A5101704740- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Bone health and treatments
- Single-cell and spatial transcriptomics
- Receptor Mechanisms and Signaling
- Renin-Angiotensin System Studies
- Childhood Cancer Survivors' Quality of Life
- Synthesis of heterocyclic compounds
- Synthesis and Reactions of Organic Compounds
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Epigenetics and DNA Methylation
- Biomedical Ethics and Regulation
- Cardiac electrophysiology and arrhythmias
- Scoliosis diagnosis and treatment
- CAR-T cell therapy research
- Amino Acid Enzymes and Metabolism
- Mathematical Biology Tumor Growth
- Immunotherapy and Immune Responses
- Spinal Fractures and Fixation Techniques
- Phagocytosis and Immune Regulation
- Glioma Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Extracellular vesicles in disease
- Genomics and Rare Diseases
- Immune Cell Function and Interaction
Baylor College of Medicine
2024-2025
Texas Children's Hospital
2024-2025
Hospital for Sick Children
2020-2025
SickKids Foundation
2025
Children's Cancer Center
2024-2025
West Virginia University
2001
Summary: We are building the world's first Virtual Child–a computer model of normal and cancerous human development at level each individual cell. The Child will “develop cancer” that we subject to unlimited virtual clinical trials pinpoint, predict, prioritize potential new treatments, bringing forward day when no child dies cancer, giving one opportunity lead a full healthy life.
Despite numerous studies on medulloblastoma (MB) cell heterogeneity, the spatial characteristics of cellular states remain unclear. We analyze single-nucleus and transcriptomes chromatin accessibility from human MB spanning four subgroups, to identify malignant populations describe evolutionary trajectories. The CNVs patterns niches were analyzed investigate interactions. Three main identified, including progenitor-like, cycling differentiated populations. Gene signatures strongly correlate...
A series of primate renin inhibitors containing difluorocarbinol and difluoroketone groups at the P1-P1' position have been synthesized studied both in vitro vivo. In vitro, compounds were evaluated as monkey closely related aspartic proteinase, cathepsin D (bovine), a measure enzyme selectivity. Interestingly, derivatives showed greatly reduced selectivity compared with corresponding alcohols. However, could be enhanced by judicious choice other substituents. Sites influencing selectivity,...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTRenin inhibitors containing .alpha.-heteroatom amino acids as P2 residuesJoseph T. Repine, James S. Kaltenbronn, Annette M. Doherty, Hamby, Richard J. Himmelsbach, Brian E. Kornberg, Michael D. Taylor, ELizabeth A. Lunney, Christine Humblet, and Cite this: Med. Chem. 1992, 35, 6, 1032–1042Publication Date (Print):March 1, 1992Publication History Published online1 May 2002Published inissue 1 March...
Abstract The reactivation of neurodevelopmental programs in cancer highlights parallel biological processes that occur both normal development and brain tumors. Achieving a deeper understanding how dysregulated developmental factors play role the progression tumors is therefore crucial for identifying potential targets therapeutic interventions. Single-cell RNA sequencing (scRNA-Seq) provides an opportunity to understand are reinitiated at single-cell resolution. Here, we introduce COORS...
Here, we present a protocol for preclinical evaluation of locoregionally delivered CAR T cells in patient-derived xenograft models primary, metastatic, and recurrent brain tumors. We provide instructions isolating peripheral blood mononuclear (PBMCs), producing conjunction with locoregional delivery, trial design analysis involving cells. Additionally, describe comprehensive readouts guidelines critical endpoint sample collections. In line clinical procedures, our broadens available...
Abstract Purpose: An expected outcome following germline genome sequencing in oncology is the discovery of ‘secondary findings’ (SFs). SFs comprise pathogenic(P)/likely P (LP) variants cancer genes not typically associated with presenting cancer, addition to uncertain significance (VUS) patient’s cancer. Due rarity childhood cancers and a dearth studies analyzing SFs, many pediatric are categorized as VUS without clinical interpretation. Interpreting poses significant challenges: VUSs other...
Abstract ChemInform is a weekly Abstracting Service, delivering concise information at glance that was extracted from about 100 leading journals. To access of an article which published elsewhere, please select “Full Text” option. The original trackable via the “References”
<p>Differential Expression in Isogenic Lines</p>
<p>Supplementary Information</p>
<p>Pathway Enrichment Analysis</p>
<p>Sample Characteristics and Quality Control</p>
<div>Abstract<p>Glycine 34-to-tryptophan (G34W) substitutions in H3.3 arise approximately 90% of giant cell tumor bone (GCT). Here, we show G34W is necessary for formation. By profiling the epigenome, transcriptome, and secreted proteome patient samples tumor-derived cells CRISPR–Cas9-edited G34W, that H3.3K36me3 loss on mutant alters deposition repressive H3K27me3 mark from intergenic to genic regions, beyond areas deposition. This promotes redistribution other chromatin marks...
Abstract Aus den 4‐Amino‐1‐methylpyrimidin‐6‐onen (I) entstehen die Halogenacetamido‐Verbindungen (II) und (III), aus denen das Iodid (IV) durch Austauschreaktion erhalten werden kann.