A5069657399- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Thermochemical Biomass Conversion Processes
- Lipoproteins and Cardiovascular Health
- Cancer Genomics and Diagnostics
- Cholesterol and Lipid Metabolism
- Caveolin-1 and cellular processes
- Microwave Dielectric Ceramics Synthesis
- Ferroelectric and Piezoelectric Materials
- Pharmacological Effects of Natural Compounds
- Epigenetics and DNA Methylation
- Dielectric properties of ceramics
- Chemical Looping and Thermochemical Processes
- Granular flow and fluidized beds
- Coal Properties and Utilization
- Iron and Steelmaking Processes
- Acute Myeloid Leukemia Research
- Rheumatoid Arthritis Research and Therapies
- Coal and Its By-products
- Autophagy in Disease and Therapy
- Computational Drug Discovery Methods
- Molecular Biology Techniques and Applications
- Recycling and Waste Management Techniques
- Cancer-related molecular mechanisms research
Zhujiang Hospital
2025
Southern Medical University
2022-2025
Hong Kong Baptist University
2025
Southeast University
2019-2024
Menlo School
2017-2024
Cell Technology (China)
2024
Illumina (United States)
2023
Grail (United States)
2017-2023
State Key Laboratory of Respiratory Disease
2023
Guangzhou Medical University
2023
In the Circulating Cell-free Genome Atlas (NCT02889978) substudy 1, we evaluate several approaches for a circulating cell-free DNA (cfDNA)-based multi-cancer early detection (MCED) test by defining clinical limit of (LOD) based on tumor allele fraction (cTAF), enabling performance comparisons. Among 10 machine-learning classifiers trained same samples and independently validated, when evaluated at 98% specificity, those using whole-genome (WG) methylation, single nucleotide variants with...
Abstract Esophageal squamous cell carcinoma (ESCC) is one of the most common malignant tumors with poor survival. It urgent to search for new efficient drugs good stability and safety clinical therapy. This study aims identify potential anticancer from a compound library consisting 429 natural products. Echinatin, isolated Chinese herb Glycyrrhiza uralensis Fisch , was found markedly induce apoptosis inhibit proliferation colony-formation ability in ESCC. Confocal fluorescence microscopy...
Abstract Osteoarthritis (OA) is a dynamic condition characterized by cartilage damage and synovial inflammation. Ozone (O 3 ) shows potential therapeutic effects owing to its anti‐inflammatory properties; however, high reactivity short half‐life substantially limit effectiveness in OA treatment. In this study, an ozone‐rich thermosensitive nanocomposite hydrogel loaded with D‐mannose developed for Briefly, O encapsulated nanoparticles (NPs) composed of perfluorotributylamine fluorinated...
Abstract Villin/gelsolin/fragmin superfamily proteins have been shown to function in tip-growing plant cells. However, genes encoding gelsolin/fragmin do not exist the Arabidopsis thaliana and rice (Oryza sativa) databases, it is possible that these are encoded by villin mRNA splicing variants. We cloned a 1006-bp full-length cDNA from Lilium longiflorum encodes 263–amino acid predicted protein sharing 100% identity with N terminus of 135-ABP (Lilium villin) except for six C-terminal amino...
Abstract Tumor metastasis is a complex process. A better understanding of the mechanistic underpinnings metastatic cascade could uncover approaches to prevent and target metastases. Here, we integrated transcriptomic profiling in primary esophageal squamous cell carcinoma (ESCC) matched lymph node tissues genome-wide CRISPR/Cas9 functional screening identify key drivers cancer metastasis. Anoctamin 1 (ANO1) expression was found be elevated tumors further increased tissues. High ANO1...
Pressurized oxy-fuel combustion is a solution to achieve low-cost CO2 capture and higher operating efficiency. The combination of pressurized technology biomass can negative emissions. However, co-combustion coal lacks mechanism understanding the studies on pollutant emissions are scarce. To investigate SO2 emission concentration, conversion rate fuel sulfur SO2, mass balance, content forms in ash biomass, series experiments were carried out horizontal tube furnace. experimental fuels...
The analytical validation is reported for a targeted methylation-based cell-free DNA multi-cancer early detection test designed to detect cancer and predict the signal origin (tissue of origin). A machine-learning classifier was used analyze methylation patterns >10 5 genomic targets covering >1 million sites. Analytical sensitivity (limit [95% probability]) characterized with respect tumor content by expected variant allele frequency determined be 0.07%-0.17% across five cases 0.51%...
Pleiotropic developmental regulators have been repeatedly linked to the evolution of anatomical novelties. Known mechanisms include cis-regulatory DNA changes that alter regulator transcription patterns or modify target-gene linkages. Here, we examine role another form regulation, translational control, in repeated self-fertile hermaphroditism Caenorhabditis nematodes. elegans hermaphrodites initiate spermatogenesis an otherwise female body through repression gene tra-2. This is mediated by...
Abstract Triple‐negative breast cancer (TNBC) is a subtype of with poor prognosis. The natural compound pristimerin has shown promising anti‐tumor effect. Here, it found that significantly triggered the activation autophagy initiation and induced apoptosis in TNBC. Mechanistically, RNA sequencing revealed activated mitogen‐activated protein kinase/extracelluar regulated kinases (MAPK/ERK) pathway. Drug affinity responsive target stability mass spectrometry techniques are employed to confirm...