A5101984249- Rheumatoid Arthritis Research and Therapies
- Genetic and phenotypic traits in livestock
- Animal Nutrition and Physiology
- Musculoskeletal synovial abnormalities and treatments
- Genetic Mapping and Diversity in Plants and Animals
- Glioma Diagnosis and Treatment
- Bone and Joint Diseases
- Radiomics and Machine Learning in Medical Imaging
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Medical Imaging and Pathology Studies
- Systemic Lupus Erythematosus Research
- Lung Cancer Diagnosis and Treatment
- Multiple Sclerosis Research Studies
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Osteoarthritis Treatment and Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Infectious Diseases and Tuberculosis
- Peripheral Neuropathies and Disorders
- Genetic factors in colorectal cancer
- Radiation Dose and Imaging
- Cytomegalovirus and herpesvirus research
- Spine and Intervertebral Disc Pathology
- Fetal and Pediatric Neurological Disorders
Chinese University of Hong Kong
2016-2025
Jiangsu Province Hospital
2022-2025
Nanjing Medical University
2022-2025
Prince of Wales Hospital
2016-2024
Chongqing Medical University
2011-2024
Children's Hospital of Chongqing Medical University
2011-2024
Xidian University
2023-2024
Chinese PLA General Hospital
2024
University of Hong Kong
2024
Suizhou Central Hospital
2024
Objective To compare the bone healing effects of denosumab and alendronate in female rheumatoid arthritis (RA) patients by high‐resolution peripheral quantitative computed tomography. Methods This is a post hoc analysis randomized controlled trial. Forty were 1:1 ratio to receive either subcutaneous (60 mg) once or oral (70 weekly for 6 months. The size individual erosions presence extent erosion‐associated sclerosis (marginal osteosclerosis) measured second metacarpal head nondominant hand...
Abstract Background The identification of markers and genes for growth traits may not only benefit marker assist selection /genomic but also provide important information understanding the genetic foundation in broilers. Results In current study, we estimated parameters eight broilers carried out genome-wide association studies these traits. A total 113 QTNs discovered by multiple methods together, some genes, including ACTA1 , IGF2BP1 TAPT1 LDB2 PRKCA TGFBR2 GLI3 SLC16A7, INHBA, BAMBI,...
Feed consumption represents a major cost in poultry production and improving feed efficiency is one of the important goals breeding strategies. The present study aimed to analyze relationship between relevant traits find proper selection method for by using Northeast Agricultural University High Low Fat broiler lines that were divergently selected abdominal fat content. A total 899 birds used measure intake (FI), weight (AFW), body traits. percentage (AFP), conversion ratio (FCR), residual...
Rapid growth is one of the most important economic traits in broiler breeding programs. Identifying markers and genes for may not only benefit marker-assisted selection (MAS)/genomic (GS) but also provide information understanding genetic architecture broilers. In present study, an F2 resource population derived from a cross between Baier yellow chicken (a Chinese local breed) was used body weights 1 to 12 weeks age [body weight (BW) 1-BW12)] were measured. A total 519 birds genome...
Abstract Objective Bone inflammation (osteitis) in early RA (ERA) manifests as bone marrow oedema (BME) and precedes the development of erosion. In this prospective, single-centre study, we developed an automated post-processing pipeline for quantifying severity wrist BME on T2-weighted fat-suppressed MRI. Methods A total 80 ERA patients [mean age 54 years (s.d. 12), 62 females] were enrolled at baseline 49 (40 females) after 1 year treatment. For segmentation, a framework based...
Purpose: To propose and evaluate an accelerated $T_{1\rho}$ quantification method that combines $T_{1\rho}$-weighted fast spin echo (FSE) images proton density (PD)-weighted anatomical FSE images, leveraging deep learning models for mapping. The goal is to reduce scan time facilitate integration into routine clinical workflows osteoarthritis (OA) assessment. Methods: This retrospective study utilized MRI data from 40 participants (30 OA patients 10 healthy volunteers). A volume of...
Abstract Objective To determine how inflammatory and structural parameters change long-term on standard treatment in rheumatoid arthritis patients which baseline parameter best predicts damage. Material methods Prospective study of early (ERA) (symptom duration ≤ 24 months) who underwent identical clinical, serological, radiographic, dynamic contrast-enhanced MRI the wrist assessments at baseline, year-1, year-8. MR images were analyzed semi-quantitatively (Rheumatoid Arthritis Magnetic...
The bones of chicken play an important role in supporting and protecting the body. growth development have a substantial influence on health production performance chickens. However, genetic architecture underlying bone traits is not well understood. objectives this study are to dissect basis chickens identify valuable genes markers for breeding. We performed combination genome-wide association (GWAS) selection signature analysis (fixation index values nucleotide diversity ratios) F2...
In clinical practice, a number of delayed diagnoses localized pneumonic-type lung adenocarcinoma (L-PLADC) mimicking pneumonia have been identified due to the lack knowledge regarding radiological findings associated with this condition. Here, we defined L-PLADC as special type that presents focal consolidation involving < 50% area lobe and aimed investigate differential imaging features between pulmonary inflammatory lesion (L-PIL).The data 120 patients 125 L-PIL who underwent...
