A5102939893- Epigenetics and DNA Methylation
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- Histone Deacetylase Inhibitors Research
- Autophagy in Disease and Therapy
- Cancer-related molecular mechanisms research
- Ubiquitin and proteasome pathways
- Cancer Research and Treatments
- Cancer-related gene regulation
- MicroRNA in disease regulation
- Genomics, phytochemicals, and oxidative stress
- Ferroptosis and cancer prognosis
- Extracellular vesicles in disease
- Glioma Diagnosis and Treatment
- Retinoids in leukemia and cellular processes
- Cancer-related Molecular Pathways
- DNA Repair Mechanisms
- Cell death mechanisms and regulation
- Bone and Dental Protein Studies
- GDF15 and Related Biomarkers
- Biochemical and Molecular Research
- Redox biology and oxidative stress
- Pancreatic and Hepatic Oncology Research
- Drug Transport and Resistance Mechanisms
- Sirtuins and Resveratrol in Medicine
Jinhua Central Hospital
2020-2025
Zhejiang University
2016-2025
Sir Run Run Shaw Hospital
2015-2024
Harbin Medical University
2018-2024
Second Affiliated Hospital of Harbin Medical University
2018-2024
Qingdao Municipal Hospital
2023
Qingdao University
2023
Zhongda Hospital Southeast University
2021
Nanjing Medical University
2011-2019
Xi'an Chest Hospital
2019
Abstract Chemoresistance remains the uppermost disincentive for cancer treatment on account of many genetic and epigenetic alterations. Long non-coding RNAs (lncRNAs) are emerging players in promoting initiation progression. However, regulation function chemoresistance largely unknown. Herein, we identified ARHGAP5-AS1 as a lncRNA upregulated chemoresistant gastric cells its knockdown reversed chemoresistance. Meanwhile, high expression was associated with poor prognosis patients....
Abstract Background Exosomes have emerged as vital biomarkers of multiple cancers and contain abundant circular RNAs (circRNAs). However, the potential for exosomal circRNAs to be used in diagnostics their molecular mechanism action colorectal cancer (CRC) remain unclear. Methods CRC-specific were identified by RNA sequencing, exoRBase database a tissue microarray. The diagnostic performance plasma was evaluated among cancer-free controls, precancer individuals, CRC patients, patients with...
Chemotherapy is the major choice for cancer treatment of early and advanced stages. However, intrinsic or acquired drug resistance significantly restricts clinical efficacy chemotherapy. It critical to develop novel approaches detect overcome resistance. In this study, we demonstrated that accelerated glycolysis played a pivotal role in both cisplatin-resistance gastric cells. The metabolic reprogramming cisplatin-resistant cells was characterized by increased dependence. Inhibition with...
Hydrogels are widely used as wound dressings for healing, but when hydrogels absorb exudate, swelling occurs and compresses the surrounding tissue, affecting healing. A chitosan injectable (CS/4-PA/CAT) hydrogel based on catechol 4-glutenoic acid was prepared to avoid promote After cross-linking by UV light, pentenyl groups formed hydrophobic alkyl chains which give a network thus control its swelling. CS/4-PA/CAT retained their non-swelling long time in PBS solution at 37 °C. had good...
Abstract Background Oxaliplatin resistance is a complex process and has been one of the most disadvantageous factors indeed confrontation in procedure colorectal cancer. Recently, long non-coding RNAs (lncRNAs) have emerged as novel molecules for treatment chemoresistance, but specific molecular mechanisms mediated by them are poorly understood. Methods The lncRNAs associated with oxaliplatin were screened microarray. lncRNA effects on chemoresistance then verified gain- loss-of-function...
Cisplatin is the first-line agent utilized for clinical treatment of a wide variety solid tumors including gastric cancer.However, intrinsic or acquired cisplatin resistance often occurred in patients with cancer and resulted failure therapy.In order to investigate if miRNA involves human cancer, we first screened compared expression miRNAs between resistant cell lines SGC-7901/DDP BGC-823/DDP their sensitive parental cells by microarray followed analysis 2D-GE/MS identify target proteins.We...
