A5101597319- Cardiac Valve Diseases and Treatments
- Acupuncture Treatment Research Studies
- Infective Endocarditis Diagnosis and Management
- Cardiac Structural Anomalies and Repair
- Ovarian function and disorders
- Aortic Disease and Treatment Approaches
- Neurological Disease Mechanisms and Treatments
- Reproductive Biology and Fertility
- Cardiomyopathy and Myosin Studies
- Cardiac and Coronary Surgery Techniques
- Mesenchymal stem cell research
- Acute Ischemic Stroke Management
- Tissue Engineering and Regenerative Medicine
- Cancer-related molecular mechanisms research
- Neurological Disorders and Treatments
- Glaucoma and retinal disorders
- Congenital Heart Disease Studies
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Hemodynamic Monitoring and Therapy
- Autophagy in Disease and Therapy
- Optical Imaging and Spectroscopy Techniques
- Plant Micronutrient Interactions and Effects
- Estrogen and related hormone effects
- Transcranial Magnetic Stimulation Studies
Nanjing Medical University
2012-2025
Peking University
2020-2025
Peking University Third Hospital
2022-2025
Nanjing University of Chinese Medicine
2025
Hong Kong Polytechnic University
2025
Guangzhou Medical University
2025
Qingzhou City People's Hospital
2025
AstraZeneca (United States)
2025
University of Tübingen
2024
Affiliated Hospital of Hangzhou Normal University
2021-2024
The use of adult stem cells is limited by the quality and quantity host cells. It has been demonstrated that Wharton's jelly–derived mesenchymal (WJMSCs), a primitive stromal population, could integrate into ischemic cardiac tissues significantly improve heart function. In this randomized, controlled trial, our aim was to assess safety efficacy intracoronary WJMSCs in patients with ST-elevation acute myocardial infarction (AMI). multicenter 116 MI were randomly assigned receive an infusion...
Inflammatory cytokines produced by muscularis macrophages largely contribute to the pathological signs of postoperative ileus (POI). Electroacupuncture (EA) can suppress inflammation, mainly or partly via activation vagal efferent. The goal this study was investigate mechanisms which EA stimulation at an hindlimb region ameliorates inflammation in POI. Methods: Intestinal motility and were examined after 24 h intestinal manipulation (IM)-induced POI mice. Local immune response muscularis,...
Summary Aims Oxidative stress and inflammation have been implicated in the pathogenesis of vascular dementia (VD). Thioredoxin‐interacting protein (TXNIP) plays a vital role oxidative NOD‐like receptor 3 (NLRP3) inflammasome activation. There is evidence that acupuncture has an antioxidative neuroprotective effect VD. In this study, we investigated whether can attenuate cognitive impairment via inhibiting TXNIP‐associated VD rats. Methods Both common carotid arteries were occluded (2‐vessel...
Silicosis has been topping the list of high-incidence occupational diseases in developing countries and cannot be completely cured. Recent advances stem cell research have made possible treatment various including lung fibrosis. The application therapy diseases, particular use adipose-derived mesenchymal cells (AD-MSCs) silicosis, not yet reported. aim study is to explore intervening effect silica-induced fibrosis rats. In this study, we investigated anti-pulmonary effects transplantation...
This study evaluated the effects of hypoxia on heart juvenile four-finger threadfin ( Eleutheronema tetradactylum ) through physiological and transcriptome analysis. Juveniles with an average weight 122.82 g length 24.60 cm were used. Hypoxia significantly increased serum myocardial enzyme activities, including creatine kinase (CK), kinase-MB isoenzyme, lactate dehydrogenase (LDH), α-hydroxybutyrate (HDBH). These indicators initially rose then declined, reflecting cardiac stress suggesting...
1. This study examined whether Paeoniflorin (PF), the major active components of Chinese herb Paeoniae alba Radix, has neuroprotective effect in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model Parkinson's disease (PD). 2. Subcutaneous administration PF (2.5 and 5 mg kg(-1)) for 11 days could protect tyrosine hydroxylase (TH)-positive substantia nigra neurons striatal nerve fibers from death bradykinesia induced by four-dose injection MPTP (20 on day 8. 3. When given at 1 h...
Silicon is one of the most widely used chemical materials, and increasing use silica nanoparticles (SNs) highlights requirement for safety biological toxicity studies. The damaging adverse effects SNs on human hepatocytes remain largely unknown, as do mechanisms involved. In present study, underlying SN‑induced in hepatocyte cell line HL‑7702 were investigated. An MTT assay revealed that following exposure to concentration range 25‑200 µg/ml, viability cells decreased, decreased further with...
Autophagy dysfunctions are involved in the pathogenesis of Parkinson’s disease (PD). In present study, we aimed to evaluate involvement G protein-coupled estrogen receptor (GPER) inhibitory effect insulin-like growth factor-1 (IGF-1) against excessive autophagy PD animal and cellular models. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment significantly induced mouse movement disorder decreased protein level tyrosine hydroxylase (TH) substantia nigra (SN) dopamine (DA) content...
During the development of hepatocellular carcinoma (HCC), mutual adaptation and interaction HCC cells microenvironment play an important role. Benzo(a)pyrene (B[a]P) is a common environmental pollutant, which can induce initiation various malignant tumors, including HCC. However, effects B[a]P exposure on progression potential mechanisms remains largely uninvestigated. Here we found that, after long-term to low dose B[a]P, it activated glucose-regulated protein 75 (GRP75), then induced...
Yougui pills (YGPs) is a classical prescription formula for treating steroid-related osteonecrosis of the femoral head (SONFH) in traditional Chinese medicine (TCM). However, its key ingredients and mechanisms action are still unknown. In study, we used molecular docking network pharmacology to comprehensively investigate mechanism by YGPs impact on SONFH. TCMSP was identify effective active components YGPs. Targets associated with SONFH were extracted from GEO datasets conjunction...
Objective To comprehensively assess the global, regional and national burden of polycystic ovary syndrome (PCOS) in incidence, prevalence, years lived with disability (DLYs) based on Global Burden Disease Study (GBD) 2019. Methods This was a cross-sectional descriptive study. Data PCOS DLYs from 1990 to 2019 were obtained GBD study According commonwealth income, WHO region, sociodemographic index, estimates demonstrated along estimated annual percentage change (EAPC). The EAPC data analyzed...
Obesity is a major public health crisis in the United States (US) affecting 42% of population, exacerbating spectrum other diseases and contributing significantly to morbidity mortality overall. Recent advances pharmaceutical interventions, particularly glucagon-like peptide-1 (GLP-1) receptor agonists (e.g., semaglutide, liraglutide) dual gastric inhibitory polypeptide GLP-1 tirzepatide), have shown remarkable efficacy weight-loss. However, limited access these medications due high costs...
Background: The diagnosis of hepatic sinusoidal obstruction syndrome (HSOS) induced by pyrrolizidine alkaloids is mainly based on clinical investigation. There currently no prognostic index. This study evaluated the quantitative measurement blood pyrrole-protein adducts (PPAs) as a diagnostic and index for alkaloid-induced HSOS. Methods: Suspected drug-induced liver injury patients were prospectively recruited. Blood PPAs quantitatively measured using ultra-performance liquid...
Background and Purpose— Emerging evidence suggests that acupuncture could improve cognitive impairment in vascular dementia by enhancing synaptic plasticity the hippocampus. The purpose of this study is to investigate whether dopamine, a key mediator plasticity, involved improvement. Methods— Vascular model was established bilateral common carotid arteries occlusion male Wistar rats. Three days after operation, animals received treatment for 2 weeks, once daily. D1/D5 receptors antagonist...