A5034332194- Lipid Membrane Structure and Behavior
- Antimicrobial Peptides and Activities
- Extracellular vesicles in disease
- Antibiotic Resistance in Bacteria
- Glioma Diagnosis and Treatment
- Antibiotics Pharmacokinetics and Efficacy
- MicroRNA in disease regulation
- Probiotics and Fermented Foods
- Ubiquitin and proteasome pathways
- Pneumonia and Respiratory Infections
- Antibiotic Use and Resistance
- Nanoplatforms for cancer theranostics
- Cervical Cancer and HPV Research
- Fetal and Pediatric Neurological Disorders
- RNA Interference and Gene Delivery
- Surfactants and Colloidal Systems
- Energy Load and Power Forecasting
- Protein Hydrolysis and Bioactive Peptides
- Autophagy in Disease and Therapy
- Bacterial Identification and Susceptibility Testing
- interferon and immune responses
- Cancer, Hypoxia, and Metabolism
- Peptidase Inhibition and Analysis
- Monoclonal and Polyclonal Antibodies Research
- Emergency and Acute Care Studies
Third Affiliated Hospital of Zhengzhou University
2022-2025
Hunan Normal University
2020-2025
Henan Provincial Center for Disease Control and Prevention
2022-2025
Zhengzhou University
2023-2025
State University of New York
2021-2024
Xi'an Jiaotong University
2024
Lanzhou University
2024
Pulmonary Hospital of Lanzhou
2024
First Affiliated Hospital of Jinan University
2024
North China Electric Power University
2023
Abstract Bacterial infections, especially those from drug‐resistant strains, pose a significant threat to healing diabetic skin injuries, with current treatments being intricated and often unsatisfactory. Inspired by octopuses, biomimetic material using α‐cyclodextrin (α‐CD) polyethylene glycol (PEG) assembled graphene oxide end‐capped polyrotaxanes (GO‐PR) is developed, where α‐CD mimics the flexible tentacles of an octopus. Further, cationically modified polyethyleneimine (PEI) resemble...
Curcumin (CUR) is a natural food ingredient with known ability to target microbial cell membrane. In this study, the interactions of CUR different types model lipid bilayers (POPE, POPG, POPC, DOPC, and DPPE), mixtures (POPE/POPG), biological membrane mimics (Escherichia coli yeast) were investigated by all-atom explicit solvent molecular dynamics (MD) simulation. readily inserts into bilayer systems in liquid crystalline state, staying tails region near interface head tail. Parallel...
Antimicrobial peptides (AMPs) inactivate microorganisms by forming transmembrane pores in a cell membrane through adsorption and aggregation. Energetics of addition an AMP to pore is important for evaluation its formation growth. Such information essential the characterization ability membranes. This study quantifies potential mean force molecular dynamics (MD) simulation melittin, naturally occurring AMP, into DOPC/DOPG mixed bilayer, mimic bacterial membrane, different extents insertion...
Acinetobacter baumannii has emerged as an important pathogen causing a variety of infections. Using data from the China Surveillance Antimicrobial Resistance Program conducted biennially, we investigated secular changes in resistance 2917 isolates A. 2004 to 2014 differ antimicrobial agents.Pathogen samples were collected 17 20 hospitals located eastern, central, and western regions China. Minimum inhibitory concentrations (MICs) determined by 2-fold agar dilution method, susceptibility was...
Background: For anaphylaxis, a life-threatening allergic reaction, the incidence rate was presented to have increased from beginning of 21st century. Underdiagnosis and undertreatment anaphylaxis are public health concerns. Objective: This guideline aimed provide high-quality evidence-based recommendations for emergency management anaphylaxis. Method: The panel professionals fifteen medical areas selected twenty-five clinical questions formulated with supervision four methodologists. We...
Some amyloid related proteins/peptides are involved in aggregation and pore formation phospholipid membranes (cell membranes), which result a variety of neurological disorders such as Alzheimer's disease, Parkinson's disease Huntington disease. In this research, the mechanism by β (Aβ) peptides was investigated using molecular dynamics simulation simulating interaction Aβ(11-42) peptide, with lipid membrane potential mean force evaluated. A 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine...
Blood and semen are important body-fluids that carry exosomes for bioinformation transmission. Therefore, characterization of their proteomes is necessary understanding body-fluid-specific physiologic pathophysiologic functions. Using systematic multifactorial proteomic profiling, we characterized the exosome-free fractions from autologous blood three HIV-uninfected HIV-infected participants (total 24 samples). We identified exosome-based protein signatures specific to along with HIV-induced...
Acellular particles (extracellular vesicles and membraneless condensates) have important research, drug discovery, therapeutic implications. However, their isolation retrieval faced enormous challenges, impeding use. Here, a novel size-guided particle purification liquid chromatography (PPLC) is integrated into turbidimetry-enabled system for dye-free isolation, online characterization, of intact acellular from biofluids. The chromatographic separation different biofluids—semen, blood,...
Semen exosomes (SE) from HIV-uninfected (HIV−) individuals potently inhibit HIV infection in vitro. However, morphological changes target cells response to SE have not been characterized or the effect of use illicit substances, specifically psychostimulants, on function elucidated. The objective this study was evaluate infection, psychostimulant use, and both together SE-mediated regulation monocyte function. were isolated semen HIV− HIV-infected (HIV+) antiretroviral therapy (ART)-naive...
ABSTRACT RNF7 (Ring Finger Protein 7) is a key component of CRLs (Cullin‐RING‐type E3 ubiquitin ligases) and has been found to possess intrinsic anti‐ROS capabilities. Aberrant expression observed in various tumor types known significantly influence initiation progression. However, the specific role glioblastoma remains unclear. IDH (isocitrate dehydrogenase) mutations, which induce metabolic reprogramming result notable heterogeneity among glioma with different genotypes. Through analysis...
Cervical cancer is a common malignancy in women, with persistent human papillomavirus (HPV) infection as its primary cause. Understanding the progression from HPV to cervical crucial. Mathematical models play key role converting clinical trial data into long-term health forecasts, helping decision-makers tackle challenges posed by limited and uncertain outcomes. This paper reviews transmission dynamics advancements simulating leading cancer. It evaluates preventive control measures, focusing...
Melittin is a naturally occurring antimicrobial peptide that has the ability to kill bacterial cells through cell membrane penetration, leading pore formation. In this investigation, an all-atom molecular dynamics (MD) simulation been carried out describe interaction of two, four, or six peptides placed on surface 3:1 1,2-dioleoyl-sn-glycero-3-phosphocholine (DOPC)/1,2-di(9Z-octadecenoyl)-sn-glycero-3-phospho-(1′-rac-glycerol) (DOPG) lipid bilayer (a mimic membrane) corresponding...
BST-2 is a novel driver of cancer progression whose expression confers oncogenic properties to breast cells. As such, targeting in tumors may be an effective therapeutic approach against cancer. Here, we sought develop potent cytotoxic anti-cancer agent using the second-generation BST-2-based anti-adhesion peptide, B18, as backbone. To this end, designed series five B18-derived peptidomimetics. Among these, B18L, cationic amphiphilic α-helical peptidomimetic, was selected drug lead because...