A5056916842- Autoimmune and Inflammatory Disorders Research
- Parasites and Host Interactions
- Parasite Biology and Host Interactions
- Kawasaki Disease and Coronary Complications
- Neuroinflammation and Neurodegeneration Mechanisms
- Cytomegalovirus and herpesvirus research
- Adolescent and Pediatric Healthcare
- Cancer, Hypoxia, and Metabolism
- Helminth infection and control
- Viral gastroenteritis research and epidemiology
- Seaweed-derived Bioactive Compounds
- Tuberculosis Research and Epidemiology
- Escherichia coli research studies
- Pharmacological Effects of Natural Compounds
- Multiple Sclerosis Research Studies
- Pulmonary Hypertension Research and Treatments
- Epigenetics and DNA Methylation
- Respiratory viral infections research
- Parasitic infections in humans and animals
- Intensive Care Unit Cognitive Disorders
- Animal Disease Management and Epidemiology
- Neurogenesis and neuroplasticity mechanisms
- Bacteriophages and microbial interactions
- Mast cells and histamine
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Shanxi Normal University
2025
Harbin University of Commerce
2015-2024
First Affiliated Hospital of Zhengzhou University
2018-2024
Shanghai Sixth People's Hospital
2024
Shanghai Jiao Tong University
2024
Shanghai Skin Disease Hospital
2024
Tongji University
2024
Shanghai East Hospital
2024
University of Kansas
2017-2023
Children's Hospital of Fudan University
2023
As an acute febrile and inflammatory disease, Kawasaki disease (KD) could develop shock syndrome (KDSS) sometimes. However its pathogenesis was still not well known. This study to learn more about the clinical features evaluate role of cytokines in KDSS.We collected laboratory data retrospectively for all patients with KDSS(KDSS, n = 27)who were hospitalized at our hospital from Jan 2014 Oct 2017. For patient KDSS, we randomly identified 43 KD as control subjects (KD, 43). Clinical features,...
Abstract Non-small-cell lung cancer (NSCLC), the most common type of accounting for 85% cases, is often diagnosed at advanced stages owing to lack efficient early diagnostic tools. 5-Hydroxymethylcytosine (5hmC) signatures in circulating cell-free DNA (cfDNA) that carries cancer-specific epigenetic patterns may represent valuable biomarkers discriminating tumor and healthy individuals, thus could be potentially useful NSCLC diagnosis. Here, we employed a sensitive reliable method map...
Abstract This scoping review analyzes the research gaps of three diseases: schistosomiasis japonica, malaria and echinococcosis. Based on available data in P.R. China, we highlight between control capacity prevalence levels, diagnostic/drug development population need for treatment at different stages national programme. After reviewing literature from 848 original studies consultations with experts field, were identified as follows. Firstly, include (i) deficiency active testing public...
Abstract Aims Postoperative cognitive dysfunction (POCD) is prevalent among the elderly, characterized primarily by decline after surgery. This study aims to explore how extracellular vesicles (EVs) derived from BV2 microglial cells, with and without C‐C chemokine receptor type 5 (CCR5), affect neuroinflammation, neuronal integrity, function in a POCD mouse model. Methods We collected EVs LPS‐stimulated cells expressing CCR5 (EVs M1 ) knockdown M1‐CCR5 ). These were administered POCD‐induced...
Summary Background and objective The mechanisms of Mycoplasma pneumoniae induced lung inflammation are not clearly understood yet. This study investigated whether activated T cells in the airway contributed to pulmonary patients with severe pneumonia (MPP). Methods BALF were collected all 45 MPP (MPP, n = 45), including mild (Mild, 20) (Severe, 25) group. 20 25 cases at recovery stage (Rec‐severe, again. control group consisted foreign body aspiration (Con., 20). CD3+ cells, CD69+, HLA‐DR+,...
Background: Esophageal squamous cell carcinoma (ESCC) is one of the most fatal diseases worldwide.Because early diagnosis difficult, ESCC mostly diagnosed at an advanced stage, leading to a poor overall prognosis.The purpose this study was explore differences between plasma metabolic profiles in patients and healthy controls establish diagnostic model ESCC.Methods: In study, cohort 310 subjects, containing 140 170 (HC), recruited.Participants were randomly separated into training set (80...