Chemotherapy is the main treatment for human cancers including gastric cancer.However, in response to chemotherapeutic drugs, tumor cells can develop drug resistance by reprogramming intracellular metabolic and epigenetic networks maintain their intrinsic homeostasis.Previously, we have established cisplatin-resistant cancer as a resistant model, elucidated XRCC1 core DNA repair mechanism of resistance.This study investigated regulation lysine demethylase 5B (KDM5B) resistance.We found that...
Chemoresistance is one of the most important challenges in clinical management lung cancer. SIRT1 a NAD dependent protein deacetylase and implicated diverse cellular processes such as DNA damage repair, cancer progression. upregulated chemoresistant cells, genetic knockdown or chemical inhibition reversed chemoresistance by enhancing apoptosis activation, accompanied with XRCC1 degradation. E3 ligase β-TrCP catalyzed poly-ubiquitination to promote its proteasome-dependent bound deacetylated...
Chemotherapy is one of the most important approaches for treatment various cancers.However, tumor cells often develop resistance to chemotherapeutic drugs.The microenvironment reconstituted by cytokines secreted from immune was recently found play roles in affecting therapeutic response cells.Herein, we reported that can secrete autocrine confer chemoresistance inactivating proapoptotic autophagy.Through cytokine screening, drug resistant cancer more CCL2 than sensitive cells.Such could not...
ABSTRACT Gastric cancer is a common digestive system tumor with high resistance rate that reduces the sensitivity to chemotherapy. Nutrition therapy an important adjuvant approach favor prognosis of gastric cancer. Dietary amino acids contribute greatly progression by mediating gene expressions, epigenetics, signal transduction, and metabolic remodeling. In present study, 20 types were screened glutamine, glycine serine identified as critical regulators cisplatin (DDP) in cells. Moreover,...
Growth arrest specific 5 (GAS5) is a long noncoding RNA (lncRNA) that regulates the function of cardiovascular cells in various diseases. The current study delved into regulation GAS5 on endothelial progenitor (EPCs) and its potential regulatory mechanism coronary heart disease (CHD). Reverse transcription-quantitative polymerase chain reaction was used to detect expression blood samples EPCs from CHD patients healthy controls. Cell Counting Kit-8, colony formation, flow cytometry, transwell...
To investigate the antioxidative mechanism of snake venom-derived protein C activator (PCA) in mitigating vascular endothelial cell injury. Human umbilical vein cells (HUVECs) were cultured DMEM containing 1.0 g/L D-glucose and exposed to hypoxia (1% O2) for 6 h followed by reoxygenation 2 establish a model oxygen-glucose deprivation/reoxygenation (OGD/R). The was treated with μg/mL PCA alone or combination 2-ME2 (a HIF-1α inhibitor) DMOG stabilizer), intracellular production reactive oxygen...
Background & Aims: Dysregulation of metabolism plays an important role in the development and progression cancers, while underlying mechanisms remain largely unknown.This study aims to explore regulation relevance glycolysis chemoresistance gastric cancer.Methods: Biochemical differences between chemoresistant chemosensitive cancer cells were determined by profiling, microarray gene expression, PCR or western blotting.Cancer cell growth vitro vivo analyzed viability, apoptosis nude mice...
Cancer cells reprogram metabolism to coordinate their rapid growth. They addict on glutamine for adenosine triphosphate generation and macromolecule biosynthesis. In this study, we report that deprivation retarded cell growth induced prosurvival autophagy. Autophagy inhibition by chloroquine significantly enhanced starvation apoptosis activation. Asparagine L-asparaginase exacerbated autophagy blockage. Similar starvation, of with a chemical inhibitor currently under clinical evaluation was...
Long-term application of Tamoxifen (TAM) is usually recommended for hormone receptor positive breast cancer patients.Unfortunately, TAM will inevitably increase the incidence endometrial hyperplasia even cancer.Despite substantial investigations, no effective approaches to prevent TAM-induced carcinogenesis have been acknowledged.In this study, we found that inhibition Nrf2 could be valuable hyperplasia.Upon treatment, mRNA and protein expression autophagy adaptor SQSTM1 was specifically...