly influence initiation progression. However, the specific role glioblastoma remains unclear. IDH (isocitrate dehydrogenase) mutations, which induce metabolic reprogramming result notable heterogeneity among glioma with different genotypes. Through analysis...
The physicochemical characteristics and fermentative behavior of original polysaccharides extracted after microwave cooking from Pleurotus cornucopiae during in vitro simulated digestion fecal fermentation were investigated.
Glioblastoma (GBM) is the most aggressive brain tumour in central nervous system, but current treatment very limited and unsatisfactory. PGE2 -initiated cAMP signalling via EP2 EP4 receptors involved tumourigenesis of multiple cancer types. However, whether or how contribute to GBM growth largely remains elusive.We performed comprehensive data analysis gene expression human samples determined their correlations through bioinformatics approaches. A time-resolved fluorescence energy transfer...
To investigate the potential risk factors for small-for-gestational-age (SGA) and appropriate-for-gestational-age (AGA) late-term infants, 100 cases of single full-term SGA infants delivered in Department Obstetrics, The First Affiliated Hospital Chongqing Medical University 2017 were enrolled as group. A total healthy AGA who born at same time with gestational age randomly included control perinatal postpartum adverse conditions two groups recorded, Apgar tests performed on all newborns 1...
Colorectal cancer (CRC) is one of the most common malignancies currently. Despite advances in drug development, survival and response rates CRC patients are still poor. In our previous study, a library comprised 1056 bioactive compounds was used for screening drugs that could suppress CRC. Lomerizine 2HCl, which an approved prophylactic migraines, selected studies. The results vitro vivo assays suggested lomerizine 2HCl suppresses cell growth promotes apoptosis cells. Moreover, inhibits...
Scope Diet and gut microbiota are involved in blood pressure regulations, but few studies have focused on the constipation patients. The study seeks to identify differences between hypertensive normotensive subjects patients, analyzes relationship dietary patterns pressure, explores mediation effects of microbiota. Methods results Gut microbial genera information 186 functional participants characterized by 16S rRNA sequencing a food frequency questionnaire. shows lower α‐diversity...
Obesity, a global health concern, is linked with numerous metabolic and inflammatory disorders.
Background Emerging evidence reveals that SARS-CoV-2 possesses the capability to disrupt gastrointestinal (GI) homeostasis, resulting in long-term symptoms such as loss of appetite, diarrhea, gastroesophageal reflux, and nausea. In current review, we summarized recent reports regarding effects COVID-19 (long COVID) on gastrointestine. Objective To provide a narrative review abundant clinical development management GI patients. Results Long-term persistent digestive are exhibited majority...
The innate immune system serves as the host's first line of defense against invading pathogens. Stimulator interferon genes (STING) is a key component this system, yet its relationship with glucose metabolism, particularly in antiviral immunity, remains underexplored. Metabolomics analysis was used for detecting metabolic alterations spleens from STING knockout (KO) and wild-type (WT) mice. Co-immunoprecipitation employed determining ubiquitination TKT. Mass spectrometry interaction proteins...
Abstract A translocator protein 18 kDa targeted radiotracer, N,N -diethyl-2-(2-(4-[ F]fluorophenyl)-5,7-dimethylpyrazolo[1,5-a] pyrimidin-3-yl) acetamide ([ F]FDPA), was automated synthetized and evaluated for cardiac inflammation imaging. Various reaction conditions an synthesis were systematically optimized. MicroPET/CT imaging performed on normal rats with myocardial infarction (MI). Normalized SUV ratios of [ F]FDPA to 13 N]NH 3 (NSRs) in different regions calculated normalize the uptake...
Immunotherapies, such as immune checkpoint inhibitors (ICIs) and chimeric antigen receptor-T (CAR-T) cells, are only efficient in a small proportion of tumor patients. One the major reasons for this is lack cell infiltration activation microenvironment (TME). Recent research reported that abundant bystander CD8
Retinal aging is one of the common public health problems caused by population and has become an important cause acquired vision loss in adults. The aim this study was to determine role human umbilical cord mesenchymal stem cells (hUCMSCs) delaying retinal ganglion cell (RGC) part network molecular mechanisms involved.
Objectives: Body water is fundamental in human metabolism. The current study aimed to evaluate the associations between body fluid rate (BFR) with plasma lipid profiles, including triglycerides, total cholesterol, and high-density lipoprotein (HDL)/low-density (LDL) among apparently healthy young Chinese adults. Methods: subjects were from phase 1 sample of 'Carbohydrate Alternatives Metabolic Phenotypes' study. After excluding those lacking blood samples, a 95 an average age 22.6 years...
Abstract Isocitrate dehydrogenase 1 ( IDH1 ) mutations are discovered in most grade Ⅱ gliomas (71%-78%), Ⅲ (62%-78%) and secondary glioblastomas (88%), have received lots of attention recent years. However, the tumor-promoting role wildtype still need to be further investigated. In this article, we found mRNA protein levels were both elevated glioma by using bioinformatic analysis, Besides, mutation reduced expression U87-R132H cell line. Furthermore, also increased along with increase...
RBX2 (RING box protein 2) is a key component of Cullin-RING-type E3 ubiquitin ligases (CRLs) and has been found to possess intrinsic anti-ROS capabilities. Aberrant expression observed in various tumor types known significantly influence initiation progression. However, the specific role glioblastoma remains unclear. IDH (isocitrate dehydrogenase) mutations, which induce metabolic reprogramming result notable heterogeneity among glioma with different genotypes. Through analysis public...