A5103137269- Hepatitis B Virus Studies
- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- Neuroinflammation and Neurodegeneration Mechanisms
- Intracerebral and Subarachnoid Hemorrhage Research
- Inflammasome and immune disorders
- Acute Ischemic Stroke Management
- Extracellular vesicles in disease
- Dental Implant Techniques and Outcomes
- Heme Oxygenase-1 and Carbon Monoxide
- Ferroptosis and cancer prognosis
- Ultrasound Imaging and Elastography
- Immunotherapy and Immune Responses
- Mesenchymal stem cell research
- Immune cells in cancer
- Traumatic Brain Injury and Neurovascular Disturbances
- Ultrasound and Hyperthermia Applications
- Barrier Structure and Function Studies
- Gynecological conditions and treatments
- Cancer, Stress, Anesthesia, and Immune Response
- Cerebrovascular and Carotid Artery Diseases
- Reproductive System and Pregnancy
- Autophagy in Disease and Therapy
- IL-33, ST2, and ILC Pathways
Wenzhou Medical University
2012-2025
First Affiliated Hospital of Wenzhou Medical University
2011-2025
Beijing YouAn Hospital
1993-2023
Capital Medical University
2019-2023
Capital University
2023
Zaozhuang Municipal Hospital
2022
Shanghai Stomatological Hospital
2020-2022
Northwestern Polytechnical University
2021
First Affiliated Hospital of Fujian Medical University
2017
Fujian Medical University
2017
Traumatic brain injury (TBI) is a leading cause of mortality and disability worldwide. Although treatment guidelines have been developed, no best option or medicine for this condition exists. Recently, mesenchymal stem cells (MSCs)-derived exosomes shown lots promise the disorders, with some results highlighting neuroprotective effects through neurogenesis angiogenesis after TBI. However, studies focusing on role in early stages neuroinflammation post-TBI are not sufficient. In study, we...
Ischemic stroke-induced inflammation and inflammasome-dependent pyroptotic neural death cause serious neurological injury. Nano-sized plasma exosomes have exhibited therapeutic potential against ischemia reperfusion injury by ameliorating inflammation. To enhance its in patients with ischemic injury, we isolated from melatonin-treated rat assessed the protective effect a model of focal cerebral ischemia.Basal were intravenously injected into ischemia. Neurological recovery was evaluated...
Intracerebral hemorrhage (ICH) refers to bleeding in the brain and is associated with release of large amount inflammasomes, activation different cell death pathways. These pathways lead removal inactivated damaged cells also result neuronal damage. Pyroptosis a newly discovered pathway that has gained attention recent years. This mainly depends on caspase-1-mediated cascades cause death. We tested well-known selective inhibitor caspase-1, AC-YVAD-CMK, which previously been found have...
Ischemia/reperfusion (I/R) injury is a significant cause of mortality and long-term disability worldwide. Recent evidence has proved that pyroptosis, novel cell death form, contributes to inflammation-induced neuron neurological function impairment following ischemic stroke. Gasdermin D (GSDMD) newly discovered key molecule but its biological precise role in stroke are still unclear. The present study investigates the cleavage activity GSDMD, localization pyroptotic cells, global...
In this study, the characteristic patterns of ferroptosis in clear cell renal carcinoma (ccRCC) were systematically investigated with interactions between and tumor microenvironment (TME). On mRNA expression profiles 57 ferroptosis-related genes (FRGs), three constructed, distinct prognosis immune infiltrations (especially T cells dendritic cells). The high scores characterized by poorer prognosis, increased infiltration, higher stromal scores, elevated mutation burden, enhanced response to...
Abstract Aims The therapeutic effect of bone marrow stromal cell (BMSC) transplantation for ischemic stroke is limited by its low survival rate. purpose this study was to evaluate whether Roxadustat (FG‐4592) pretreatment could promote the rate grafted BMSCs and improve neurological function deficits in ischemia rats. Methods Oxygen–glucose deprivation (OGD) permanent middle cerebral artery occlusion (pMCAO) were constructed as models vitro vivo. Flow cytometry analysis expression Bax Bcl‐2...
