A5062614636- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA Research and Splicing
- Fibroblast Growth Factor Research
- Metabolism, Diabetes, and Cancer
- Mechanisms of cancer metastasis
- RNA Interference and Gene Delivery
- Sesame and Sesamin Research
- Nephrotoxicity and Medicinal Plants
- Extracellular vesicles in disease
- RNA modifications and cancer
- Pancreatic function and diabetes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer, Lipids, and Metabolism
- Epigenetics and DNA Methylation
- Advanced Nanomaterials in Catalysis
- Angiogenesis and VEGF in Cancer
- Diabetes and associated disorders
- Kruppel-like factors research
- Wnt/β-catenin signaling in development and cancer
- Phytoestrogen effects and research
Zhejiang University
2019-2025
Zhejiang Normal University
2024
Jinhua Central Hospital
2019-2024
Zhejiang Provincial People's Hospital
2023
Wenzhou Medical University
2014-2017
Abstract Background Oxaliplatin resistance is a complex process and has been one of the most disadvantageous factors indeed confrontation in procedure colorectal cancer. Recently, long non-coding RNAs (lncRNAs) have emerged as novel molecules for treatment chemoresistance, but specific molecular mechanisms mediated by them are poorly understood. Methods The lncRNAs associated with oxaliplatin were screened microarray. lncRNA effects on chemoresistance then verified gain- loss-of-function...
Type 2 diabetes mellitus (T2DM) is a metabolic disorder. Numerous proteins have been identified that are associated with the occurrence and development of T2DM. This study aimed to identify potential core genes pathways involved in T2DM, through exhaustive bioinformatic analyses using GSE20966 microarray profiles pancreatic β‑cells obtained from healthy controls patients The original data were downloaded Gene Expression Omnibus database. Data processed by limma package R software...
Abstract The identification of disease-specific alterations in miRNA expression and the ability to detect miRNAs serum furnish basis for identified potential research value. This study was aimed characterize samples from people with type 2 diabetes mellitus (T2DM) healthy individuals order differential T2DM. In total, 582 participants were recruited. Microarray-based profiles screened pooled two groups (T2DM control). candidates’ validated by reverse transcription quantitative real-time...
MiR-146b has been identified as being overexpressed in human bladder cancer (BCa) and implicated promoting cell invasion. However, its specific involvement BCa growth remains unclear. In this study, we demonstrate that the downregulation of miR-146b significantly suppresses tumorigenic cells both vitro vivo by inducing G0/G1 cycle arrest. Specifically, inhibition resulted a significant reduction colony formation (p < 0.05) anchorage-independent UMUC3 T24T cells, measured soft agar assays,...
Insulin resistance is associated with a greatly increased risk of type 2 diabetes. Administration fibroblast growth factor-1 (FGF-1) resulted in marked improvement insulin sensitivity. However, the underlying molecular mechanism whereby FGF-1 represses remains largely unknown. Here, we sought to delineate role respect its anti-inflammatory capability. In this study, found that had positive effects on glucose intolerance, hepatic lipid accumulation and resistance, while it markedly repressed...
Circular RNAs (circRNAs) are a class of noncoding that involved in the progression many human cancers. The precise gene locus and roles circular RNA from Fibronectin type III domain containing 3B (FNDC3B) OS its mechanisms action have not been fully explored.qRT-qPCR assay was used to determine expressions. CCK8 Assay, EdU assay, wound-healing transwell invasion vivo xenograft were perform functional investigations. RNA-FISH, immunofluorescence, RIP stability analysis applied mechanistic...
The results of our previous study revealed that microRNA (miRNA/miR)‑4530 was upregulated in the serum patients with diabetic retinopathy. TargetScan miRNA database used to identify potential targets miR‑4530 and vasohibin‑1 (VASH1) predicted as one targets. demonstrated able promote angiogenesis human umbilical vein endothelial cells. Therefore, suppressing may be a potentially novel approach towards inhibiting tumor angiogenesis. present aimed investigate function determine whether...
Objective. To offer new prognostic evaluations by exploring potentially distinctive genetic features of hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC). Methods. There were 12 samples for gene expression profiling processes in this study. These included three HCC lesion their matched adjacent nontumor liver tissues obtained from patients with HCC, as well ICC controls collected similarly. In addition to the matrix generated on our own, profiles other cohorts The...
Due to lack of estrogen receptor α (ERα, gene name: ESR1), ERα-negative breast carcinoma is insensitive endocrine therapy, and restoration ERα has become a promising strategy for cancer treatment. Sesamol, naturally occurring phenolic compound, usually extracted from sesame seeds. Previous investigations have unmasked its anti-oxidant anti-inflammation properties. In this study, sesamol induced functional re-expression followed by upregulation downstream pS2 GREB1 genes in carcinoma....
Photoreceptor loss is a primary pathological feature of retinal degeneration (RD) with limited treatment strategies. RNA interference (RNAi) has emerged as promising method gene therapy in regenerative medicine. However, the transfer RNAi therapeutics to photoreceptors and deficiency effective therapeutic targets are still major challenges RD.
Abstract Background Circular RNAs (circRNAs) are a class of noncoding that involved in the progression many human cancers. The precise gene locus and roles circular RNA from Fibronectin type III domain containing 3B (FNDC3B) OS its mechanisms action have not been fully explored. Materials methods qRT-qPCR assay was used to determine expressions. CCK8 Assay, EdU assay, wound-healing transwell invasion vivo xenograft were perform functional investigations. RNA-FISH, immunofluorescence, RIP...