A5103103153- Neurological Disease Mechanisms and Treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Vestibular and auditory disorders
- Traditional Chinese Medicine Analysis
- Nerve injury and regeneration
- Advanced Neuroimaging Techniques and Applications
- Axon Guidance and Neuronal Signaling
- Multiple Sclerosis Research Studies
- Endometrial and Cervical Cancer Treatments
- Pharmacological Effects of Natural Compounds
- Hearing, Cochlea, Tinnitus, Genetics
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Ferroptosis and cancer prognosis
- Immune Response and Inflammation
- Hepatitis B Virus Studies
- Sarcoma Diagnosis and Treatment
- Gastric Cancer Management and Outcomes
- Renal cell carcinoma treatment
- Stress Responses and Cortisol
- Acute Ischemic Stroke Management
- Immunotherapy and Immune Responses
- Natural product bioactivities and synthesis
- Cerebral Venous Sinus Thrombosis
Capital Medical University
2016-2025
Affiliated Zhongshan Hospital of Dalian University
2025
Fudan University
2012-2024
Huzhou Central Hospital
2024
Huzhou University
2024
Huashan Hospital
2020-2024
Shaanxi Provincial Hospital of Traditional Chinese Medicine
2024
Wenzhou Medical University
2022-2023
Anhui University of Traditional Chinese Medicine
2019-2023
Capital University
2017-2023
The scientific literature to date lacks population-based studies on the demographics, clinical features, and survival of patients with adenoid cystic carcinoma (ACC) different anatomic sites.The authors identified 5349 who had ACC major salivary glands (N = 1850), minor 2077), breast 696), skin 291), lung bronchus 203), female genital system 132), eye orbit 100) from Surveillance, Epidemiology, End Results (SEER) registry. Differences in were assessed.ACC was associated younger age at...
Angiogenesis and vasculogenic mimicry (VM) are thought to be the predominant processes ensuring tumor blood supply during growth metastasis of glioblastoma (GBM). Celastrol has potential anti-glioma effects, however mechanisms underlying these effects remain unclarified. Recent studies have shown that PI3K/Akt/mTOR signaling pathway is closely related angiogenesis VM formation. In present study, we demonstrated, for first time, celastrol eliminated formation by blocking this in glioma cells....
2,3,5,6-Tetramethylpyrazine (TMP) as an active ingredient extracted from a traditional Chinese herbal medicine Ligusticum chuanxiong Hort . has been proved to penetrate blood-brain barrier (BBB) and show neuroprotective effects on cerebral ischemia. However, whether TMP could regulate astrocytic reactivity facilitate neurovascular restoration in the subacute ischemic stroke needs be urgently verified. In this research, permanent occlusion of middle artery (MCAO) model was conducted (10, 20,...
The frontline tyrosine kinase inhibitor (TKI) imatinib has revolutionized the treatment of patients with chronic myeloid leukemia (CML). However, drug resistance is major clinical challenge in CML. Hedgehog (Hh) signaling pathway and autophagy are both related to tumorigenesis, cancer therapy, resistance. This study was conducted explore whether Hh could regulate CML cells simultaneously regulating induce cell death drug-sensitive or -resistant BCR-ABL+ cells. Our results indicated that...
Abstract Relationships among clinical characteristics, iron metabolism and neurotransmitters in Parkinson disease (PD) patients with restless legs syndrome (RLS) remains unclear. We divided 218 into PD no RLS (PD-RLS PD-NRLS) groups by RLS-rating scale (RLS-RS) score. Motor non-motor symptoms were rated related scales. Iron proteins, cerebrospinal fluid (CSF) serum measured. PD-RLS frequency was 40.37%. group had longer duration, higher stage scores of motor symptoms, depression, anxiety,...
Ischemic stroke results in demyelination that underlies neurological disfunction. Promoting oligodendrogenesis will rescue the injured axons and accelerate remyelination after stroke. Microglia react to ischemia/hypoxia polarize M1/M2 phenotypes influencing myelin injury repair. Tetramethylpyrazine (TMP) has neuroprotective effects treating cerebrovascular disorders. This study aims evaluate whether TMP promotes renovation of damaged brain tissues especially on modulates microglia following...