Over the past few decades, China has experienced significant demographic and epidemiological changes. The sharp decline in fertility mortality rates accelerated population aging, contributing to an increase prevalence of chronic diseases. nutritional condition during early life is associated with onset illnesses later adulthood. However, it remains unclear whether this association also increases risk multimorbidity This study aimed systematically evaluate between early-life famine exposure...
Background: A delay in the diagnosis of acute ischemic stroke (AIS) reduces eligibility and outcome patients for thrombolytic therapy. Therefore, early treatment AIS are crucial. The present study evaluated sensitivity accuracy serum extracellular vesicle (EV)-derived miR-124-3p prediction AIS. Methods: An miRNA expression profile was downloaded from Gene Expression Omnibus (GEO) database analyzed by R software. EVs were harvested using a total exosome isolation kit characterized Western...
Cytomegalovirus (CMV) infection enhances expression of several cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), granulocyte macrophage colony-stimulating factor (GM-CSF), and IL-8, to the benefit virus replication dissemination. However, stimulus for certain cytokine production remains unclear. CMV encodes a series proteins that alter and/or mimic functions leukocyte migration, activation, responses. Our study revealed human (HCMV)-encoded UL128 protein, which...
In this study, our purpose is to discover the correlation between polysaccharides sulfated structure and anti-tumor activity. Sulfated polysaccharide from Sargassum fusiforme were synthesized with chlorosulfonic acid pyridine method. The inhibitory effect of application MTT assay before after chemical modification on proliferation hepatocellular carcinoma HepG-2 cells in vitro studied. sargassum DS 0.803. modified has certain cells, its inhibition growth improved compared original SFPs....
T helper (Th) 17 and regulatory (Treg) cells play a critical role in the pathogenesis of multiple sclerosis (MS) disease. Bu Shen Yi Sui Capsule (BSYSC), traditional Chinese medicine formula, has been used clinically for treatment MS patients China. To evaluate neuroprotective effects underlying mechanisms BSYSC on MS, experimental autoimmune encephalomyelitis (EAE) model C57BL/6 mice was induced with myelin oligodendrocyte glycoprotein (MOG) 35–55. Th17 Treg related cytokines were detected...
This study aims to investigate the role of microRNA-145 (miR-145) in protection against myocardial ischemia/reperfusion (I/R) injury mice by regulating expression granzyme K (GZMK) with treatment sevoflurane. The model I/R was established left coronary artery ligation. miR-145 and GZMK tissues detected Reverse transcription quantitative polymerase chain reaction western blot analysis. changes cardiac function hemodynamics, pathological tissues, ultrastructure cardiomyocytes, infarction area,...
Infections caused by the opportunistic pathogen Pseudomonas aeruginosa can be difficult to treat due innate and acquired antibiotic resistance this is exacerbated emergence of multi-drug resistant strains. Unfortunately, no licensed vaccine yet exists prevent infections. Here we describe a novel subunit that targets P. type III secretion system (T3SS). This based on antigen PaF (Pa Fusion), fusion T3SS needle tip protein, PcrV, first two translocator proteins, PopB. Additionally, made...
Lung cancer is a fatal complication of idiopathic pulmonary fibrosis (IPF) with poor prognosis. Current treatments are insufficient in improving the prognosis lung patients comorbid (IPF-LC). Senescent fibroblasts, as stromal cells tumor microenvironment, influence progression via exosomes. With evidence that fibroblast senescence an important mechanism IPF, we investigated impact senescent IPF (diseased human DHLF)-derived exosomes on non-small cell (NSCLC). We found DHLF expressed...
Abstract Background Hookworm is still one of the three main soil-transmitted helminths prevalent in China, and 39 million cases infected with hookworm were estimated China 2006. Results The approach to control infections consists large-scale deworming, rebuilding sanitation systems rural areas health education. availability low-cost, safe single-dose albendazole make deworming programs possible China. Currently, sanitary latrines three-cells are recommended by government for helminths, since...
Transcriptome sequencing showing the potential mechanisms of Dunaliella salina in response to copper stress.