A5100340344- Immune cells in cancer
- Cancer-related molecular mechanisms research
- Immune Cell Function and Interaction
- MicroRNA in disease regulation
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Cancer, Lipids, and Metabolism
- Cancer Mechanisms and Therapy
- Immune Response and Inflammation
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- Ferroptosis and cancer prognosis
- Autophagy in Disease and Therapy
- Colorectal Cancer Screening and Detection
- Cancer Cells and Metastasis
- Chemokine receptors and signaling
- Epigenetics and DNA Methylation
- RNA Research and Splicing
- Healthcare and Venom Research
- Lung Cancer Diagnosis and Treatment
- PI3K/AKT/mTOR signaling in cancer
- Cytokine Signaling Pathways and Interactions
- Colorectal Cancer Surgical Treatments
- Mesenchymal stem cell research
Shanghai University of Traditional Chinese Medicine
2016-2025
Roche (Switzerland)
2025
Duke University
2024
Ruijin Hospital
2018-2024
Sichuan University
2016-2024
Chongqing Medical University
2019-2024
Children's Hospital of Chongqing Medical University
2024
Duke University Hospital
2024
Duke Medical Center
2024
University of Science and Technology of China
2023-2024
Abstract The acidic microenvironment of tumors significantly reduces the anti‐tumor effect immunotherapy. Herein, a hierarchically structured fiber device is developed as local drug delivery system for remodeling tumor (TME) to improve therapeutic Proton pump inhibitors in matrix can be sustainedly released inhibit efflux intracellular H + from cells, resulting TME. targeted micelles and M1 macrophage membrane‐coated nanoparticles internal cavities induce immunogenic cell death (ICD) cells...
Long non-coding RNAs (lncRNAs) have been shown to be implicated in the complex network of cancer including malignant melanoma and play important roles tumorigenesis progression. However, their functions downstream mechanisms are largely unknown. This study aimed investigate whether BRAF-activated RNA (BANCR), a novel potential regulator cell, participates proliferation elucidate underlying mechanism this process. We found that BANCR was abnormally overexpressed human cell lines tissues,...
Combining chemotherapy and immunotherapy is a promising strategy for the treatment of non-small cell lung cancer (NSCLC) metastasis. However, platinum-based chemotherapeutics immune checkpoint blockade-based have toxic side effects limitations. Ursolic acid (UA) astragaloside IV (AS-IV) are natural compounds with anticancer activity sourced from Traditional Chinese medicine (TCM). their poor water solubilities targeted deletions limit medicinal value. In this study, we fabricated hyaluronic...
Ethnopharmacological relevance: Sanguinarine (SAG), a natural benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis Linn. (Bloodroot), possesses potential anticancer activity. Lung carcinoma is chief cause malignancy-related mortality in China. Non-small cell lung (NSCLC) main subtype and accounts for about eighty-five percent this disease. Current treatment controlling curing NSCLC remains deficient.The role underlying mechanism SAG repressing growth metastasis were...
MicroRNAs (miRNAs) are important regulators of pathobiological processes in various cancer. In the present study, we demonstrated that miR-93 expression was significantly up-regulated gastric cancer tissues compared with matched normal mucosal tissues. High associated lymph node metastasis and tumor-node-metastasis (TNM) stage. Functionally, ectopic promoted cell proliferation, migration, invasion, EMT phenotypes, repressed apoptosis G1 cycle arrest vitro, tumor formation vivo. We further...
Objective . This study was aimed at investigating the prognostic significance of Baculoviral IAP repeat containing 5 (BIRC5) in lung adenocarcinoma (LAD) lacking EGFR, KRAS, and ALK mutations (triple-negative (TN) adenocarcinomas). Methods The gene expression profiles were obtained from Gene Expression Omnibus (GEO). identification differentially expressed genes (DEGs) performed by GeneSpring GX. set enrichment analysis (GSEA) used to execute ontology function pathway analysis. protein...
The present study examined the involvement of autophagy as a mechanism in protective effect quercetin (QUE) on atherosclerosis (AS) ApoE‑/‑ mice. An AS model was established by feeding mice high‑fat diet (HFD). Mice were divided into four experimental groups: model, QUE, 3‑methyladenine (3‑MA) and QUE + 3‑MA groups. Additionally, age‑matched wild‑type C57BL/6 used Control group. Autophagosomes aorta using transmission electron microscope. Aorta pathology, serum lipid accumulation collagen...
