A5077146872- Multiple Sclerosis Research Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Anesthesia and Sedative Agents
- Traditional Chinese Medicine Studies
- Oral microbiology and periodontitis research
- Acute Ischemic Stroke Management
- Oral Health Pathology and Treatment
- Neuroscience and Neuropharmacology Research
- Cytokine Signaling Pathways and Interactions
- Pharmacological Effects of Natural Compounds
- Temporomandibular Joint Disorders
- Intensive Care Unit Cognitive Disorders
- MicroRNA in disease regulation
- Nerve injury and regeneration
- Peripheral Neuropathies and Disorders
- Hemodynamic Monitoring and Therapy
- Laser Applications in Dentistry and Medicine
- Anesthesia and Neurotoxicity Research
- Endodontics and Root Canal Treatments
- Salivary Gland Disorders and Functions
- Neurological Disease Mechanisms and Treatments
- Immunotherapy and Immune Responses
- Thermal Regulation in Medicine
- Sphingolipid Metabolism and Signaling
Capital Medical University
2013-2023
Capital University
2023
Beijing Shijitan Hospital
2023
Beijing Tian Tan Hospital
2013-2022
Shanghai Stomatological Hospital
2019-2020
Binzhou People's Hospital
2019
Sun Yat-sen University
2010
Central University of Finance and Economics
2009
University of Alberta
2001-2004
Cerebral edema develops very early after the onset of focal cerebral ischemia and may be a major factor in disability an acute ischemic stroke. There have been limited studies on usefulness antiedemic agents as neuroprotective setting ischemia. We tested effects new potent nonpeptide vasopressin receptor V(1) antagonist, SR-49059, embolic stroke model rats.Focal injury was induced by embolizing preformed clot into middle artery (MCA). Infarction volume measured at 48 hours MCA occlusion....
Bu Shen Yi Sui capsule (BSYS) is a traditional Chinese medicine prescription that has shown antineuroinflammatory and neuroprotective effects in treating multiple sclerosis (MS) its animal model of experimental autoimmune encephalomyelitis (EAE). Microglia play an important role neuroinflammation. The M1 phenotype microglia involved the proinflammatory process disease, while M2 plays anti-inflammatory role. Promoting polarization to MS/EAE promising therapeutic strategy. This study aimed at...
T helper (Th) 17 and regulatory (Treg) cells play a critical role in the pathogenesis of multiple sclerosis (MS) disease. Bu Shen Yi Sui Capsule (BSYSC), traditional Chinese medicine formula, has been used clinically for treatment MS patients China. To evaluate neuroprotective effects underlying mechanisms BSYSC on MS, experimental autoimmune encephalomyelitis (EAE) model C57BL/6 mice was induced with myelin oligodendrocyte glycoprotein (MOG) 35–55. Th17 Treg related cytokines were detected...
Inflammatory reactions occurring in the brain after ischemia may contribute to secondary damage. In present study, effects of minocycline, an anti-inflammatory agent, alone or combination with mild hypothermia on focal embolic cerebral have been examined.Focal ischemic injury was induced by embolizing a preformed clot into middle artery (MCA). Infarction volume measured at 48 h injury. Mortality also recorded.Delayed administration minocycline delayed plus reduced infarction significantly....
In neuromyelitis optica (NMO), one of the underlying pathogenic mechanisms is formation antigen-antibody complexes which can trigger an inflammatory response by inducing infiltration neutrophils in lesions. Epithelial neutrophil-activating peptide 78 (ENA 78), known as Chemokine (C-X-C motif) ligand 5 (CXCL5), belongs to ELR-CXCL family. It recruits and activates neutrophils. The aim this study was evaluate ENA 78, IL-1β TNF-α plasma levels multiple sclerosis (MS) (NMO) patients. were...
Background/Aims. Multiple sclerosis (MS) is an autoimmune disorder that affects the central nervous system (CNS) primarily hallmarked by neuroinflammation and demyelination. The activation of astrocytes exerts double-edged sword effects, which perform integral function in demyelination remyelination. In this research, we examined therapeutic effects Bu Shen Yi Sui capsule (BSYS), a traditional Chinese medicine prescription, cuprizone- (CPZ-) triggered model MS (CPZ mice). This research...
The extent and severity of neuronal damage is different in ischemia with reperfusion compared to no reperfusion. To investigate the role glutamate cerebral ischemia-reperfusion injury, vivo microdialysis was performed examine dynamic profile hippocampus a transient (30 min) or permanent middle artery occlusion (MCAo) Wistar rats. extracellular concentration cornu ammonis (CA)1 sector ipsilateral showed significant but elevation for both groups immediately following ischemic insult. initial...
Abstract The aim of this work is to investigate and analyze the main factors that influence quality life (QOL) multiple sclerosis (MS) patients. QOL (Multiple Sclerosis Impact Scale), disability (Expanded Disability Status fatigue (Modified Fatigue Scale) depression (Beck Depression Inventory) were assessed in 100 MS Correlation analysis shows positively correlated with status, depression, i.e. more severe disability, worse QOL. Multiple linear regression indicated Expanded Scale grade have...
