A5085413475- Advanced Polymer Synthesis and Characterization
- biodegradable polymer synthesis and properties
- Nanoparticle-Based Drug Delivery
- Polymer Surface Interaction Studies
- Nanoplatforms for cancer theranostics
- Dendrimers and Hyperbranched Polymers
- RNA Interference and Gene Delivery
- Silicone and Siloxane Chemistry
- Hydrogels: synthesis, properties, applications
- Advancements in Battery Materials
- Advanced biosensing and bioanalysis techniques
- Advanced Battery Materials and Technologies
- Advanced Battery Technologies Research
- Surfactants and Colloidal Systems
- Supramolecular Self-Assembly in Materials
- Graphene and Nanomaterials Applications
- Polymer composites and self-healing
- Surface Modification and Superhydrophobicity
- Advanced Sensor and Energy Harvesting Materials
- Conducting polymers and applications
- Luminescence and Fluorescent Materials
- Click Chemistry and Applications
- Synthetic Organic Chemistry Methods
- Block Copolymer Self-Assembly
- Electrospun Nanofibers in Biomedical Applications
Xiamen University
2025
Soochow University
2015-2024
Civil Aviation University of China
2023
Beijing University of Technology
2022
Panyu District Central Hospital
2022
Chemical Synthesis Lab
2014-2021
South Florida Veterans Affairs Foundation for Research and Education
2015-2021
State Grid Corporation of China (China)
2021
Suzhou Research Institute
2014-2018
Miami VA Healthcare System
2016
Frank-Kasper (F-K) and quasicrystal phases were originally identified in metal alloys only sporadically reported soft materials. These unconventional sphere-packing schemes open up possibilities to design materials with different properties. The challenge is how correlate complex built from spheres the tunable parameters of chemical composition molecular architecture. Here, we report a complete sequence various highly ordered mesophases by self-assembly specifically designed synthesized...
Polyphosphoester modified cellulose nanocrystals (CNCs) (CNC-<italic>g</italic>-PEEP) have been synthesized through a “grafting onto” process and used for pH-triggered delivery of doxorubicin.
The limited self-repair capacity of articular cartilage has motivated the development stem cell therapy based on artificial scaffolds that mimic extracellular matrix (ECM) tissue. In view specificity cartilage, desirable tissue adhesiveness and stable mechanical properties under cyclic loads are critical for scaffolds. Herein, we developed an injectable degradable organic-inorganic hybrid hydrogel as a scaffold polyhedral oligomeric silsesquioxane (POSS)-cored polyphosphate polysaccharide....
Novel pH- and temperature-responsive double-hydrophilic diblock copolymers, poly(ethylethylene phosphate)-block-poly[2-(dimethylamino)ethyl methacrylate] (PEEP-b-PDMAEMA), have been synthesized via the combination of ring-opening polymerization (ROP) atom transfer radical (ATRP). The PEEP block with a bromine-terminated end (PEEP-Br) was first prepared by ROP 2-ethoxy-2-oxo-1,3,2-dioxaphospholane (EEP) using 2-hydroxyethyl 2-bromoisobutyrate as bifunctional initiator stannous octoate...
Abstract A series of well‐defined amphiphilic triblock copolymers [polyethylene glycol monomethyl ether]‐ block ‐poly(ε‐caprolactone)‐ ‐poly[2‐(dimethylamino)ethyl methacrylate] (mPEG‐ b ‐PCL‐ ‐PDMAEMA or abbreviated as mPEG‐ ‐PDMA) were prepared by a combination ring‐opening polymerization and atom transfer radical polymerization. The chemical structures compositions these have been characterized Fourier transform infrared spectroscopy, 1 H NMR, thermogravimetric analysis. molecular weights...
A reduction-cleavable polyphosphoester-camptothecin (CPT) prodrug tailored for enhancing drug loading content and triggering release has been prepared applied in tumor chemotherapy.
Amphiphilic polymeric prodrugs show improved therapeutic indices with respect to traditional hydrophobic anticancer drugs because these can self-assemble into nanoparticles, prolong the circulation of in blood, improve accumulation disease site, reduce side effects drugs, and achieve effect. Here, we describe a novel pH/reduction dual-responsive prodrug, abbreviated as CPT-ss-poly(BYP-hyd-DOX-co-EEP), simultaneous conjugating camptothecin (CPT) doxorubicin (DOX), wherein BYP EEP represent...
The hybrid hydrogel composed of drug loaded mesoporous silica and pH/glucose-responsive copolymer was used for the healing diabetic foot ulcers.
A series of acid-cleavable ABA-type triblock copolymers, namely poly(ε-caprolactone)-acetal-poly(ethylene glycol)-acetal-poly(ε-caprolactone) (PCL-a-PEG-a-PCL), were synthesized via a combination ring-opening polymerization (ROP) ε-caprolactone initiated by propargyl alcohol and subsequent "CuAAC" click reaction with azide terminated acetal-containing poly(ethylene glycol). The chemical composition structures the copolymers characterized 1H NMR FT-IR spectroscopy, while their molecular...
Two types of stimuli-sensitive polymeric prodrugs for combinatorial cancer therapy have been prepared and found to exhibit favorable anticancer activity<italic>in vitro</italic>and<italic>in vivo</italic>.
PEGylated doxorubicin (DOX) prodrugs with high drug loading content have been prepared <italic>via</italic> a combination of CuAAC “click” reaction and ammonolysis reaction, which can be used for pH-triggered delivery doxorubicin.
A multifunctional bioreducible system based on galactosamine-modified PEEP-<italic>a</italic>-PCL-<italic>ss</italic>-PDMAEMA has been prepared and used for the targeted co-delivery of doxorubicin DNA.
The development of novel stimuli-responsive and biodegradable polyphosphoester-anticancer prodrugs is importance in designing water-soluble utilized the field drug delivery. In this study, focus on synthesis biocompatible diselenide-containing polyphosphoester [PEEP-b-PBYP-Se]2 using reduction-responsive di(1-hydroxylundecyl) diselenide as an initiator to polymerize 2-(but-3-yn-1-yloxy)-2-oxo-1,3,2-dioxaphospholane (BYP) 2-ethoxy-2-oxo-1,3,2-dioxaphospholane (EOP). After that, a doxorubicin...
Modulating MWD through precise blending of discrete macromolecules provides a model platform for highlighting the importance chain length heterogeneity.
Polyphosphoesters (PPEs), as potential candidates for biocompatible and biodegradable polymers, play an important role in material science. Various synthetic methods have been employed the preparation of PPEs such polycondensation, polyaddition, ring-opening polymerization, olefin metathesis polymerization. In this study, a series linear has prepared via one-step Michael addition Subsequently, camptothecin (CPT) derivatives containing disulfide bonds azido groups were linked onto side chain...
Cyclic brush (cb) copolymers that are composed of a cyclic core densely grafted with radiating polymer brushes have emerged recently as innovative materials for both fundamental and practical investigations due to their capability form unimolecular micelles greater stability relative the analogues self-assembled by bottlebrush (bb) an identical molecular weight (MW). However, compared extensive intensive studies on cb homogeneous brushes, preparation application heterogeneous grafts remains...
Polymeric micelles have demonstrated wide utility for chemodrug delivery, which however, still suffer from shortcomings such as undesired drug loading, disassembly upon dilution, pre-leakage of cargoes during systemic circulation, and lack cancer-selective release. Herein, a poly(ethylene glycol) (PEG)-polyphosphoester-based, reactive oxygen species (ROS)-responsive, core-cross-linked (CCL) micellar system was developed to encapsulate both (doxorubicin, Dox) photosensitizer (chlorin e6,...