Lung adenocarcinoma (LUAD) is a highly heterogeneous malignancy, which makes prognosis prediction of LUAD very challenging. Ferroptosis an iron-dependent cell death mechanism that important in the survival tumor cells. Long non-coding RNAs (lncRNAs) are considered to be key regulators development and involved ferroptosis cells, ferroptosis-related lncRNAs have gradually emerged as new targets for treatment prognosis. It essential determine prognostic value LUAD. In this study, we obtained...

Methylenecyclopropanes 1 could be converted to the corresponding cyclobutenes 2 under catalysis of palladium acetate in presence metal bromide 1,2-dichloroethane mild conditions. A plausible reaction mechanism has been proposed on basis deuterium labeling experiment.

Reaction of methylenecyclopropanes 1 with sulfonamides produces the corresponding pyrrolidine derivatives 3 in moderate to good yields under catalysis Au(I) via a domino ring-opening ring-closing hydroamination process.

Acute respiratory distress syndrome (ARDS) is a fatal outcome of severe sepsis. Machine learning models are helpful for accurately predicting ARDS in patients with sepsis at an early stage.

Gold-catalyzed reactions of 2-(ynol)aryl aldehydes were investigated. Benzochromanes obtained from the reaction when AuCl(3) was employed as catalyst, whereas benzobicyclo[n.3.1]acetals produced triazole-gold catalyst. Plausible mechanisms are discussed.

Lung cancer remains the leading cause of death globally, with lung adenocarcinoma (LUAD) being its most prevalent subtype. Due to heterogeneity LUAD, patients given same treatment regimen may have different responses and clinical outcomes. Therefore, identifying new subtypes LUAD is important for predicting prognosis providing personalized patients. Pyroptosis-related genes play an essential role in anticancer, but there limited research investigating pyroptosis LUAD. In this study, 33 gene...

An interesting rearrangement of arylvinylidenecyclopropanes having three substituents at the 1- and 2-positions corresponding cyclopropane catalyzed by Lewis acids to give 6aH-benzo[c]fluorine derivatives via a double intramolecular Friedel−Crafts reaction or an indene derivative is described.

[structure: see text]. Iodobenzene diacetate-mediated reactions of methylenecyclopropanes 1, vinylidenecyclopropanes 2, and a methylenecyclobutane 3a with phthalhydrazide give the corresponding [3+2] cycloaddition products in good yields under mild conditions. In these reactions, was transformed to 1,3-dipole intermediate presence iodobenzene diacetate. A plausible reaction mechanism has been proposed.

Neointimal hyperplasia caused by the excessive proliferation of vascular smooth muscle cells (VSMCs) is pathological basis restenosis. However, there are few effective strategies to prevent Celastrol, a pentacyclic triterpene, has been recently documented be beneficial certain cardiovascular diseases. Based on its significant effect autophagy, we proposed that celastrol could attenuate restenosis through enhancing autophagy VSMCs. In present study, found effectively inhibited intimal and...

(Cyclopropylidenecyclohexyl)benzene derivatives, a kind of methylenecyclopropane (MCP) containing cyclohexyl group, can undergo an interesting tandem intramolecular C-H and C-C bond activation through dehydrogenated rearrangement in the presence AuPPh(3)Cl/AgOTf by transferring three hydrogen atoms from cyclohexane to cyclopropane, affording corresponding biaryl derivatives moderate good yields. The reaction mechanism has also been carefully investigated deuterium labeling experiments DFT...

To determine the prevalence and epidemiology of fecal carriage carbapenem-resistant Enterobacteriaceae (CRE), antimicrobial susceptibility, carbapenemase phenotype/genotype, colistin-resistance gene mcr-1 in a university hospital China.A comprehensive study CRE 704 patients was performed. Multilocus sequence typing (MLST) pulsed-field gel electrophoresis (PFGE) were applied to elucidate molecular isolates.In total, 60 detected stool samples (8.5%), including 42 Klebsiella pneumoniae, 7...

Clear cell renal carcinoma (ccRCC) is characterized by abnormal lipid accumulation. Celastrol a pentacyclic triterpene extracted from Tripterygium wilfordii Hook F with anti-cancer activity. In the present study, anticancer effects of celastrol on ccRCC and underlying mechanisms were studied. Patients reduced high density lipoprotein (HDL) elevated levels triglyceride (TG), total cholesterol (TC), low (LDL) was found to have higher risk ccRCC. clinical samples lines, caveolin-1 (CAV-1)...

A Michael addition of allenoates to electron-deficient olefins was mediated efficiently by a catalytic amount commercial tetra-n-butylammonium fluoride (TBAF) under mild conditions. And 2-alkynyl substituted glutaric acid derivatives, which may be potential building blocks in organic synthesis, were obtained good excellent yields from these reactions. The mechanism for the reaction involve formation an alkynylenolate intermediate.

The reaction of methylenecyclopropanes 1 with phenylsulfenyl chloride or phenylselenyl gives (cyclobut-1-enylsulfanyl)benzene (cyclobut-1-enylselanyl)benzene along ring-opened product in good total yields at 0 °C various solvents. A plausible mechanism has been proposed.

Methylenecyclopropanes undergo an interesting Lewis acid-catalyzed ring-opening reaction with diphenylphosphine oxide in the presence of sulfur or selenium upon heating at 85 degrees C 1,2-dichloroethane to give corresponding homoallylic thiol selenol derivatives good high yields.

Abstract Background The expression of μ-opioid receptor has important role in cognitive dysfunction Schizophrenia (SZ). results studies about the association polymorphisms gene (OPRM1) with SZ were inconsistent. Methods We conducted a case–control study to investigate genetic between OPRM1 and among Han chinese population. 264 patients age-matched control subjects recruited. Four SNPs successfully genotyped by using PCR-RFLP. Results Of four polymorphisms, rs1799971 rs2075572 shown associate...

Background: We previously reported that elevation of intracranial dopamine (DA) levels from cirrhotic livers is implicated in the pathogenesis minimal hepatic encephalopathy (MHE). Intracellular events neurons, which lead to memory loss MHE by elevated DA, however, remain elusive. Methods: In our present study, an rat model, a DA - intracerebroventricularly (i.c.v.) injected model and DA-treated primary cortical neurons (PCNs) were used study this issue using behavioral tests, double-labeled...

The reactions of methylenecyclopropanes 1 with diphenyl diselenide give ring-opened products 2 in good yields at 150 °C under nitrogen atmosphere for 3 h; the can further undergo oxidative cyclization hydrogen peroxide to furnish 3-phenylselenyl-2,5-dihydrofurans moderate (three steps) room temperature CH2Cl2 5 a plausible reaction mechanism has been proposed.