Ferroptosis, a type of iron-dependent oxidative cell death caused by excessive lipid peroxidation, is emerging as promising cancer therapeutic strategy. Solasonine has been reported potential compound in tumor suppression, which closely linked to ferroptosis. However, ferroptosis solasonine insufficiently identified and elaborated lung adenocarcinoma, fatal disease with high morbidity mortality rates. First, the biochemical morphological changes Calu-1 A549 cells exposed are observed using...
Background Toll-like receptors (TLRs) such as TLR2, TLR4, and TLR9 contribute to the pathogenesis of polymicrobial sepsis. These TLRs signal via common myeloid differentiation factor 88 (MyD88)-dependent pathways. TLR4 also signals through MyD88-independent but TIR domain-containing adaptor inducing interferon-β-mediated transcription (Trif)-dependent pathway. The role two signaling pathways in cardiac dysfunction during sepsis endotoxin shock is unknown. Methods Sepsis was generated by...
The aim of this study is to investigate whether metastasis-associated lung adenocarcinoma transcript 1 (MALAT-1) can be used as a potential therapy target for human esophageal squamous cell carcinoma. MALAT-1 expression levels were detected in 137 paired EC samples and adjacent nonneoplastic tissues. Human carcinoma lines EC9706 KYSE150 transfected with small interference RNA. Cell proliferation, migration/invasion ability, cycle, apoptosis assessed. expressed higher cancer tissues when...
Background: Lung cancer is one of the most common causes cancer-related deaths worldwide, metabolic disorders are also a problem that puzzles mankind. SREBP overexpressed in non-small-cell lung (NSCLC) and key regulator lipid synthesis. However, mechanisms by which regulates proliferation, migration invasion NSCLC remain unclear. Materials Methods: CCK-8, colony formation assay, soft agar scratch wound healing assay transwell assays were performed to detect cells, respectively. In addition,...
Abstract Background Expansion-mediated replicative senescence and age-related natural have adverse effects on mesenchymal stem cell (MSC) regenerative capability functionality, thus severely impairing the extensive applications of MSC-based therapies. Emerging evidences suggest that microRNA-34a (miR-34a) has been implicated in process MSC senescence; however, molecular mechanisms with regard to how miR-34a influencing remain largely undetermined. Methods MiR-34a expression MSCs was...
Tumor-associated macrophage (TAM)-mediated angiogenesis in the tumor microenvironment is a prerequisite for lung cancer growth and metastasis. Therefore, targeting TAMs, which block angiogenesis, expected to be breakthrough controlling metastasis of cancer. In this study, we found that Sanguinarine (Sang) inhibits subcutaneously transplanted tumors Lewis mice. Furthermore, inhibited proliferation, migration, lumen formation HUVECs expression CD31 VEGF by regulating polarization M2...
Klebsiella pneumoniae is an opportunistic pathogen and poses a serious threat to the livestock industry human health. Therefore, it necessary investigate prevalence of K. in agricultural settings. In this study, fecal environmental samples from poultry farms were collected, antibiotic resistance genetic diversity determined through antimicrobial susceptibility testing, whole‐genome sequencing (WGS), bioinformatics analysis. Resistance phenotype analysis 99 strains indicated that all them...
To test whether retinal pigment epithelial (RPE) cells are able to induce myeloid-derived suppressor cell (MDSC) differentiation from bone marrow (BM) progenitors.BM were cocultured with or without RPE in the presence of GM-CSF and IL-4. Numbers resultant MDSCs assessed by flow cytometry after 6 days incubation. The ability cell-induced inhibit T was evaluated a CFSE-based T-cell proliferation assay. explore mechanism which MDSC differentiation, PD-L1-deficient blocking antibodies against...
The purpose of the current study was to investigate mechanism by which fisetin improves atherosclerosis (AS) regulating lipid metabolism and senescence in apolipoprotein E‑deficient (apoE<sup>‑/‑</sup>) mice. An AS model established feeding apoE<sup>‑/‑</sup> mice a high‑fat diet. Mice were randomly divided into group (n=18), group (n=18) atorvastatin (n=18). control (n=18) composed wild‑type C57BL/6 same age genetic background. groups respectively treated with aqueous solutions...