Abstract Background Multiple sclerosis (MS) as an autoimmune disorder is a common disease occurring in central nervous system (CNS) and the remyelination plays pivotal role alleviating neurological impairment MS. Catalpol, effective component extracted from Chinese herb Radix Rehmanniae , which has been proved protective cerebral diseases. Methods To determine effects mechanisms of Catalpol on MS, mice with experimental encephalomyelitis (EAE) were induced by myelin oligodendrocyte...
Temporomandibular disorders are a common cause of chronic pain in the orofacial region and have complex multi-factorial pathophysiology. Mechanical loading or inflammatory conditions been shown to decrease oxygen tension within joint cartilage activate hypoxia-inducible factor (HIF) pathway, which turn aggravates pathological processes underlying temporomandibular (TMJ) disorders. We previously showed that low-intensity pulsed ultrasound (LIPUS) treatment effectively repairs TMJ injury...
Graphical Abstract Our results show that fingolimod is a potential therapeutic approach to prevent EAE-induced visual impairment. Moreover, we the observed neuro-ophthalmological protective effects of were dependent on hampering hyper-gliosis in retina and optic nerve.
Background: A prominent pathological feature of neuromyelitis optica spectrum disorders (NMOSD) is markedly greater eosinophilic infiltration than that seen in other demyelinating diseases, like multiple sclerosis (MS). Eosinophils express the chemokine receptor CCR3, which activated by eotaxins (CCL11/eotaxin-1, CCL24/eotaxin-2, CCL26/eotaxin-3) and CCL13 (monocyte chemoattractant protein-4). Moreover, part set activates CCR2. The present study aimed to evaluate plasma levels (CCL11, CCL24,...
Axonal damage is recognized as an important pathological feature in the chronic progressive neurological disorder multiple sclerosis (MS). Promoting axonal regeneration a critical strategy for treatment of MS. Our clinical and experimental studies have shown that Bu Shen Yi Sui formula (BSYS) promotes MS autoimmune encephalomyelitis (EAE), animal model MS, but exact mechanism has not been thoroughly elucidated to date. In this study, we investigated effects BSYS its two decomposed...
The endogenous neurotransmitter, noradrenaline, exerts anti-inflammatory and neuroprotective effects in vivo vitro. Reduced noradrenaline levels results increased inflammation neuronal damage. primary source of the central nervous system is tyrosine hydroxylase (TH)‑positive neurons, located locus coeruleus (LC). TH rate‑limiting enzyme for synthesis; therefore, regulation protein expression intrinsic activity represents means controlling synthesis noradrenaline. Catalpol an iridoid...
Axon growth inhibitory factors NogoA/Nogo receptor (NgR) and its signaling pathways RhoA/Rho kinase (ROCK) play a critical role in the repair of nerve damage multiple sclerosis (MS). Bu Shen Yi Sui Capsule (BSYSC) is an effective Chinese formula utilized to treat MS clinical setting noted for potent neuroprotective effects. In this study, we focus on effects BSYSC promoting underlying mechanisms mice with experimental autoimmune encephalomyelitis (EAE), animal model MS.The EAE mouse was...
Object. A novel postsynaptic antagonist of N-methyl- d -aspartate (NMDA) receptors, CP-101,606-27 may attenuate the effects focal ischemia. In current experiments, authors investigated its neuroprotective effect alone and in combination with recombinant tissue plasminogen activator (rt-PA) thromboembolic cerebral ischemia rats. Methods. Forty-eight male Wistar rats underwent embolization right middle artery to produce After random division into six groups (eight each group), animals...
A preliminary clinical study by our group demonstrated Bushen Yisui Capsule (formerly called Erhuang Formula) in combination with conventional therapy is an effective prescription for the treatment of multiple sclerosis. However, its effect on axonal injury during early sclerosis remains unclear. In this study, a MOG35-55-immunized C57BL/6 mouse model experimental autoimmune encephalomyelitis was intragastrically administered Capsule. The results showed that effectively improved symptoms and...
To investigate the association of pain with plasma C5a levels and other related inflammatory cytokines in neuromyelitis optica spectrum disorders (NMOSD) patients during remission.NMOSD (n = 87) healthy controls (HC; n 44) were consecutively recruited between January 2017 April 2018. Plasma complement 5 (C5), C5a, interleukin (IL)-6, tumor necrosis factor (TNF)-α, IL-1β detected. Visual Analogue Scale (VAS), ID scale, 24-item Hamilton Depression (HAMD), Multiple Sclerosis Impact (MSIS-29),...
The homeostatic balance between production and elimination of CD4+ T cells in peripheral blood plays an important role patients with neuromyelitis optica (NMO). objective the present study was to evaluate anti-apoptosis genes Bcl-2 its promoter signal (nuclear factor kappa-light-chain-enhancer activated B cells, NFκB) cells. Healthy subjects (HS, n = 25) multiple sclerosis (MS) (n NMO 30) remission were consecutively enrolled this prospective May December 2015. isolated using magnetic beads...