A5078839526- Immunotherapy and Immune Responses
- Signaling Pathways in Disease
- Circular RNAs in diseases
- Single-cell and spatial transcriptomics
- RNA Interference and Gene Delivery
- Mitochondrial Function and Pathology
- Viral Infections and Vectors
- Cardiac Ischemia and Reperfusion
- Mast cells and histamine
- Galectins and Cancer Biology
- Nerve injury and regeneration
- Biochemical effects in animals
- Hepatitis B Virus Studies
- Peptidase Inhibition and Analysis
- Traditional Chinese Medicine Analysis
- Neurogenetic and Muscular Disorders Research
- Cell Image Analysis Techniques
- Sirtuins and Resveratrol in Medicine
- Mathematical Biology Tumor Growth
- Corneal Surgery and Treatments
- Advanced Drug Delivery Systems
- Neurological Disease Mechanisms and Treatments
- Hereditary Neurological Disorders
- Anesthesia and Neurotoxicity Research
- Food Allergy and Anaphylaxis Research
Capital Medical University
2025
Children's Hospital of Fudan University
2021-2023
Fudan University
2019-2022
Jilin University
2008-2021
Shanghai Medical College of Fudan University
2019
National Cheng Kung University
2010-2014
Jilin University of Chemical Technology
2008
Effective treatments for neurodegenerative diseases need to be developed.MiR132 is abundantly expressed in the brain, and it modulates neuron morphology plays a key role maintaining survival. Regulating miR132 can effectively improve symptoms of Alzheimer's disease. It also reduce cell death after cerebral hemorrhage, microenvironment hematoma lesions provide certain protective effect from brain damage ischemia. MiR132 has great potential treatment ischemia To prevent degradation blood, we...
Medulloblastoma (MB), a heterogeneous pediatric brain tumor, poses challenges in the treatment of tumor recurrence and dissemination. To characterize cellular diversity genetic features, we comprehensively analyzed single-cell/nucleus RNA sequencing (sc/snRNA-seq), single-nucleus assay for transposase-accessible chromatin (snATAC-seq), spatial transcriptomics profiles identified distinct populations SHH (sonic hedgehog) Group_3 subgroups, with varying proportions local or Local showed higher...
Despite numerous studies on medulloblastoma (MB) cell heterogeneity, the spatial characteristics of cellular states remain unclear. We analyze single-nucleus and transcriptomes chromatin accessibility from human MB spanning four subgroups, to identify malignant populations describe evolutionary trajectories. The CNVs patterns niches were analyzed investigate interactions. Three main identified, including progenitor-like, cycling differentiated populations. Gene signatures strongly correlate...
Because the role of viral B2 protein in pathogenesis nervous necrosis virus infection remains unknown, aim present study was to determine effects on hydrogen peroxide (H2O2)-mediated cell death via mitochondrial targeting. Using a deletion mutant, targeting signal sequence ((41)RTFVISAHAA(50)) correlated with free radical production and fish cells, embryonic zebrafish, human cancer cells. After treatment grouper fin cells (GF-1) overexpressing anti-oxidant drug, N-acetylcysteine (NAC),...
Co-delivery nanoparticles with characteristics of intracellular precision release drug have been generally accepted as an effective therapeutic strategy for eye diseases. In this study, we designed a new co-delivery system (miRNA/NP-BRZ) lasting approach to prevent the neuro-destructive after long-term treatment glaucoma. Neuroprotective and intraocular pressure (IOP) response were assessed in vivo vitro models At meaning time, describe preparation miRNA/NP-BRZ, characteristics, tracing,...
Background: A delay in the diagnosis of acute ischemic stroke (AIS) reduces eligibility and outcome patients for thrombolytic therapy. Therefore, early treatment AIS are crucial. The present study evaluated sensitivity accuracy serum extracellular vesicle (EV)-derived miR-124-3p prediction AIS. Methods: An miRNA expression profile was downloaded from Gene Expression Omnibus (GEO) database analyzed by R software. EVs were harvested using a total exosome isolation kit characterized Western...