Secretory clusterin (sClu) is an anti-apoptotic protein that plays a role in protecting cells from Tumour-necrosis factor (TNF)-alpha-induced apoptosis. The aim of the present study was to investigate molecular mechanisms underlying effect sClu on TNF-alpha-induced apoptosis breast cancer cells. wild-type p53 expressing MCF-7 cell line engineered overexpress (MCF-7/sClu), whereas MDA-MB-231 with mutant transfected silencing siRNA (MDA-MB-231/sClu siRNA). effects overexpression and...
Enriched environment (EE) with a complex combination of sensorimotor, cognitive and social stimulations has been shown to enhance brain plasticity improve recovery functions in animal models stroke. The present study extended these findings by assessing whether the three-phase EE intervention paradigm would neurovascular remodeling following ischemic Male Sprague-Dawley rats were subjected permanent middle cerebral artery occlusion (MCAO). A was designed terms different periods ischemia...
Bu Shen Yi Sui capsule (BSYS) is a traditional Chinese medicine prescription that has shown antineuroinflammatory and neuroprotective effects in treating multiple sclerosis (MS) its animal model of experimental autoimmune encephalomyelitis (EAE). Microglia play an important role neuroinflammation. The M1 phenotype microglia involved the proinflammatory process disease, while M2 plays anti-inflammatory role. Promoting polarization to MS/EAE promising therapeutic strategy. This study aimed at...
Our previous studies reported that SHC SH2-domain binding protein 1 (SHCBP1) functions as an oncogene via promoting cell proliferations in synovial sarcoma (SS) cells. However, whether SHCBP1 has any effect on tumor metastasis remains unexplored. The expression of was analyzed 76 SS tissues and two lines by immunohistochemistry real-time RT-PCR. relationship between the clinicopathological features investigated. role adhesion, migration, invasion angiogenesis explored Wound healing,...
The pathological presence of tissue factor (TF) in cancer cells promotes tumor-initiated thrombosis and metastasis. We found that TF is aberrantly present large percentage aggressive triple negative breast (TNBC) pancreatic adenocarcinoma (PaC), two most lethal forms malignancy urgently need effective treatment. expression TNBC clustered with higher levels vimentin, basal-type keratins KRT5/14 caveolin-1 but lower luminal-type biomarkers. developed a novel specific anti-TF therapeutic...
Houshiheisan (HSHS), a classic prescription in traditional Chinese medicine (TCM), has remarkable efficacy the treatment of ischemic stroke.To investigate pro-angiogenic effect and molecular mechanism HSHS for stroke recovery.The rat permanent middle cerebral artery occlusion (pMCAO) model was constructed by suture method, (5.25 or 10.5 g/kg) Ginaton (28 mg/kg) intragastrically administrated at 6 h after modeling which remained 7 consecutive days. Pathological evaluation conducted...
Identifying the alterations of cerebral gray and white matter is an important prerequisite for developing potential pharmacological therapy stroke. This study aimed to assess changes after permanent middle artery occlusion (pMCAO) in rats using magnetic resonance imaging (MRI), correlate them with behavior performance. Rats were subjected pMCAO or sham surgery reared 30 days. Motor cognitive function examined by gait Morris water maze (MWM) tests, respectively. Multimodal MRI was conducted...
Background and purpose: Several clinical trials have indicated that the use of canagliflozin increases risk lower extremity amputation. Although US Food Drug Administration (FDA) has withdrawn its black box warning about amputation for canagliflozin, still exists. We sought to estimate association between hypoglycemic medications, especially sodium-glucose co-transporter-2 inhibitors (SGLT2is), adverse events (AEs) before irreversible outcome as a promising early warning, based on FDA...
Abstract Background The evidence of sex disparity in acute respiratory distress syndrome (ARDS) is scarce and varies widely. Objective This observational, retrospective study aimed to determine the effect on sepsis-related ARDS other short outcomes critically ill patients with sepsis. Methods A total 2111 adult sepsis who were admitted three central intensive care units (ICUs) Wuhan Tongji Hospital between 2012 2022 included our analysis. Sex was considered as an exposure factor, primary...