A5078526615- Nerve injury and regeneration
- Circular RNAs in diseases
- Neurogenesis and neuroplasticity mechanisms
- Advanced MRI Techniques and Applications
- Advanced Neuroimaging Techniques and Applications
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Glioma Diagnosis and Treatment
- Functional Brain Connectivity Studies
- Peripheral Neuropathies and Disorders
- RNA Research and Splicing
- Extracellular vesicles in disease
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- Silk-based biomaterials and applications
- Immune Cell Function and Interaction
- Neuropeptides and Animal Physiology
Nanjing Medical University
2023-2025
Jiangsu Province Hospital
2023-2025
Nantong University
2018-2021
Abstract Long noncoding RNAs (lncRNAs) are involved in glioma initiation and progression. Glioma stem cells (GSCs) essential for tumor initiation, maintenance, therapeutic resistance. However, the biological functions underlying mechanisms of lncRNAs GSCs remain poorly understood. Here, we identified that LINC00839 was overexpressed GSCs. A high level associated with GBM progression radiation METTL3-mediated m6A modification on enhanced its expression a YTHDF2-dependent manner....
Cytokines are essential cellular modulators of various physiological and pathological activities, including peripheral nerve repair regeneration. However, the molecular changes these mediators after injury still unclear. This study aimed to identify cytokines critical for regenerative process injured nerves. The sequencing data stumps dorsal root ganglia (DRGs) Sprague-Dawley (SD) rats subjected sciatic (SN) crush were analyzed determine expression patterns genes coding cytokines. PCR was...
MicroRNAs (miRNAs) can regulate the modulation of phenotype Schwann cells. Numerous novel miRNAs have been discovered and identified in rat sciatic nerve segments, including miR-3099. In current study, miR-3099 expression levels following peripheral injury were measured proximal stumps nerves after surgical crush. Real-time reverse transcription-polymerase chain reaction was used to determine crushed segment at 0, 1, 4, 7, 14 days post injury, which consistent with Solexa sequencing...
MicroRNAs refer to a class of endogenous, short non-coding RNAs that mediate numerous biological functions. regulate various physiological and pathological activities peripheral nerves, including nerve repair regeneration. Previously, using rat sciatic injury model, we identified many functionally annotated novel microRNAs, miR-sc14. Here, used real-time reverse transcription-polymerase chain reaction examine miR-sc14 expression in stumps. Our results show is noticeably altered following...
Abstract Objective The structural alteration that occurs within the salience network (SN) in patients with insular glioma is unclear. Therefore, we aimed to investigate changes topological and brain structure alterations SN glioma. Methods We enrolled 46 left glioma, 39 right 21 demographically matched healthy controls (HCs). compared network, gray matter (GM) volume, fractional anisotropy (FA) between HCs after controlling for effects of age gender. Results Patients showed decline mainly...
Abstract Background Patients with insulo-Sylvian gliomas continue to present severe morbidity in cognitive functions primarily due neurosurgeons’ lack of familiarity non-traditional brain networks. We sought identify the frequency invasion and proximity portions these Methods retrospectively analyzed data from 45 patients undergoing glioma surgery centered insular lobe. Tumors were categorized based on their invasiveness networks traditionally eloquent structures. Diffusion tensor imaging...
Abstract Background: Cytokines are essential cellular modulators of a variety physiological and pathological activities, including peripheral nerve repair regeneration. However, the molecular changes these mediators after injury not well clarified. The study is aimed to discover critical cytokines for regenerative process injured nerves. Methods: sequencing data stumps dorsal root ganglia (DRGs) Sprague-Dawley (SD) rats subjected sciatic (SN) crush were analyzed determine expression patterns...