Lung health is intricately linked with inflammation. The pan-immune-inflammation value (PIV) emerges as a promising biomarker, offering reflection into systemic inflammatory states and assisting in the prognosis of diverse diseases. This research aims to explore associations between PIV respiratory symptoms, diseases lung function. study was cross-sectional population from National Health Nutrition Examination Survey (NHANES). Restricted cubic spline (RCS) models were conducted relationships...
The endogenous metabolite itaconate and its cell‑permeable derivative dimethyl (DI) have been identified as anti‑inflammatory regulators of macrophages; however, their contribution to inflammasome‑mediated pyroptosis remains unknown. present study examined the molecular mechanism DI on NLR family pyrin domain‑containing 3 (NLRP3) inflammasome assembly NLRP3 inflammasome‑dependent in microglia. Lipopolysaccharide (LPS) ATP were used induce microglia <em>in vitro</em>; this process was...
In China, it is common for pregnant women with a high load of hepatitis B virus (HBV) to take nucleos(t)ide analogue (NA) prevent maternal-to-child transmission HBV. However, the impact NA intervention on virological and biochemical parameters in postpartum safety drug cessation remain unclear. A prospective observational cohort was established this study analyze clinical characteristics flares chronic HBV carriers, or without intervention.Pregnant who were carriers enrolled divided into an...
Exosomes have gained increased research focus due to their key roles as messengers. The components of exosomes include proteins and RNAs that may be horizontally transferred between adjacent or distant cells. Hepatocellular carcinoma (HCC) is among the most malignant types cancer worldwide, with implicated play a crucial role in its regulation; however, possible function modulating motile ability tumor cells molecules HCC remain largely unknown. To investigate regulatory effect on cells,...
Ferroptosis and inflammation induced by cerebral hemorrhage result in an excessive inflammatory response irreversible neuronal injury. Alleviating ferroptosis might be effective way to prevent neuroinflammatory injury promote neural functional recovery. Pyridoxal isonicotinoyl hydrazine (PIH), a lipophilic iron-chelating agent, has been reported reduce excess iron-induced cytotoxicity. However, whether PIH could ameliorate the effects of hemorrhagic stroke is not completely understood. In...
Background The extent of the increase in postpartum alanine transaminase (ALT) varies significantly among pregnant women immune tolerance stage nucleoside analogue (NA) intervention, so this study is an attempt to analyze clinical features patients with and without hepatitis flare preliminarily explore differences their functions. Methods Pregnant a gestational age 24–28 w NA intervention for B virus (HBV) infection were included divided into group (Group 1) nonhepatitis 2) according ALT...
Thyroid disorders (TD) is a common complication of pegylated-interferon alpha (Peg-IFNα) therapy. Few studies have investigated the relationship between TD and efficacy interferon therapy for chronic hepatitis B (CHB). Therefore, we analyzed clinical characteristics in patients with CHB treated Peg-IFNα, evaluated correlation Peg-IFNα treatment efficacy.In this retrospective study, data 146 receiving were collected analyzed.During course therapy, positive conversion thyroid autoantibodies...
The tumor microenvironment (TME) plays an important role in the growth and invasion of glioma. This study aimed to analyze composition immune glioma samples differentially expressed genes identify novel immune-targeted therapy for We downloaded transcriptomic data 669 from Cancer Genome Atlas database. CIBERSORT ESTIMATE methods were used calculate proportion tumor-infiltrating cells ratio stromal components TME. (DEGs) screened by comparing both cells. Annexin A1 (ANXA1) was determined be...
Recurrence is common for patients with chronic hepatitis B (CHB) who achieved virus (HBV) surface antigen (HBsAg) clearance after antiviral treatment. The aim of the study to explore possibility quantitative core antibody (Anti-HBc) level as a biomarker predict recurrence. A total 73 HBsAg were enrolled in this study, 16 cases recurrence and 57 non-recurrence. newly developed double-sandwich Anti-HBc immunoassay was used detect before therapy (baseline) at end therapy. Logistic regression...
To identify biomarkers and develop an inflammatory score based on proper integration to improve risk prediction of delayed cerebral ischemia (DCI) poor outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). We also further explore the mediation interaction DCI within chain events using four-way effect decomposition. Machine learning algorithms are used for biomarker selection constructed score. Multivariate logistic regression was performed association outcome. Next, we employed...