To prepare a binary formulation delivering miRNA-146 and evaluate nucleic acid nasal delivery system by investigating its pharmacodynamic effects in allergic rhinitis. The gel/NPs/miR-146a thermosensitive situ chitosan hydrogel carrying was prepared evaluated for characteristics, including temperature sensitivity, gel strength, mucosal adhesion drug release profile. After administration of the to ovalbumin-sensitized rats, treatment rhinitis verified assessing symptoms, hematology,...
The betanodavirus non-structural protein B2 is a newly discovered necrotic death factor with still unknown role in regulation of mitochondrial function. In the present study, we examined B2-mediated inhibition complex II activity, which results ATP depletion and thereby bioenergetic crisis vitro vivo. Expression was detected early at 24 h postinfection red-spotted grouper nervous necrosis virus cytoplasm. Later found mitochondria using enhanced yellow fluorescent (EYFP) immuno-EM analysis....
This study aims to investigate the role of microRNA-145 (miR-145) in protection against myocardial ischemia/reperfusion (I/R) injury mice by regulating expression granzyme K (GZMK) with treatment sevoflurane. The model I/R was established left coronary artery ligation. miR-145 and GZMK tissues detected Reverse transcription quantitative polymerase chain reaction western blot analysis. changes cardiac function hemodynamics, pathological tissues, ultrastructure cardiomyocytes, infarction area,...
Insulin resistance is one major features of type 2 diabetes mellitus (T2DM). Deuterohemin-βAla-His-Thr-Val-Glu-Lys (DhHP-6), a novel microperoxidase mimetic designed and synthesized based on 11 (MP-11), can scavenge reactive oxygen species (ROS) in vivo. In our previous studies, we showed that oral DhHP-6 could reduce blood glucose improve insulin resistance. To investigate the mechanisms how ameliorates oxidative stress resistance, established T2DM mouse models glucosamine-induced HepG2...
Abstract Background Kinase D‐interacting substrate of 220 kDa (KIDINS220) is a multifunctional scaffolding protein essential for neuronal development. It has been implicated in neurological diseases with either autosomal dominant (AD) or recessive (AR) inheritance patterns. The molecular mechanisms underlying the AR/AD dual nature KIDINS220 remain elusive, posing challenges to genetic interpretation and clinical interventions. Moreover, increased exhibited neurotoxicity, but its role...
Type 2 diabetes mellitus (T2DM) is associated with pancreatic β-cell dysfunction which can be induced by oxidative stress. Deuterohemin-βAla-His-Thr-Val-Glu-Lys (DhHP-6) a microperoxidase mimetic that scavenge reactive oxygen species (ROS) in vivo. In our previous studies, we demonstrated an increased stability of linear peptides upon their covalent attachment to porphyrins. this study, assessed the utility DhHP-6 as oral anti-diabetic drug vitro and showed high resistance proteolytic...
Chronic hepatitis B virus (HBV) infection remains a global public health problem. HBV-encoded X protein (HBx) is multifunctional regulator that required to initiate and maintain productive HBV infection, involved in HBV-related hepatocellular carcinoma (HCC). Inhibitors interfere with the functions of HBx could be useful not only for inhibition replication but also prevention or treatment HCC. To screen molecules target on large scale technical challenge due lack sensitive high-throughput...
Background Perioperative hypersensitivity reaction (HR) is an IgE-FcϵRI-mediated with degranulation and activation of mast cells basophils. Several studies have focused on assessing the basophils to diagnose predict prognosis drug induced HR. However, it challenging isolate sufficiently pure from human sources investigate. Effective biomarkers assess in vivo could potentially high diagnostic prognostic values. In present study, we investigated EVs pelleted serum patients succinylated gelatin...
Abstract Background Cerebral palsy (CP), the most common physical disability of childhood, is a nonprogressive movement disorder syndrome. Eighty percent cases are considered idiopathic without clear cause. Evidence has shown that cytokine abnormalities widely thought to contribute CP. Methods An association between IL2RA (rs12244380, rs2025345, rs12722561, rs4749926, rs2104286 and rs706778) CP was investigated using case-control method based on 782 778 controls. The allele, genotype...