A5083708010- Nerve injury and regeneration
- Wound Healing and Treatments
- Neurogenesis and neuroplasticity mechanisms
- Osteoarthritis Treatment and Mechanisms
- Circular RNAs in diseases
- Spine and Intervertebral Disc Pathology
- Axon Guidance and Neuronal Signaling
- Mercury impact and mitigation studies
- MicroRNA in disease regulation
- Signaling Pathways in Disease
- Gas Sensing Nanomaterials and Sensors
- Advanced Photocatalysis Techniques
- Cancer-related molecular mechanisms research
- Crystallization and Solubility Studies
- Gut microbiota and health
- X-ray Diffraction in Crystallography
- Coal and Its By-products
- Pain Mechanisms and Treatments
- Neuropeptides and Animal Physiology
- Healthcare and Venom Research
- Chemical Synthesis and Characterization
- Arsenic contamination and mitigation
- Thermal Regulation in Medicine
- Developmental Biology and Gene Regulation
- Neurological Disease Mechanisms and Treatments
Hunan University of Traditional Chinese Medicine
2024-2025
Nantong University
2018-2024
Sanming University
2023
Jilin Agricultural University
2022
Shanghai Customs College
2021-2022
Nanjing University of Chinese Medicine
2021
National Medical Products Administration
2021
Nantong Science and Technology Bureau
2018-2020
Yangzhou University
2019
Tau protein (encoded by the gene microtubule-associated tau, Mapt) is essential for assembly and stability of microtubule functional maintenance nervous system. highly abundant in neurons detectable astrocytes oligodendrocytes. However, whether tau present Schwann cells, unique glial cells peripheral system, unclear. Here, we investigated presence its coding mRNA, Mapt, cultured find that these cells. Gene silencing Mapt promoted cell proliferation inhibited migration differentiation. In...
Arsenic emissions from coal-fired power plants are highly toxic and volatile, posing a serious threat to human health the natural environment. The removal of arsenic flue gases has attracted widespread attention worldwide. Calcium-based sorbents can capture arsenic, thus solving environmental problem heavy metal pollution plants, but its sintering low efficiency impede application. Doping CaO with CeO2 is an efficient technique improve resistance facilitate efficiency. In this study,...
Macrophages are notable immune cells that recruited to the injury sites after peripheral nerve injury. Following injury, increasing numbers of macrophages engulf debris and promote regeneration. However, changes pro-inflammatory (M1) anti-inflammatory (M2) macrophages, two types with dissimilar biological functions, have not been discovered. In current study, expression profiles M1 M2 macrophage marker genes in sciatic stumps dorsal root ganglions (DRGs) rat were determined using RNA...
Arsenic emitted from coal-fired flue gas poses a threat to human health and the ecological environment due its high toxicity bioaccumulation. In this work, microscopic spherical α-Fe2O3 sorbent was prepared by one-step hydrothermal method effectively capture arsenic in gas. The effects of reaction temperature, sulfur dioxide (SO2), nitric oxide (NO), oxygen (O2), inlet concentration on adsorption performance were investigated. results showed that most suitable temperature 600 °C, As2O3(g)...
Schwann cells (SCs), fibroblasts and macrophages are the main in peripheral nerve stumps.
Peripheral nerve injury is a worldwide clinical issue that impacts patients' quality of life and causes huge society economic burden. Injured peripheral nerves are able to regenerate by themselves. However, for severe injury, the regenerative abilities very limited effects poor. A better understanding mechanisms following will benefit its treatment. In this study, we systematically explored dynamic changes mRNAs long non-coding RNAs (lncRNAs) in injured sciatic segments after crush,...
Tight junctions seal off physical barriers, regulate fluid and solute flow, protect the endoneurial microenvironment of peripheral nervous system. Physical barriers in system were disrupted after nerve injury. However, dynamic changes tight junction components injury have not been fully determined yet. In current study, by using previously obtained deep sequencing outcomes bioinformatic tools, we found that signaling pathway was activated The investigation temporal expression patterns...
MicroRNAs (miRNAs) can regulate the modulation of phenotype Schwann cells. Numerous novel miRNAs have been discovered and identified in rat sciatic nerve segments, including miR-3099. In current study, miR-3099 expression levels following peripheral injury were measured proximal stumps nerves after surgical crush. Real-time reverse transcription-polymerase chain reaction was used to determine crushed segment at 0, 1, 4, 7, 14 days post injury, which consistent with Solexa sequencing...
MicroRNAs refer to a class of endogenous, short non-coding RNAs that mediate numerous biological functions. regulate various physiological and pathological activities peripheral nerves, including nerve repair regeneration. Previously, using rat sciatic injury model, we identified many functionally annotated novel microRNAs, miR-sc14. Here, used real-time reverse transcription-polymerase chain reaction examine miR-sc14 expression in stumps. Our results show is noticeably altered following...
Neurotrophic factors, particularly nerve growth factor, enhance neuronal regeneration. However, the in vivo applications of factor are largely limited by its intrinsic disadvantages, such as short biological half-life, contribution to pain response, and inability cross blood-brain barrier. Considering that let-7 (human miRNA) targets regulates is a core regulator peripheral regeneration, we evaluated possibilities application repair. In this study, anti-let-7a was identified most suitable...
Cellular senescence and proliferation are essential for wound healing tissue remodeling. However, senescence-proliferation cell fate after peripheral nerve injury has not been clearly revealed. Here, post-injury gene expression patterns in rat sciatic stumps (SRP113121) L4-5 dorsal root ganglia (SRP200823) obtained from the National Center Biotechnology Information were analyzed to decipher cellular proliferation-associated genetic changes. We first constructed a crush model. Then,...
CD146 is cell adhesion molecule and implicated in a variety of physiological pathological processes. However, the involvement peripheral nerve regeneration has not been studied yet. Here, we examine spatial temporal expression pattern injured mouse sciatic via high-throughput data analysis, RT-PCR immunostaining. By microarray analysis validation, show that mRNA significantly up-regulated bridge distal stump following transection injury. single sequencing immunostaining, demonstrate Schwann...