A5027551625- Hedgehog Signaling Pathway Studies
- Pancreatic and Hepatic Oncology Research
- Systemic Lupus Erythematosus Research
- Epigenetics and DNA Methylation
- Immune cells in cancer
- Cancer-related Molecular Pathways
- Acute Kidney Injury Research
- Liver Diseases and Immunity
- Pancreatitis Pathology and Treatment
- Renal and related cancers
- Macrophage Migration Inhibitory Factor
- Autophagy in Disease and Therapy
- Chronic Kidney Disease and Diabetes
- RNA modifications and cancer
- Cancer, Hypoxia, and Metabolism
- Advanced Glycation End Products research
- Genomics, phytochemicals, and oxidative stress
- Vitamin D Research Studies
- Biomarkers in Disease Mechanisms
- Estrogen and related hormone effects
- Peptidase Inhibition and Analysis
- MicroRNA in disease regulation
- Acute Lymphoblastic Leukemia research
- Cancer-related molecular mechanisms research
- Nephrotoxicity and Medicinal Plants
First Affiliated Hospital of Wenzhou Medical University
2016-2025
Wenzhou Medical University
2016-2025
Third Affiliated Hospital of Sun Yat-sen University
2024
Sun Yat-sen University
2024
LMU Klinikum
2019
Chongqing Medical University
2016
Children's Hospital of Chongqing Medical University
2016
Jingning County People's Hospital
2014
Institute of Physiology and Basic Medicine
1991
Institute of Basic Medical Sciences of the Chinese Academy of Medical Sciences
1991
Pancreatic cancer (PC) is an aggressive and metastatic gastrointestinal tumor with a poor prognosis. Persistent activation of the TGF-β/Smad signaling induces PC cell (PCC) invasion infiltration via epithelial-to-mesenchymal transition (EMT). Hedgehog crucial pathway for development transcription factors Gli1/2/3. This study aimed to investigate underlying molecular mechanisms action hedgehog in TGF-β1-triggered EMT PCCs (PANC-1 BxPc-3). In addition, overexpression shRNA techniques were used...
Background and Purpose Renal fibrosis acts as the common pathway leading to development of end‐stage renal disease. Previous studies have shown that resveratrol has anti‐fibrotic activity, but its potential molecular mechanisms action are not well understood. Experimental Approach The effects were assayed in a rat model unilateral ureteral obstruction (UUO) vivo fibroblasts tubular epithelial cells (TECs) stimulated by TGF‐β1 vitro. Gene protein expression levels analysed PCR, Western...
Abstract Niclosamide, a cell-permeable salicylanilide, was approved by the Food and Drug Administration for its anthelmintic efficiency. A growing body of evidence in recent years suggests that niclosamide exhibits potential tumor-suppressive activity. However, role molecular mechanism pancreatic cancer remain unclear. In this study, inhibited proliferation cells (PCCs), induced apoptosis via mitochondrial-mediated pathway, suppressed cell migration invasion antagonizing...
Abstract Patients with pancreatic cancer (PC) show dismal prognosis and high mortality. The development of PC is associated the overactivation STAT3. Here, we have determined that non-peptide small molecule Stattic inhibits by targeting In vitro, treatment time- dose-dependently inhibited proliferation cells (PCCs) reducing c-Myc expression enhancing p53 activity. Consequently, p-Rb, cyclin D1, Chk1, p21 (cell cycle proteins) were downregulated, PCCs arrested at G1 phase, which was also...
Abstract Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumor and associated with poor prognosis. Treatment strategies for PDAC are largely ineffective primarily because of delay in its diagnosis limited efficacy systematic treatment. S100A2 the proliferation, migration, differentiation several tumors; however, effects on molecular mechanisms remain to be explored. We studied underlying effect epithelial–mesenchymal transition (EMT) metastasis cells. found that level...
In radiation oncology, ionizing is used to kill cancer cells, in other words, the induction of different types cell death. To investigate this cellular death and associated iron accumulation, transfer, release, participation after treatment was analyzed. We found that radiation-induced varied breast cells autophagy induced MDA-MB-231 BT549 (triple negative line) rather than MCF-7 zr-75 cells. Iron chelator deferoxamine (DFO), inhibitor 3MA, silencing autophagy-related genes ATG5, Beclin 1...
Abstract Cisplatin‐induced kidney injury (CKI) is a common complication of chemotherapy. Fraxetin, derived from Fraxinus bungeana A. DC . bark, has antioxidant, anti‐inflammatory, and anti‐fibrotic effects. This study aims to investigate fraxetin's effects on CKI its underlying mechanism in vivo vitro. Tubular epithelial cells (TECs) mice were exposed cisplatin with without fraxetin preconditioning assess role CKI. TECs autophagy was observed using transmission electron microscopy. Apoptosis...
The sonic hedgehog (SHH) signaling pathway plays a critical role in embryonic development, tissue regeneration and organogenesis. activation of SHH produces profibrogenic effects various tissues, such as the liver biliary ducts. However, renal fibrogenesis remains to be elucidated. For this purpose, present study, we evaluated hypothesis that activated promotes acquisition myofibroblastic phenotype through epithelial-mesenchymal transition (EMT), resulting interstitial fibrosis (RIF). Kidney...