A5002705488- Hepatitis C virus research
- Hepatitis B Virus Studies
- HIV Research and Treatment
- Liver Disease Diagnosis and Treatment
- Hepatitis Viruses Studies and Epidemiology
- HIV/AIDS drug development and treatment
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Immunodeficiency and Autoimmune Disorders
- HIV/AIDS Research and Interventions
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Tryptophan and brain disorders
- Remote-Sensing Image Classification
- Platelet Disorders and Treatments
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- HER2/EGFR in Cancer Research
- Stress Responses and Cortisol
- HIV, TB, and STIs Epidemiology
- Complement system in diseases
- Skin and Cellular Biology Research
- Child and Adolescent Health
- interferon and immune responses
- Remote Sensing in Agriculture
Shandong University of Traditional Chinese Medicine
2024-2025
University of Florida Health
2025
University of Florida
2025
Capital Medical University
2014-2024
Beijing YouAn Hospital
2014-2024
Chongqing Medical University
2024
China Agricultural University
2024
Ministry of Agriculture and Rural Affairs
2024
Incheon St. Mary's Hospital
2019
Catholic University of Korea
2019
Abstract Background Safe nucleos(t)ide analogue discontinuation in chronic hepatitis B (CHB) is an unmet need. We aimed to investigate whether combining virus (HBV) RNA and core–related antigen (HBcrAg) could perform satisfactorily predicting off-treatment outcomes. Methods The evaluation cohort included 127 e (HBeAg)–positive patients from a multicenter prospective trial who stopped telbivudine-based therapy after achieving HBeAg seroconversion HBV DNA < 50 IU/mL for > 48...
The safety of the immune complexes composed yeast-derived hepatitis B surface antigen (HBsAg) and antibodies (abbreviated as YIC) among healthy adults chronic patients has been proved in phase I IIa trial. A larger number for study dosage efficacy are therefore needed.Two hundred forty two HBeAg-positive were immunized with six injections either 30 microg YIC, 60 YIC or alum adjuvant placebo at four-week intervals under code. HBV markers DNA monitored during immunization 24 weeks after...
Hepatitis B surface antigen (HBsAg) seroclearance has been recommended as an optimal endpoint of antiviral treatment by the latest chronic hepatitis management guideline.1 However, few reports investigated durability response after HBsAg seroclearance, because a lower rate and difficulty obtaining sufficient number samples for analysis. Our center made long-term commitment to investigate personalized therapy B. More than 300 patients achieved interferon (IFN)-based treatment. In this study,...
Melanoma, with its high degree of malignancy, stands as one the most dangerous skin cancers and remains primary cause death from cancer. With studies demonstrating potential traditional Chinese medicine to intervene treat melanoma, we turned our attention celastrol. Celastrol is a triterpene compound extracted derived Tripterygium wilfordii. Previous have shown that celastrol exerts inhibitory effects on various malignant tumors, including melanoma. Hence, goal was clarify impact cell...
Background & AimsHBsAg loss is only observed in a small proportion of patients with chronic hepatitis B (CHB) who undergo interferon treatment. Investigating the host factors crucial for CHB functional cure can aid identifying individuals would benefit from Peginterferon-alpha (Peg-IFNα) therapy.MethodsWe conducted Genome-wide association study (GWAS) by enrolling 48 HBsAg and 47 persistence after Peg-IFNα In validation stage, we included total 224 samples, out which 90 achieved loss, to...
Abstract Background & Aims Currently, routine antiviral treatment is not recommended for immune‐tolerant subjects with chronic HBV infection. In this study, we assessed the efficacy of combining Peg IFN α‐2a Adefovir ( CPIA ) in infected pregnant women normal levels ALT and high after delivery. Methods Chronic hepatitis B DNA were treated Telbivudine during third trimester their pregnancy. After childbirth, based on serological virological parameters, patients either switched to 96 weeks...
Abstract This study presents the first physiologically based pharmacokinetic (PBPK) model for deucravacitinib, a novel oral selective tyrosine kinase 2 (TYK2) inhibitor approved treating moderate‐to‐severe plaque psoriasis. Using GastroPlus, we developed and validated comprehensive PBPK incorporating multiple elimination pathways enterohepatic circulation. The was calibrated using single‐dose data (3‐40 mg) from healthy adults against external datasets clinical studies across different...
