A5038509799- Cancer, Hypoxia, and Metabolism
- Glioma Diagnosis and Treatment
- Mitochondrial Function and Pathology
- Connexins and lens biology
- Peroxisome Proliferator-Activated Receptors
- Genomics, phytochemicals, and oxidative stress
- Adipose Tissue and Metabolism
- Mercury impact and mitigation studies
- Redox biology and oxidative stress
- Heat shock proteins research
- Pancreatic and Hepatic Oncology Research
- Electrocatalysts for Energy Conversion
- Heme Oxygenase-1 and Carbon Monoxide
- Computational Drug Discovery Methods
- Epigenetics and DNA Methylation
- Biochemical and Molecular Research
- Metalloenzymes and iron-sulfur proteins
- Cancer Cells and Metastasis
- Heavy Metal Exposure and Toxicity
- Autophagy in Disease and Therapy
- Glutathione Transferases and Polymorphisms
- Cancer therapeutics and mechanisms
- Lung Cancer Research Studies
- Selenium in Biological Systems
- Lung Cancer Treatments and Mutations
Nanjing Medical University
2022-2024
Jiangsu Province Hospital
2024
Jiangsu Cancer Hospital
2022-2024
Ministry of Education of the People's Republic of China
2017-2018
Fudan University
2016-2018
Radiotherapy is a major component of standard-of-care treatment for gliomas, the most prevalent type brain tumor. However, resistance to radiotherapy remains concern. Identification mechanisms governing radioresistance in gliomas could reveal improved therapeutic strategies treating patients. Here, we report that mitochondrial metabolic pathways are suppressed radioresistant through integrated analyses transcriptomic data from glioma specimens and cell lines. Decreased expression peroxisome...
Temozolomide (TMZ) is a standard treatment for glioblastoma (GBM) patients. However, TMZ has moderate therapeutic effects due to chemoresistance of GBM cells through less clarified mechanisms. Here, we demonstrate that TMZ-derived 5-aminoimidazole-4-carboxamide (AICA) converted AICA ribosyl-5-phosphate (AICAR) in cells. This conversion catalyzed by hypoxanthine phosphoribosyl transferase 1 (HPRT1), which highly expressed human GBMs. As the bona fide activator AMP-activated protein kinase...
EGFRT790M mutation causes resistance to the first-generation tyrosine kinase inhibitors (TKIs) in patients with non-small cell lung cancer (NSCLC). However, therapeutic options for sensitizing first TKIs and delaying emergence of mutant are limited. In this study, we show that quercetin directly binds glucose-6-phosphate dehydrogenase (G6PD) inhibits its enzymatic activity through competitively abrogating NADP+ binding catalytic domain. This inhibition subsequently reduces intracellular...
Glioblastoma, the most lethal primary brain tumor, harbors glioma stem cells (GSCs) that not only initiate and maintain malignant phenotypes but also enhance therapeutic resistance. Although frequently mutated in glioblastomas, function regulation of PTEN PTEN-intact GSCs are unknown. Here, we found directly interacted with MMS19 competitively disrupted MMS19-based cytosolic iron-sulfur (Fe-S) cluster assembly (CIA) machinery differentiated cells. was specifically succinated at cysteine (C)...
Connexins (Cxs), the subunits of gap junction channels, are involved in many physiological processes. Aberrant control Cxs and intercellular communication may contribute to diseases, including promotion cancer. Cd exposure is associated with increased risk human prostate cancer benign prostatic hyperplasia. The roles effects on have, however, not been reported previously. In this study, epithelial cell line RWPE-1 was exposed Cd. A low dose stimulated proliferation along a lower degree an...
Abstract The mechanism of male reproductive toxicity induced by benzo[ a ]pyrene (BaP) is poorly understood. Gap junctional intercellular communication (GJIC) known to play critical role in maintaining spermatogenesis. aim the present study was determine toxic effects BaP Sertoli cells, and explore possibility potential mechanisms BaP‐induced changes level GJIC, relationship between GJIC apoptosis. We treated mouse cell lines (TM4) with different concentrations (0.1–100 μ m ) for 1–48 hours,...
Cr(VI) is broadly applied in industry. exposure places a big burden on public health, thereby increasing the risk of lung squamous cell carcinoma (LUSC). The mechanisms underlying Cr(VI)-induced LUSC remain largely elusive. Here, we report that cancer stem (CSC)/tumour-initiating (TIC)-like subgroup within Cr(VI)-transformed bronchial epithelial cells (CrT) promotes tumourigenesis. Mechanistically, specifically increases expression levels aldehyde dehydrogenase 1A1 (ALDH1A1), CSC marker,...
<p>Supplementary Figures and Figure legends</p>
<p>Supplementary Figures and Figure legends</p>
<div>Abstract<p>Radiotherapy is a major component of standard-of-care treatment for gliomas, the most prevalent type brain tumor. However, resistance to radiotherapy remains concern. Identification mechanisms governing radioresistance in gliomas could reveal improved therapeutic strategies treating patients. Here, we report that mitochondrial metabolic pathways are suppressed radioresistant through integrated analyses transcriptomic data from glioma specimens and cell lines....
<div>Abstract<p>Radiotherapy is a major component of standard-of-care treatment for gliomas, the most prevalent type brain tumor. However, resistance to radiotherapy remains concern. Identification mechanisms governing radioresistance in gliomas could reveal improved therapeutic strategies treating patients. Here, we report that mitochondrial metabolic pathways are suppressed radioresistant through integrated analyses transcriptomic data from glioma specimens and cell lines....