A5101686587- Advanced Polymer Synthesis and Characterization
- Nanoparticle-Based Drug Delivery
- Hydrogels: synthesis, properties, applications
- Dendrimers and Hyperbranched Polymers
- Polymer Surface Interaction Studies
- Photodynamic Therapy Research Studies
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Porphyrin and Phthalocyanine Chemistry
- Graphene and Nanomaterials Applications
- Advanced Drug Delivery Systems
- Porphyrin Metabolism and Disorders
- Advanced biosensing and bioanalysis techniques
- Advanced Sensor and Energy Harvesting Materials
- Surfactants and Colloidal Systems
- Vitamin D Research Studies
- Microfluidic and Capillary Electrophoresis Applications
- Supramolecular Chemistry and Complexes
- Conducting polymers and applications
- Luminescence and Fluorescent Materials
- Mass Spectrometry Techniques and Applications
- Electrospun Nanofibers in Biomedical Applications
- Synthesis and properties of polymers
- Rock Mechanics and Modeling
- Electrochemical sensors and biosensors
Lanzhou University
2011-2025
State Key Laboratory of Applied Organic Chemistry
2009-2024
First Affiliated Hospital of Zhengzhou University
2024
University of Science and Technology Beijing
2024
Ya'an Polytechnic College
2023
Qiqihar Medical University
2021
Oslo University Hospital
2009-2021
University of South China
2021
Lanzhou City University
2016-2020
China Nonferrous Metal Mining (China)
2016-2020
Lung cancer (LC) with its different subtypes is generally known as a therapy resistant the highest morbidity rate worldwide. Therapy resistance of tumor thought to be related stem cells (CSCs) within tumors. There have been indications that lung propagated and maintained by small population CSCs. To study this question we established panel 15 primary cell lines (PLCCLs) from 20 fresh tumors using robust serum-free culture system. We subsequently focused on identification CSCs studying these...
Abstract The properties of a new photosensitizer, meso‐tetra‐hydroxyphenyl‐chlorin (mTHPC), were studied using V79 cells (Chinese‐hamster lung fibroblasts). Comparisons made with 2 other photosensitizers: photofrin II (PII) and meso‐tetra‐hydroxyphenyl‐porphyrin (mTHPP). A main advantage mTHPC is that it has strong absorption at 652 nm. Maximal cellular uptake the dye was observed after 24 hr incubation drug. Using confocal laser‐scanning fluorescence microscope, we diffuse distribution m...
Self-assembly of amphiphilic block copolymers into well-defined nanostructures as drug delivery systems for the treatment cancer has been a hot subject research. However, sequential polymerizations synthesized with covalent links suffered mainly from multistep synthesis and purification procedures well repeated optimization polymer composition to form aggregates structures. To overcome these drawbacks, supramolecular noncovalent were developed provide simplicity required. Herein, we designed...
Cyclic brush (cb) copolymers that are composed of a cyclic core densely grafted with radiating polymer brushes have emerged recently as innovative materials for both fundamental and practical investigations due to their capability form unimolecular micelles greater stability relative the analogues self-assembled by bottlebrush (bb) an identical molecular weight (MW). However, compared extensive intensive studies on cb homogeneous brushes, preparation application heterogeneous grafts remains...
Abstract Flexible temperature sensors often use gels to achieve skin‐inspired softness, but the water evaporation and freezing of hydrogel leakage ionogel, cause unstable signal transmission inaccurate measurement at sub‐zero temperatures. Here steady hypothermic sensing is achieved by designing a supramolecular elastomer containing two types segments: liquid‐free iontronic segment transmit electrical charges prevent ion leakage, neutral with pendant chains damp vibration for stable...
Interpenetrating network structures from Graphene foam (GF) and 58S bioactive glass (BG) are synthesized to combine the highly mechanical stability conductivity graphene with superb bioactivity biocompatibility BG. GF/58S BG scaffolds were prepared via multiple steps including chemical vapor deposition (CVD), spin-coating, freeze drying methods. Simulated body fluid test confirms of as-synthesized scaffold after incorporating sol-gel derived The also remains good electrical combination...
Radioligand therapy targeting the prostate-specific membrane antigen (PSMA) is rapidly evolving as a promising treatment for metastatic castration-resistant prostate cancer. The PSMA-targeting ligand p-SCN-Bn-TCMC-PSMA (NG001) labelled with 212Pb efficiently targets PSMA-positive cells in vitro and vivo. aim of this preclinical study was to evaluate therapeutic potential 212Pb-NG001 multicellular tumour spheroid mouse models cytotoxic effect tested human C4-2 spheroids. Biodistribution at...
The preparation of tumor acidic pH-cleavable polymers generally requires tedious postpolymerization modifications, leading to batch-to-batch variation and scale-up complexity. To develop a facile universal strategy, we reported in this study design successful synthesis dual functional monomer, a-OEGMA that bridges methacrylate structure oligo(ethylene glycol) (OEG) units via an acetal link. Therefore, integrates (i) the merits commercially available monomethyl ether (OEGMA) i.e.,...
A cyclic hydrophilic moiety promotes stability of polymeric micelles significantly.
Polymeric prodrugs with precisely controlled drug loading content (DLC) and rapid intracellular destabilization generally require complicated chemistry that hinders large-scale manufacture. For this purpose, we reported in study a facile construction of reduction-sensitive amphiphilic polyprodrugs an anticancer drug, 10-hydroxycamptothecin (HCPT), hydrophilic poly(ethylene oxide) (PEG) moiety as the alternating building blocks multiblock copolymer using Cu(I)-catalyzed azide–alkyne...
We reported the synthesis of polymeric micelles with a dual-functional sheddable mPEG stealth to realize simultaneously tumor-triggered targeting and intracellular micelle destabilization for enhanced anticancer drug delivery.
An elegant integration of light-emitting segments into the structure polymeric delivery systems endows resulting self-assembled nanovehicles with diagnostic ability toward an enhanced therapeutic efficiency. A variety polyfluorene (PF)-based binary were designed and developed successfully, but PF-based ternary formulations remain rarely explored, likely due to synthetic challenge. To develop a universal synthesis strategy linear conjugated amphiphilic triblock copolymer for cancer...
Polymers with advanced topological architectures are promising materials for wide applications due to their structure-generated unique properties different from that of the linear analogues. The elegant integration stimuli-responsive polymers such can create novel virtues both moieties, thus a hot subject research fundamental and practical investigations. To fabricate cyclic brush polymer-based intelligent biomedical applications, herein, we designed synthesized thermo-sensitive...
Dendrimer with hyperbranched structure and multivalent surface is regarded as one of the most promising candidates close to ideal drug delivery systems, but clinical translation scale-up production dendrimer has been hampered significantly by synthetic difficulties. Therefore, there considerable scope for development novel polymer that can not only address drawbacks maintain its advantages. The reversible addition-fragmentation chain transfer self-condensing vinyl polymerization (RAFT-SCVP)...