Tumor-associated macrophages (TAMs) play a critical role in modulating the tumor microenvironment and promote metastases. Our studies have demonstrated that ginsenoside Rh2 (G-Rh2), monomeric compound extracted from ginseng, is promising anti-tumor agent lung cancer cells. However, it remains unclear whetherG-Rh2 can modulate differentiation of TAMs its interaction with microenvironment. In this study, we investigated how G-Rh2 regulates phenotype affects migration non-small cell (NSCLC)...

Ethnopharmacological relevance: Sanguinarine (SAG), a natural benzophenanthridine alkaloid derived from the root of Sanguinaria canadensis Linn. (Bloodroot), possesses potential anticancer activity. Lung carcinoma is chief cause malignancy-related mortality in China. Non-small cell lung (NSCLC) main subtype and accounts for about eighty-five percent this disease. Current treatment controlling curing NSCLC remains deficient.The role underlying mechanism SAG repressing growth metastasis were...

Ferroptosis, a type of iron-dependent oxidative cell death caused by excessive lipid peroxidation, is emerging as promising cancer therapeutic strategy. Solasonine has been reported potential compound in tumor suppression, which closely linked to ferroptosis. However, ferroptosis solasonine insufficiently identified and elaborated lung adenocarcinoma, fatal disease with high morbidity mortality rates. First, the biochemical morphological changes Calu-1 A549 cells exposed are observed using...

(-)-Guaiol, generally known as an antibacterial compound, has been found in many medicinal plants. Its roles tumor suppression are still under investigation. In the study, we mainly focused on exploring its applications dealing with non-small cell lung cancer (NSCLC) and underlying mechanisms. Here, show that (-)-Guaiol significantly inhibits growth of NSCLC cells both vitro vivo. Further high throughput analysis reveals RAD51, a pivotal factor homologous recombination repair, is potential...

Tumor-associated macrophage (TAM)-mediated angiogenesis in the tumor microenvironment is a prerequisite for lung cancer growth and metastasis. Therefore, targeting TAMs, which block angiogenesis, expected to be breakthrough controlling metastasis of cancer. In this study, we found that Sanguinarine (Sang) inhibits subcutaneously transplanted tumors Lewis mice. Furthermore, inhibited proliferation, migration, lumen formation HUVECs expression CD31 VEGF by regulating polarization M2...

ABSTRACT TME is a core player in the development of cancerous lesion, immune evasive potential and its response to therapy. Sphingolipid metabolism, which governs number cellular processes, has been recognised as involved control heterogeneity within TME. metabolism‐related genes prevalent LUAD LUSC were identified using transcriptomic analysis clinical samples from TCGA GTEx databases. Lasso regression survival SVM Etra Application employed machine learning algorithms determine patient...

Lung cancer is the leading cause of cancer-related deaths globally. Prolonged targeted therapy use can lead to drug resistance and target mismatches, necessitating more effective safer treatment strategies. Recent research has focused on tumor microenvironment, which includes immune stromal cells that play roles in proliferation, metastasis, neovascularization. Tumor-associated macrophages (TAMs) are key promoting invasion, escape. Their infiltration density lung tissue a poor prognostic...

Little is known about Yu-Ping-Feng (YPF), a typical Chinese herbal decoction, for its antitumor efficacy in non-small-cell lung cancer (NSCLC). Here, we found that YPF significantly inhibited the growth of Lewis cancer, prolonged survival tumor-bearing mice, promoted NK cell tumor infiltration, increased population cells spleen, and enhanced cell-mediated killing activity. The suppression tumors by was reversed depletion cells. Furthermore, downregulated expression TGF-β, indoleamine...

Myeloid-derived suppressor cells (MDSCs) play an important role in the tumor-induced immunosuppressive microenvironment and have been linked with tumor development, proliferation, resistance to treatment. Therefore, therapies that target MDSCs, such as sanguinarine (SNG), are now being considered potential treatments for lung cancer. However, of SNG regulating immune response cancer is still not clear. In view this, we evaluated mechanism involved antitumor immunoregulatory therapy a Lewis...

Objective: To evaluate the effect of CYP2D6 *10 polymorphism (C 100C>T, rs1065852) on clinical outcomes female Asian breast cancer patients with tamoxifen adjuvant treatment. Methods: Meta-analysis retrospective cohort studies published in July 2017 was performed. Fifteen 1,794 were included, using strict eligibility requirements. Associations disease-free survival (DFS), overall (OS) and recurrence rate after intake, investigated through random effects models. Results: found to have DFS...

(−)-Guaiol, a sesquiterpene alcohol with the guaiane skeleton, has been found in many Chinese medicinal plants and reported to comprise various natural products that are well known for their antibacterial activities. Previously, we have shown its antitumor activity by inducing autophagy NSCLC cells. However, potential mechanism is still under our investigation. Here, data from western blotting assays showed that, cells, (−)-Guaiol significantly blocked mTORC2-AKT signaling suppressing mTOR...

Introduction: The expression of USP22 has been demonstrated to play a pivotal role in solid tumors. However, the prognostic value still remains unknown. Materials and methods: A systematic meta-analysis was performed assess cancers. literature collection conducted from inception June 8, 2017 by searching PubMed, Cochrane Library, Embase, Ovid Web Science databases. pooled hazard ratio (HR) odds (OR) were used correlate high with overall survival (OS) clinicopathological features. Results:...

