Junxia Zhang
A5006307969- Glioma Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Immune cells in cancer
- Mathematical Biology Tumor Growth
- Phagocytosis and Immune Regulation
- Bioinformatics and Genomic Networks
- Cancer Immunotherapy and Biomarkers
- interferon and immune responses
- Epigenetics and DNA Methylation
- Chemokine receptors and signaling
- Ferroptosis and cancer prognosis
- Immunotherapy and Immune Responses
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Immune responses and vaccinations
- thermodynamics and calorimetric analyses
- Plant Virus Research Studies
- Poxvirus research and outbreaks
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Evolution and Genetic Dynamics
- Extracellular vesicles in disease
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
Nanjing Medical University
2022-2024
Jiangsu Province Hospital
2022-2024
Jiangsu Cancer Hospital
2022-2024
Tsinghua University
2024
Center for Life Sciences
2024
Abstract Isocitrate dehydrogenase (IDH) wild-type glioblastoma (GBM) has a dismal prognosis. A better understanding of tumor evolution holds the key to developing more effective treatment. Here we study GBM's natural evolutionary trajectory by using rare multifocal samples. We sequenced 61,062 single cells from eight IDH primary GBMs and defined signature (NES) tumor. show that NES significantly associates with activation transcription factors regulate brain development, including MYBL2...
Abstract Tumor-associated macrophages (TAM) play a crucial role in immunosuppression. However, how TAMs are transformed into immunosuppressive phenotypes and influence the tumor microenvironment (TME) is not fully understood. Here, we utilized single-cell RNA sequencing whole-exome data of glioblastoma (GBM) tissues identified subset dually expressing macrophage signatures, which were termed double-positive TAMs. Double-positive tended to be bone marrow–derived (BMDM) characterized by...
Abstract Extracellular matrix (ECM) remodeling has been implicated in the tumor malignant progression and immune escape glioblastoma (GBM). Runt-related transcription factor 1 (RUNX1) is a vital transcriptional for promoting tumorigenesis invasion mesenchymal subtype of GBM. But correlation between RUNX1 ECM genes expression regulatory mechanism on remain poorly understood to date. In this study, by using integral analysis chromatin immunoprecipitation-sequencing RNA sequencing, we reported...
Radiotherapy is a major component of standard-of-care treatment for gliomas, the most prevalent type brain tumor. However, resistance to radiotherapy remains concern. Identification mechanisms governing radioresistance in gliomas could reveal improved therapeutic strategies treating patients. Here, we report that mitochondrial metabolic pathways are suppressed radioresistant through integrated analyses transcriptomic data from glioma specimens and cell lines. Decreased expression peroxisome...
Abstract Purpose: The dynamic interplay between glioblastoma stem cells (GSC) and tumor-associated macrophages (TAM) sculpts the tumor immune microenvironment (TIME) promotes malignant progression of (GBM). However, mechanisms underlying this interaction are still incompletely understood. Here, we investigate role CXCL8 in maintenance mesenchymal state GSC populations reprogramming TIME to an immunosuppressive state. Experimental Design: We performed integrative multi-omics analyses RNA...
Glioblastoma, the most lethal primary brain tumor, harbors glioma stem cells (GSCs) that not only initiate and maintain malignant phenotypes but also enhance therapeutic resistance. Although frequently mutated in glioblastomas, function regulation of PTEN PTEN-intact GSCs are unknown. Here, we found directly interacted with MMS19 competitively disrupted MMS19-based cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) machinery differentiated cells. was specifically succinated at cysteine (C)...
Abstract Since the 2022 mpox outbreak, MPXV has caused ∼100,000 infected cases with ∼200 deaths across 117 countries. and was declared a public health emergency of international concern by WHO. The causative pathogen, monkeypox virus (MPXV), is zoonotic double-stranded DNA orthopoxvirus. To investigate structures replication mechanism MPXV, recombinant proteins vaccinia (VACV) particles have been studied cryo-EM, however, in situ structural insights into major assembly authentic are missing....
<p>Supplementary Figure S1-S7, and Supplementary table S1</p>
<p>Supplementary Figure S1-S7, and Supplementary table S1</p>
<div>Abstract<p>Purpose: The dynamic interplay between glioblastoma stem cells (GSC) and tumor-associated macrophages (TAM) sculpts the tumor immune microenvironment (TIME) promotes malignant progression of (GBM). However, mechanisms underlying this interaction are still incompletely understood. Here, we investigate role CXCL8 in maintenance mesenchymal state cell populations reprogramming TIME to an immunosuppressive state. Experimental Design: We performed integrative...
<p>Supplementary Figures and Figure legends</p>
<p>Supplementary Figures and Figure legends</p>