Manganese (Mn) is an essential nutrient for metabolic functions, yet excessive exposure can lead to neurological disease in adults and neurodevelopmental deficits children. Drinking water represents one of the routes Mn exposure. Both natural enrichment from rocks soil, man-made contamination pollute groundwater that supplies drinking a substantial fraction U.S. population. Conventional methods monitoring are costly involve long turn-around time. Recent advancements electrochemical sensing,...

Seven new protopanaxatriol type saponins, 20S-sanchirhinosides A1 (1), A2 (2), A3 (3), A4 (4), A5 (5), and A6 (6), sanchirhinoside B (7) were obtained as minor constituents from the root extract of Panax notoginseng (Burkill, F. H. Chen), which showed protection effects against antimycin A induced mitochondrial oxidative stress. Their structures elucidated by chemical spectroscopic methods (IR, HRESI-TOF-MS, 1D 2D NMR). Among them, compounds 4, 6 7 significant protective A-induced L6 cell injury.

A cyclic hydrophilic moiety promotes stability of polymeric micelles significantly.

Lead (Pb) has long been acknowledged as a systemic toxicant, with pronounced health impacts observed even at low exposure levels, particularly in children. Adverse effects include diminished cognitive function, altered behavior, and developmental delays. Consequently, it is imperative to conduct regular monitoring of Blood Levels (BLLs). In this work, we report on an electrochemical sensor based screen-printed carbon electrode (SPCE) coated Nafion mesoporous (MC). The system uses simple...

The acute toxicity of mango leaves extract (MLE) at the maximal dose (18.4 g/kg) was studied in ICR mice and no abnormalities were detected during experiment. long‐term studies various doses MLE (100 mg/kg, 300 900 mg/kg) SD rats for 3 consecutive months revealed that, compared with control group, treated groups showed slight body weight increase higher fat weight; serum TG CHOL levels epididymis male a little higher; K + level female on low side but weights liver, kidney, adrenal gland high...

The extraordinary physiochemical properties of carbon nanotubes (CNTs) stimulated their wide application in biosensing research. Nanotube characteristics fast electron transport, large surface area, high strength, excellent catalytic activity and good chemical stability contribute to ultrasensitive, highly selective stable CNT biosensors. Among the various biosensors, field-effect transistor (FET) architecture has received tremendous attention due advantages performance, miniaturization,...

We present a smart catheter flow sensor for real-time, continuous, and quantitative measurement of regional cerebral blood using in situ temperature thermal conductivity compensation. The operates constant-temperature mode employs periodic heating cooling technique. This approach ensures zero drift provides highly reliable data with microelectromechanical system-based thin film sensors. developed has sensitivity 0.973 mV/ml/100 g/min the range from 0 to 160 ml/100 linear correlation...

Objective. Direct-current electrocorticography (DC-ECoG) allows a more complete characterization of brain states and pathologies than traditional alternating-current recordings (AC-ECoG). However, reliable recording DC signals is challenging because electrode polarization-induced potential drift, particularly at low frequencies for conducting materials. Further challenges arise as size decreases, since impedance increased the drift augmented. While microelectrodes have been investigated...

Over the past decades, tremendous progress has been advanced in preparation of hyperbranched polymers (HPs), especially for one-pot synthesis segmented HPs by using self-condensing vinyl polymerization based on controlled living radical techniques. However, fabrication polymeric prodrugs (HPPs) still requires multistep postpolymerization conjugations, which generally suffer from low and uncontrolled conjugation efficacy drug molecules due to steric hindrance, yields because synthesis,...

With the promising applications in artificial intelligence systems and wearable health care devices, great efforts have been devoted to develop advanced pressure sensors. Graphene-based materials are sensor due excellent electrical conductivity, outstanding mechanical properties large surface area. This review summarizes recent advances progress graphene graphene-based Perspectives challenges this exciting field also highlighted discussed.

Flexible pressure and thermal sensors are the critical parts of functional electronic skin prostheses robots, as well flexible catheter/devices for multimodal biomedical monitoring. In this paper, a polysilicon thin film was developed on polyimide substrate using aluminum induced crystallization process temperature sensing applications. The formation polycrystalline structure verified from film. Long term stability real-time tests were performed to evaluate potential application <italic...

A new intracranial pressure (ICP) sensor on polyimide lab-on-a-tube using exchanged polysilicon piezoresistive film has been designed, fabricated and successfully characterized in this work. Flexible (Kapton) was used as the substrate for a type microcatheter. Aluminum induced crystallization (AIC) process with low annealing temperature utilized development of sensing element membrane based sensor. The integrated shows linearity 0.996 sensitivity 0.17 mV/mmHg range 0~45 mmHg, which is very...

A micromachined blood flow sensor with in situ tissue temperature and thermal conductivity compensation was developed for the continuous quantitative measurement of intraparenchymal regional cerebral flow. The operates a constant-temperature mode employs periodic heating cooling technique. Thermal is realized by sampling peak current outputs at beginning period baseline variation during compensated an integrated sensor. This approach provides highly reliable data MEMS-based thin film...

This work reports on development of a novel smart catheter flow sensor (SCF) for continuous monitoring regional cerebral blood (CBF). The SCF employs periodic heating technique rather than and calibrates itself every 5 seconds. approach ensures zero drift long-term can provide reliable data with MEMS-based thin film sensors. In addition, it uses 4-wire configuration to eliminate lead wire effect ratiometric measurement deduce the resistance SCF. Hence, is more precise when compared...

A multifunctional lab-on-a-tube (LOT) probe for simultaneous in vivo neurochemical and electrophysiological activity measurements is presented. Developed heterostructured platinum/iridium oxide (Pt/IrOx) microelectrodes have shown a superior signal-to-noise ratio around 80 times slower polarization rate than platinum with the same surface area. Oxygen glucose biosensors been integrated to simultaneously detect their changes during cortical spreading depolarizations. The developed LOT shows...

In this work, we demonstrate accurate and precise measurement of manganese (Mn) concentration in human whole blood with indium tin oxide (ITO) electrode using square wave stripping voltammetry. While an essential trace metal for health, elevated levels Mn due to environmental or occupational exposure have been associated severe neuromotor dysfunction characterized by parkinsonism cognitive making the monitoring necessary. Pediatric populations are particularly susceptible given their...

This paper reports a high sensitive flexible and wearable pressure temperature sensor array with polysilicon thin film (PTF). PTF was developed on polyimide aluminum induced crystallization at low used as the sensing material for both sensors. The has sensitivity of 1.01 mV/ kPa resolution 100 Pa, 2.26 °C 0.1 °C. sensitivity, cross talk can be very applicable electronic skin robotic fingers, prostheses biomedical monitoring.

Creating different oxygen tensions at a microscale level can be beneficial for studies that investigate oxygen-dependent cellular behavior. Here we present novel, highly flexible, tension programmable microfluidic system (oPROMs) capable of generating various uniform without using complex device structures and multiple gas interconnections. The oPROMs is coated with mixture Glucose oxidase (GOX) Catalase (CAT) immobilized in chitosan matrix then covered by membranes thickness. high glucose...