As advice and consensus on the pegylated-interferon (Peg-IFN) treatment for chronic hepatitis B (CHB) in China, Expert Advice Peg-IFN Treatment CHB was published Chinese Journal of Infectious Diseases 2007, updated 2010 2012.1,2 Previous versions described optimized patients (baseline guided therapy; BGT), basic principles adjustment according to response therapy (response guidance RGT), dosage based adverse effects symptomatic towards reactions. a supplement clinical guidelines management,...
Thyroid disorders (TD) is a common complication of pegylated-interferon alpha (Peg-IFNα) therapy. Few studies have investigated the relationship between TD and efficacy interferon therapy for chronic hepatitis B (CHB). Therefore, we analyzed clinical characteristics in patients with CHB treated Peg-IFNα, evaluated correlation Peg-IFNα treatment efficacy.In this retrospective study, data 146 receiving were collected analyzed.During course therapy, positive conversion thyroid autoantibodies...
Change detection, a critical and flourishing Earth observation technology, aims to identify changes through cross-temporal remote sensing images acquired over the same geographical area. With widespread use in various change scenarios, it becomes essential utilize heterogeneous due high challenge of accessing ideal homogeneous images. Nevertheless, domain shift, generated by different imaging factors (e.g., sensors, seasons, atmosphere, illumination), makes unable compare directly. To...
Accumulated evidences show that neuroinflammation play a pivotal role in the pathogenesis of depression. Neuropeptide Y (NPY) and its receptors have been demonstrated to anti-inflammative as well antidepressant effects. In present study, ability NPY modulate depressive-like behaviors induced by lipopolysaccharides (LPS) rats signaling mechanisms involved were investigated. Continuous injection LPS (i.p) for 4 days led development rats, accompanied with M1-type microglia activation increased...
25 men with chronic hepatitis B virus (HBV) who acquired acute HIV exhibited decreased HBV DNA during infection. Three obtained surface antigen (HBsAg) seroconversion, and 10 “e” seroconversion. Background. Coinfection human immunodeficiency (HIV) is common. Most studies have concentrated on the effects of infection infection; however, are especially important to elucidate potential mechanisms leading complications from HIV/HBV coinfection. Methods. We evaluated DNA, (HBsAg), (HBeAg) in...
Abstract Background The intermediate filament proteins keratins 18 (K18) and 8 (K8) polymerize to form the cytoskeletal network in mature hepatocytes. It has been shown that phosphorylation of K18 at two serine residues, 33 52, correlates with progression hepatitis C, but little is known chronic B (CHB). In this study, we examined relation CHB. Results Site-specific was determined livers twelve healthy donors, non-cirrhosis (n = 40) cirrhosis 21) patients. On average, progressively higher...
The role of preexisting minority drug-resistance mutations in treatment failure has not been fully understood chronic hepatitis B patients. To understand mechanisms drug resistance, we analyzed 46 treatment-failure patients and 29 treatment-naïve determined linkage patterns the individual viral genomes using a highly sensitive parallel allele-specific sequencing (PASS) method. Lamivudine resistance (LAMr) were predominant patients, irrespective inclusion LAM regimen. primary LAMr M204V M204I...
Background and Aims: Data are limited on the use of pegylated-interferon alpha-2a (peg-IFNα) in Chinese patients with chronic hepatitis B virus (HBV) infection (CHB). We evaluated effectiveness safety peg-IFNα envelope antigen-negative CHB routine clinical practice. Methods: In this prospective, multicenter, observational, non-interventional cohort study, were assessed for up to 1 year after treatment cessation. Treating physicians established dosing duration according Effectiveness was...
Background: Soluble oligomeric amyloid-β (Aβ)-induced synaptic dysfunction is an early event in Alzheimer’s disease (AD) pathogenesis. Mounting evidence has suggested N-methyl-D-aspartate receptors (NMDARs) play important role Aβ-induced synaptotoxicity. Originally NMDARs were believed to be expressed exclusively neurons; however, recent two decades studies have demonstrated functional present on astrocytes. Neuronal are modulators of neurodegeneration, while our previous initial study found...
Hepatitis B surface antigen clearance or seroconversion is rarely achieved for patients using nucleoside analogs pegylated interferon alpha monotherapy approaches. Several recent studies have confirmed the benefit of a combination these two approaches selected chronic hepatitis patients. However, few reports investigated long-term outcomes health economic evaluation clearance. The aim this study was to perform cost-effectiveness analysis use strategy among e antigen-negative patients.Drawing...