A5026056831- Proteins in Food Systems
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Neurological Complications and Syndromes
- Mesenchymal stem cell research
- Iron Metabolism and Disorders
- Liver Disease and Transplantation
- Acute Ischemic Stroke Management
- Plant Micronutrient Interactions and Effects
- Liver Disease Diagnosis and Treatment
- Graphene and Nanomaterials Applications
- Cerebrovascular and Carotid Artery Diseases
- Botanical Research and Applications
- Nanoparticle-Based Drug Delivery
- Polysaccharides Composition and Applications
- Phytase and its Applications
- Anesthesia and Neurotoxicity Research
- Adrenal and Paraganglionic Tumors
- Tissue Engineering and Regenerative Medicine
- Alzheimer's disease research and treatments
- Surfactants and Colloidal Systems
- Neurological Disease Mechanisms and Treatments
- Spinal Hematomas and Complications
- Pickering emulsions and particle stabilization
- Cerebrovascular and genetic disorders
Tianjin University of Science and Technology
2021-2024
Stanford University
2022-2024
Nanchang University
2024
Hainan University
2024
Palo Alto University
2023
University of North Texas
2016-2022
Medical College of Wisconsin
2022
University of North Texas Health Science Center
2016-2022
University of North Texas System
2020-2022
Capital Medical University
2018-2021
Traumatic brain injury (TBI) is a leading cause of mortality and disability worldwide. Although treatment guidelines have been developed, no best option or medicine for this condition exists. Recently, mesenchymal stem cells (MSCs)-derived exosomes shown lots promise the disorders, with some results highlighting neuroprotective effects through neurogenesis angiogenesis after TBI. However, studies focusing on role in early stages neuroinflammation post-TBI are not sufficient. In study, we...
Fungal infection possesses the characteristics of high invasion depth and easy formation a biofilm under skin, which greatly hinders treatment process. Here, traditional Chinese medicine moxa is carbonized modified with zinc oxide (ZnO) nanosheets to synthesize moxa@ZnO (CMZ) dual response properties yellow light (YL) ultrasound (US) for synergistic antifungal therapy. CMZ narrow bandgap can respond long-wavelength YL that highly safe helpful skin repair. Simultaneously, piezoelectric effect...
Tissue plasminogen activator (tPA) is the only FDA approved thrombolytic drug for acute ischemic stroke but concerns regarding its limitations remain. Here, we developed a new strategy by incorporating tPA into porous magnetic iron oxide (Fe3O4)-microrods (tPA-MRs) targeted therapy in induced distal middle cerebral artery occlusion. We showed that intra-arterial injection of tPA-MRs could target blood clot vivo under guidance an external magnet, where was subsequently released at site...
Neuro-inflammation plays an important role in the recovery of brain injury after stroke. Microglia/macrophage is major executor neuro-inflammation, which can be polarized into two distinct phenotypes: injurious/toxic classical activation (M1 phenotype) and protective alternative (M2 phenotype). Here, we investigated whether intracerebral administration interleukin-4 (IL-4) at early stage could affect microglia/macrophage corresponding outcome hemorrhage (ICH). The neuro-behavior was recorded...
Restricted by synaptic plasticity, dopamine receptor (DR) upregulation takes a long time to work. Moreover, the impact of blood-brain barrier (BBB) on delivery efficiency restricts development drugs. Taking inspiration from snuff bottles, convenient, fast-acting, and nonaddictive nasal drug system has been developed rapidly reshape balance transmitters. This optical magnetic response called CFs@DP, comprised carbonized MIL-100 (Fe) frameworks (CFs) domperidone (DP), which can enter brain via...
Intracranial and extracranial arterial stenosis, the primary cause of chronic cerebral hypoperfusion (CCH), is a critical reason for pathogenesis vascular dementia Alzheimer's disease characterized by cognitive impairments. Our previous study demonstrated that limb remote ischemic conditioning (LRIC) improved perfusion in intracranial stenosis patients. The current aimed to test whether LRIC promotes angiogenesis increases phosphorylated endothelial nitric oxide synthase (p-eNOS) activity...
Magnetic nanoparticles, such as Fe₃O₄ and Co₃O₄, play a vital role in the research on advanced microwave absorbing materials, even if problems high density narrow band impedance matching are still unsolved. Herein, study of lightweight hollow Fe₃O₄@reduced graphite oxide (RGO) nanocomposites synthesized via solvothermal method is presented. The microstructure crystal morphology materials were characterized by X-ray diffractometer (XRD), photoelectron spectroscopy (XPS), scanning electron...
Studies have shown that transplantation of bone marrow-derived mesenchymal stem cells (BMSCs) protects against brain damage. However, the low survival number transplanted BMSCs remains a pertinent challenge and can be attributed to unfavorable microenvironment injured brain. It is well known calpain activation plays critical role in traumatic injury (TBI)-mediated inflammation cell death; previous studies showed inhibiting neuroprotective after TBI. Thus, we investigated whether...
Abstract Anaplastic thyroid cancer (ATC) is the most aggressive cancer. Despite advances in tissue culture techniques, a robust model for ATC spheroid yet to be developed. In this study, we created an efficient and cost-effective 3D tumor spheroids system from human cells existing cell lines that better mimic patient tumors can enhance our understanding of vivo treatment response. We found patient-derived readily form with unique morphology, size, cytoskeletal organization. observed both...