Sanguinarine (SNG) is a benzophenanthridine alkaloid obtained from the roots of Sanguinaria canadensis and has an anticancer effect. The aim this study was to explore mechanism SNG in inhibiting macrophages via regulating exosomes derived lung carcinoma cells reduce metastasis proliferation carcinoma.Human cancer (A549 cells) were treated with 4μM SNG. Exosomes A549 extracted supernatant, THP-1 cultured exosomes. Then, supernatant collected cells. Cell measured plate clone formation CCK-8...

Chinese herbal Fu‐Zheng‐Qu‐Xie (FZQX) prescription has been found to improve the immune function and survival of patients with early‐stage lung cancer. However, therapeutic efficacy needs be evaluated objectively, precise mechanism remains unclear. In present study, a double‐center, prospective cohort study was carried out assess clinical FZQX in preventing recurrence metastasis postoperative adenocarcinoma. Our results indicated that could significantly reduce 3‐year rate life quality....

Lung cancer is one of the most common causes cancer-associated mortality worldwide. Upregulation kinesin family member 15 (KIF15) expression has been observed in non-small cell lung (NSCLC), and high levels KIF15 are associated with a poor prognosis patients NSCLC. However, to best our knowledge, mechanisms by which regulates apoptosis, migration invasion NSCLC remain unclear.Cell Counting Kit-8, flow cytometry Transwell assays were performed determine proliferation, apoptosis cells,...

Yu-Ping-Feng (YPF) formula is a classical prescription used for enhancing the body’s immunity function in traditional Chinese medicine (TCM). In clinical practice, YPF has been reported to exhibit antilung cancer and immunomodulatory effect. However, relationship between them remains unclear. The present study aimed investigate effect of its immune-related mechanisms. C57BL/6 tumor-bearing mice model was established randomly divided into group control group. Tumor volume, spleen weight,...

To explore the efficacy of long-term use Chinese herbal medicine (CHM) on survival time lung cancer.We conducted a retrospective cohort study cancer patients. A propensity score matching (PSM) was performed to balance covariates. Progression-free (PFS) primary endpoint and overall (OS) secondary endpoint. Patients who received CHM therapy from initial date diagnosis were included in group. not treated with during same interval categorized control Cox regression model used prognostic factors...

Accurately predicting the risk of recurrence in stage I-IIIA non-small cell lung cancer (NSCLC) after resection is critical treatment process. This study aimed to establish a novel nomogram identify patients with disease progression based on clinical characteristics, peripheral T-lymphocyte subsets, and CD16+56 natural killer (NK) cells.A total 306 NSCLC from Shanghai Municipal Hospital Traditional Chinese Medicine between 2010 2020 who met inclusion exclusion criteria January 2011 December...

BACKGROUND Lung adenocarcinoma (LUAD) is the predominant histological type of lung cancer with high morbidity and mortality. Ferroptosis regarded as a new pattern programmed cell death concerned progression characterized by lipid peroxidation. Nevertheless, prognostic role ferroptosis-related genes for LUAD warrant to be explored. MATERIAL AND METHODS RNA sequencing relevant clinical patient data were obtained from public-access databanks. A model was constructed through LASSO Cox regression...

Chemotherapy is widely used for non-small cell lung cancer (NSCLC) patients at a late stage; however, NSCLC often acquire resistance to chemotherapeutic drugs, thus limiting the therapy efficacy. Melittin, major component of bee venom, possesses anti-tumor activity in various cells. Here, we examined effects melittin on A549/DDP cisplatin-resistant adenocarcinoma cells and xenografts formed from this line investigated possible target melittin. Treatment with resulted induction apoptosis,...

Lung cancer is a malignancy characterized by high morbidity and mortality, with lung adenocarcinoma being the most prevalent subtype. Our preliminary studies have demonstrated that Juan-Liu-San-Jie (JLSJ) prescription, Traditional Chinese Medicine possesses anti-lung properties. However, molecular mechanism underlying therapeutic effects of JLSJ prescription for remains incompletely elucidated. To address knowledge gap, present study employed network pharmacology to identify potential...

Fu-Zheng-Qu-Xie (FZQX) decoction is a traditional Chinese herbal prescription for the treatment of lung cancer and exerts proapoptotic immunomodulatory effects. It has been clinically suggested to be effective in improving survival postoperative early-stage adenocarcinoma (LUAD), but mechanism remains unclear. In this study, we used network pharmacology coupled with metabolomics approaches explore pharmacological action FZQX against recurrence metastasis LUAD. Network analysis showed that...

BACKGROUND Lung adenocarcinoma (LUAD) is the most common type of lung cancer, which poses a serious threat to human life and health. -(-)Guaiol, an effective ingredient many medicinal herbs, has been shown have high potential for tumor interference suppression. However, knowledge pharmacological mechanisms still lacking adequate identification or interpretation. MATERIAL AND METHODS The genes LUAD patients collected from TCGA were analyzed using limma WGCNA. In addition, targets (-)-Guaiol...

Objective To discuss interventional biopsy histology of the liver lesions pathological di-agnosis and clinical evaluation. Methods 20 cases treated with percutaneous CT-guided cutting needle extract lesions, With 10% formaldehyde solution fixed specimens sent to patholog-ical examination room. Results All patients successful puncture, No significant complications. Of these,hepatocellular carcinoma 15 cases; 1 mild heterotypic cells; Mild one atypical hyper- plasia; Two chronic interstitial...