A5088476571- Selenium in Biological Systems
- Heavy Metal Exposure and Toxicity
- Heme Oxygenase-1 and Carbon Monoxide
- Inflammasome and immune disorders
- Trace Elements in Health
- Plant Stress Responses and Tolerance
- Intracerebral and Subarachnoid Hemorrhage Research
- Plant Micronutrient Interactions and Effects
- Neuroinflammation and Neurodegeneration Mechanisms
- Autophagy in Disease and Therapy
- RNA modifications and cancer
- Influenza Virus Research Studies
- Cancer-related molecular mechanisms research
- Heavy metals in environment
- Tuberculosis Research and Epidemiology
- Animal Disease Management and Epidemiology
- Immune cells in cancer
- Mesenchymal stem cell research
- Silicon Effects in Agriculture
- Erythrocyte Function and Pathophysiology
- Metabolomics and Mass Spectrometry Studies
- MicroRNA in disease regulation
- Mercury impact and mitigation studies
- DNA Repair Mechanisms
- Ferroptosis and cancer prognosis
Sichuan Agricultural University
2019-2024
Rice Research Institute
2019-2024
Wenzhou Medical University
2019-2024
First Affiliated Hospital of Wenzhou Medical University
2019-2024
Shantou University
2024
Zhejiang University
2013-2023
Ministry of Agriculture and Rural Affairs
2023
Beijing University of Chemical Technology
2023
Xuzhou Medical College
2023
China Jiliang University
2020-2023
Traumatic brain injury (TBI) is a leading cause of mortality and disability worldwide. Although treatment guidelines have been developed, no best option or medicine for this condition exists. Recently, mesenchymal stem cells (MSCs)-derived exosomes shown lots promise the disorders, with some results highlighting neuroprotective effects through neurogenesis angiogenesis after TBI. However, studies focusing on role in early stages neuroinflammation post-TBI are not sufficient. In study, we...
It is evident from previous reports that 5-aminolevulinic acid (ALA), like other known plant growth regulators, effective in countering the injurious effects of heavy metal-stress oilseed rape (Brassica napus L.). The present study was carried out to explore capability ALA improve cadmium (Cd2+) tolerance B. through physiological, molecular, and proteomic analytical approaches. Results showed application helped plants adjust Cd2+-induced metabolic photosynthetic fluorescence changes leaves...
Traumatic brain injury (TBI) refers to temporary or permanent damage function caused by penetrating objects blunt force trauma. TBI activates inflammasome-mediated pathways and other cell death remove inactive damaged cells, however, they are also harmful the central nervous system. The newly discovered pattern termed pyroptosis has become an area of interest. It mainly relies on caspase-1-mediated pathways, leading death. Our research focus is VX765, a known caspase-1 inhibitor which may...
Cadmium (Cd) is a well-known metal imposing threats to human health, and it can be accumulated in polished rice over the permitted range of 0.2 mg kg-1 (GB 2762-2017). It has been reported that selenium (Se) application decreases Cd uptake. Se-rich diets have gained attention recently, but potential mitigating stress needs further investigation. In this study, pot experiment field was conducted assess influence environmental factors exogenous split Se on nutritional status under stress. The...
Ischemic stroke-induced inflammation and inflammasome-dependent pyroptotic neural death cause serious neurological injury. Nano-sized plasma exosomes have exhibited therapeutic potential against ischemia reperfusion injury by ameliorating inflammation. To enhance its in patients with ischemic injury, we isolated from melatonin-treated rat assessed the protective effect a model of focal cerebral ischemia.Basal were intravenously injected into ischemia. Neurological recovery was evaluated...
Countries face exasperating and inclement climate worldwide. Food feed security could be their paramount life objective. The study aimed to investigate the impact of selenium on protein content distribution in different parts rice. For this purpose, advanced biofortified breeding material developed after generations efforts was investigated at field area, rice research institute, Chengdu, China during cropping season 2021–22. accumulation contents were observed various fractions...
Chromium (Cr) as a toxic metal is widely used for commercial purposes and its residues have become potential environmental threat to both human plant health. Oilseed rape (Brassica napus L.) one of the candidate plants that can absorb considerable quantity metals from soil. Here, we two cultivars B. cvs. ZS 758 (metal-tolerant) Zheda 622 (metal-susceptible) investigate phenological attributes, cell ultrastructure, protein kinases (PKs) molecular transporters (MTs) under combined treatments...
Rapid diagnosis of pulmonary tuberculosis is an effective measure to prevent the spread tuberculosis. However, grim fact that new, rapid, and safe methods for clinical are lacking. Moreover, although auto-lysosome critical in clearing Mycobacterium tuberculosis, pathological significance microRNAs, as biomarkers autophagosome maturation unclear. Here, these microRNAs were investigated by Solexa sequencing qPCR validation, a potential diagnostic model was established logistic regression....
Ischemia/reperfusion (I/R) injury is a significant cause of mortality and long-term disability worldwide. Recent evidence has proved that pyroptosis, novel cell death form, contributes to inflammation-induced neuron neurological function impairment following ischemic stroke. Gasdermin D (GSDMD) newly discovered key molecule but its biological precise role in stroke are still unclear. The present study investigates the cleavage activity GSDMD, localization pyroptotic cells, global...
Abstract Aims The therapeutic effect of bone marrow stromal cell (BMSC) transplantation for ischemic stroke is limited by its low survival rate. purpose this study was to evaluate whether Roxadustat (FG‐4592) pretreatment could promote the rate grafted BMSCs and improve neurological function deficits in ischemia rats. Methods Oxygen–glucose deprivation (OGD) permanent middle cerebral artery occlusion (pMCAO) were constructed as models vitro vivo. Flow cytometry analysis expression Bax Bcl‐2...
Abstract Pulmonary tuberculosis (TB) is among the diseases with highest morbidity and mortality worldwide. Effective diagnostic methods for TB are lacking. In this study, we investigated long non-coding RNAs (lncRNAs) in plasma using microarray potential value of lncRNAs TB. We found a total 163 up-regulated 348 down-regulated lncRNAs. Gene ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG) coding-noncoding co-expression (CNC) analyses showed that functions differentially expressed were...
The endogenous metabolite itaconate and its cell‑permeable derivative dimethyl (DI) have been identified as anti‑inflammatory regulators of macrophages; however, their contribution to inflammasome‑mediated pyroptosis remains unknown. present study examined the molecular mechanism DI on NLR family pyrin domain‑containing 3 (NLRP3) inflammasome assembly NLRP3 inflammasome‑dependent in microglia. Lipopolysaccharide (LPS) ATP were used induce microglia <em>in vitro</em>; this process was...
Using transthoracic echocardiography (TTE) and transesophageal (TEE) to investigate the occurrence related causes of iatrogenic atrial septal defect (iASD) after catheter ablation combined with left appendage closure (LAAC) for fibrillation (AF) its impact on right heart system. We retrospectively analyzed 330 patients that underwent procedure AF LAAC at General Hospital Northern Theater Command from January 2018 March 2022. These were divided into iASD group non-iASD according whether there...