A5052960857- HIV Research and Treatment
- MicroRNA in disease regulation
- Extracellular vesicles in disease
- Cannabis and Cannabinoid Research
- Immune Cell Function and Interaction
- Face and Expression Recognition
- Cytomegalovirus and herpesvirus research
- Tryptophan and brain disorders
- COVID-19 Clinical Research Studies
- Advanced Steganography and Watermarking Techniques
- Software Engineering Research
- Cancer-related molecular mechanisms research
- Distributed and Parallel Computing Systems
- HIV/AIDS Research and Interventions
- Neuroinflammation and Neurodegeneration Mechanisms
- HIV-related health complications and treatments
- Spam and Phishing Detection
- Cloud Computing and Resource Management
- HIV/AIDS drug development and treatment
- Software System Performance and Reliability
- Long-Term Effects of COVID-19
- RNA modifications and cancer
- Mobile Ad Hoc Networks
- Reproductive System and Pregnancy
- Mosquito-borne diseases and control
Texas Biomedical Research Institute
2020-2025
Saveetha University
2024-2025
Xavier Institute of Management and Entrepreneurship
2024
Jawaharlal Nehru Technological University, Hyderabad
2013-2023
Chaitanya Bharathi Institute of Technology
2022
Tulane University
2010-2019
Queen's University Belfast
2019
George Washington University
2013-2018
Andhra University
2017
Jawaharlal Nehru Technological University Anantapur
2017
Although the advent of combination anti-retroviral therapy (cART) has transformed HIV into a manageable chronic disease, an estimated 30-50% people living with (PLWH) exhibit cognitive and motor deficits collectively known as HIV-associated neurocognitive disorders (HAND). A key driver HAND neuropathology is neuroinflammation, where proinflammatory mediators produced by activated microglia macrophages are thought to inflict neuronal injury loss. Moreover, dysregulation microbiota-gut-brain...
Recreational and medical use of cannabis among human immunodeficiency virus (HIV)-infected individuals has increased in recent years. In simian (SIV)-infected macaques, chronic administration Δ9-tetrahydrocannabinol (Δ9-THC) inhibited viral replication intestinal inflammation slowed disease progression. Persistent gastrointestinal disease/inflammation been proposed to facilitate microbial translocation systemic immune activation promote Cannabinoids including Δ9-THC attenuated mouse colitis...
The composition of the gut microbiome reflects overall health status host. In this study, stool samples representing microbiomes from 6 gluten-sensitive (GS) captive juvenile rhesus macaques were compared with those healthy, age- and diet-matched peers. A total 48 both groups studied using V4 16S rRNA gene DNA analysis. Samples GS further characterized based on type diet administered: conventional monkey chow, i.e., wheat gluten-containing (GD), gluten-free (GFD), barley gluten-derived...
Cannabis use is frequent in HIV-infected individuals for its appetite stimulation and anti-inflammatory effects. To identify the underlying molecular mechanisms associated with these effects, we simultaneously profiled micro-RNA (miRNA) mRNA expression colon of chronically simian immunodeficiency virus (SIV)-infected rhesus macaques administered either vehicle (VEH/SIV; n=9) or Δ9- tetrahydrocannabinol (Δ9-THC; THC/SIV; n=8). Proinflammatory miR-130a, miR-222 miR-29b,...
The software is applied in various areas so the quality of very important. defect prediction (SDP) used to solve issues and enhance quality. robustness reliability are major concerns existing SDP approaches. Hence, this paper, hybrid optimization-based neural network (Optimized NN) developed for effective detection defects software. two main steps involved Optimized NN-based feature selection utilizing NN. data fed forwarded module, where relief algorithm selects significant features...
Although patients with human immunodeficiency virus type 1 infection who are receiving antiretroviral therapy and those long-term, nonprogressive (LTNPs) usually have undetectable viremia, persists in tissue reservoirs throughout infection. However, the distribution magnitude of viral persistence replication tissues has not been adequately examined. Here, we used simian (SIV) macaque model to quantify compare RNA DNA small (jejunum) large (colon) intestine LTNPs. In LTNPs chronic infection,...
Our studies have demonstrated that chronic Δ9-tetrahydrocannabinol (THC) administration results in a generalized attenuation of viral load and tissue inflammation simian immunodeficiency virus (SIV)-infected male rhesus macaques. Gut-associated lymphoid is an important site for HIV replication can impact disease progression. We used systems approach to examine the duodenal immune environment 4- 6-year-old monkeys inoculated intravenously with SIVMAC251 after 17 months THC (0.18–0.32 mg/kg,...
Persistent gastrointestinal inflammation, a hallmark of progressive HIV/SIV infection, causes disruption the epithelial barrier, microbial translocation, and generalized immune activation/inflammation driving AIDS progression. Apart from protein regulators, recent studies strongly suggest critical roles for microRNAs (miRNAs) in regulating managing certain aspects inflammatory process. To examine their immunoregulatory role, we profiled miRNA expression colon 12 chronic SIV-infected 4...
Intestinal epithelial barrier dysfunction, a hallmark of HIV/SIV infection, persists despite viral suppression by combination antiretroviral therapy (cART). Emerging evidence suggests critical role for long noncoding RNAs (lncRNAs) in maintaining homeostasis. We simultaneously profiled lncRNA/mRNA expression exclusively colonic epithelium (CE) SIV-infected rhesus macaques (RMs) administered vehicle (VEH) or Δ-9-tetrahydrocannabinol (THC). Relative to controls, fewer lncRNAs were up-...
Abstract Intestinal epithelial barrier dysfunction is a well-known sequela of HIV/SIV infection that persists despite antiretroviral therapy. Although inflammation triggering factor, the underlying molecular mechanisms remain unknown. Emerging evidence suggests function epigenetically regulated by inflammation-induced microRNAs (miRNAs). Accordingly, we profiled and characterized miRNA/mRNA expression exclusively in colonic epithelium identified 46 differentially expressed miRNAs (20...
As robots continue to create long-term maps, the amount of information that they need handle increases over time. In terms place recognition, this implies number images being considered may increase until exceeding computational resources robot. paper we consider a scenario where, given multiple independent large possibly from different cities or locations, robot must effectively and in real time decide whether it can localize itself one those known maps. Since be handled by such system is...
Most existing methods for automatic bilingual dictionary induction rely on prior alignments between the source and target languages, such as parallel corpora or seed dictionaries. For many language pairs, supervised are not readily available. We propose an unsupervised approach learning a pair of languages given their independently-learned monolingual word embeddings. The proposed method exploits local global structures in vector spaces to align them that similar words mapped each other....