BackgroundThe long-term prognosis for patients with osteosarcoma (OS) metastasis remains unfavourable, highlighting the urgent need research that explores potential biomarkers using innovative methodologies.MethodsThis study explored OS by analysing data from Cancer Genome Atlas Program (TCGA) and Gene Expression Omnibus (GEO) databases. The synthetic minority oversampling technique (SMOTE) was employed to tackle class imbalances, while genes were selected four feature selection algorithms...
Background: Considerable variability exists in normal developmental lumbar spinal canal size. This impacts the likelihood of neural compromise. Spinal development is complete by 17 years. As diseases incurred thereafter do not knowingly affect size canal, it reasonable to use a selected population undergoing abdominopelvic computed tomography (CT) examination determine Methods: Study approval was granted Clinical Research Ethics Committee. Between Feb 2014 and Jan 2015, mid-vertebral...
The glioma immune microenvironment (GIM), consisting of cells, stromal and accelerates the initiation, development, evasion, chemoresistance, radioresistance glioblastoma (GBM), whereas immunosuppressive mechanisms GBM have not been thoroughly elucidated to date. data downloaded from Cancer Genome Atlas (TCGA) Chinese Glioma (CGGA) databases were used evaluate composition tumor-infiltrating cells (TICs) by CIBERSORT algorithm. RNA-seq datasets TCGA CGGA analyze relationship between scores...
Improving the production of broiler chicken meat has been a goal breeding programs worldwide for many years. However, genetic architectures skeletal muscle traits in chickens have not yet fully elucidated. In present study, total 519 F 2 birds, derived from cross Arbor Acres and Baier layer, were re-sequenced (26 0 individuals at 10-fold depth; 3-fold depth) coupling genome-wide association study (GWAS) selection signatures ( ST (fixation index) θ π (nucleotide diversity)) was carried out to...
The growth and development of chicken bones have an enormous impact on the health production performance chickens. However, pattern genetic regulation skeleton are poorly understood. This study aimed to evaluate metatarsal bone patterns in chickens via nonlinear models, identify determinants traits using a genome-wide association (GWAS) based curve parameters. Data length (MeL) circumference (MeC) were obtained from 471 F2 (generated by crossing broiler sires, derived line selected for high...
To compare micro RNA (miRNA) expression: (a) between healthy individuals and early rheumatoid arthritis (ERA) patients with without erosion on high-resolution peripheral quantitative computed tomography (HR-pQCT) at baseline; (b) to explore whether these miRNAs could inform a signature predictive of progression despite treatment conventional synthetic disease-modifying antirheumatic drugs (csDMARDs).The second metacarpophalangeal head (MCP2) was scanned by HR-pQCT baseline 1 year in 117 ERA...
Chicken internal organs are indispensable parts of the body, but their genetic architectures have not been commonly understood. Herein, we estimated parameters for heart weight (HW), liver (LW), spleen (SpW), testis (TW), glandular stomach (GSW), muscular (MSW) and identified single nucleotide polymorphisms (SNPs) potential candidate genes associated with organ weights in an F2 population constructed by crossing broiler cocks derived from Arbor Acres high abdominal fat content Baier layer...
Magnetic resonance imaging (MRI) allows accurate determination of soft tissue and bone inflammation in rheumatoid arthritis. Inflammation can be measured semi-quantitatively using the well-established RA-MRI scoring system (RAMRIS), but its application is time consuming routine clinical practice. To fully realize an automated quantitation for use, automatic segmentation wrist bones on MR needed. Most previous studies extracted T1-weighted (T1W) images, then used registration to segment T2W...
Objective: To analyze the positive and recurrence rates of different autoantibody-associated demyelination disorders in children Southwest China, describe clinical, radiological, prognostic features myelin oligodendrocyte glycoprotein antibody (MOG-ab) aquaporin-4 (AQP4-ab) associated disease. This study also summarizes steroid maintenance therapy approaches for MOG-ab-positive children. Methods: A total 160 presenting with acquired demyelinating syndromes (ADS) between January 2016 December...
Based on the "seed and soil" theory proposed by previous studies, we aimed to develop validate a combined model of machine learning for predicting lymph node metastasis (LNM) in patients with peripheral lung adenocarcinoma (PLADC).Radiomics models were developed primary cohort 390 (training cohort) pathologically confirmed PLADC from January 2016 August 2018. The divided into LNM (-) (+) groups. Thereafter, subdivided according TNM stages N0, N1, N2, N3. Radiomic features unenhanced computed...
This study aimed to compare the clinical, radiological, therapeutic, and prognostic differences between pediatric patients showing acute disseminated encephalomyelitis (ADEM) with without myelin oligodendrocyte glycoprotein (MOG) antibodies.We retrospectively collected all available data of children diagnosed ADEM tested for serum MOG antibodies at Children's Hospital Chongqing Medical University from January 2017 May 2021.A total 62 were included in our cohort, which 35 MOG-seropositive 27...