A5029826552- Natural product bioactivities and synthesis
- Pancreatitis Pathology and Treatment
- Phytoestrogen effects and research
- Liver Disease Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Phytochemistry and Biological Activities
- Pharmacological Effects of Natural Compounds
- Phytochemicals and Antioxidant Activities
- Lipid metabolism and disorders
- Gout, Hyperuricemia, Uric Acid
- Natural Antidiabetic Agents Studies
- Ginseng Biological Effects and Applications
- Innovative Microfluidic and Catalytic Techniques Innovation
- Microfluidic and Capillary Electrophoresis Applications
- Polysaccharides and Plant Cell Walls
- Therapeutic Uses of Natural Elements
- Phagocytosis and Immune Regulation
- Seaweed-derived Bioactive Compounds
- Pediatric Hepatobiliary Diseases and Treatments
- Neonatal Health and Biochemistry
- Alcohol Consumption and Health Effects
- Analytical Chemistry and Chromatography
- Traditional and Medicinal Uses of Annonaceae
- Healthcare and Venom Research
- Apelin-related biomedical research
Dalian Medical University
2016-2025
First Affiliated Hospital of Dalian Medical University
2016-2025
Shenyang Pharmaceutical University
2011-2025
Northwest A&F University
2023-2024
Affiliated Zhongshan Hospital of Dalian University
2023
Michigan State University
2021
Harbin Institute of Technology
2004
A multicomponent quantification fingerprint based on HPLC coupled with diode array detection and electrospray ionization tandem mass spectrometry (HPLC-DAD-ESI/MS) technique has been established for the analysis of phenolic compounds in 12 samples originated from 5 different cultivars Chrysanthemum morifolium flowers China. Four caffeoylquinic acids 15 flavonoids capitulum were identified by comparing retention times ultraviolet spectra as well spectrum and/or matching empirical molecular...
Pancreatitis is an inflammatory disease that responsible for substantial morbidity and mortality, it can induce pancreatic necrosis starts within acinar cells in severe cases. Emodin, a pleiotropic natural product isolated from the Chinese herb Rheum palmatum L., has effective anti-inflammatory activities. In this paper, we investigated protective effects molecular mechanism of emodin against sodium taurocholate (STC)-induced injury vitro vivo; results showed could significantly alleviate...
Qing-Yi Recipe, a classic traditional Chinese medicine (TCM), is widely used for treating acute diseases of the abdomen, especially pancreatitis, efficacy which has been demonstrated in more than thirty clinical trials. However, in-vivo pharmacodynamic material basis this formula remains unclear. A sensitive and accurate method quantifying twenty-two potential bioactive constituents Recipe biological samples was developed using liquid chromatography-tandem mass spectrometry (LC-MS/MS), fully...
Acute pancreatitis (AP) is an aseptic inflammation characterized with annual incidence rate, and ~20% patients progressing to severe AP (SAP) a high mortality rate. Although Qingyi decoction has been frequently used for SAP treatment over the past 3 decades in clinic, actual mechanism of its protective effects remains unknown. As major active ingredient decoction, emodin was selected present study investigate effect against acute rats through NOD‑like receptor protein (NLRP3) inflammasomes....
Background: Qing-Yi Decoction (QYD) is a classic precompounded prescription with satisfactory clinical efficacy on acute pancreatitis (AP). However, the chemical profile and overall molecular mechanism of QYD in treating AP have not been clarified. Methods: In present study, rapid, simple, sensitive reliable ultra-performance liquid chromatography coupled quadrupole time-of-flight mass spectrometry (UHPLC-QTOF-MS)-based was first established. An integration strategy network pharmacology...
The purpose of the study is to compare alkaloid profile Uncaria rhynchophylla hooks and leaves. Ten oxindole alkaloids four glycosidic indole were identified using HPLC-diode array detection (DAD) or LC-atmospheric pressure chemical ionization (APCI)-MS method, a HPLC-UV method for simultaneous quantification major was validated. are characterized by high levels rhynchophylline (R), isorhynchophylline (IR), corynoxeine (C) isocorynoxeine (IC), while leaves contained level two vincoside...
An ultra performance liquid chromatography (UPLC) coupled with quadrupole time-of-flight mass spectrometry (QTOF/MS) method is established for the rapid analysis of isoflavones, saponins and flavones in 16 samples originated from flowers Pueraria lobata P. thomsonii. A total 25 13 3 were identified by co-chromatography sample extract authentic standards comparing retention time, UV spectra, characteristic molecular ions fragment those standards, or tentatively MS/MS determination along Mass...
Yin-Chen-Hao Tang (YCHT) is a classical Chinese medicine compound that has long history of clinical use in China for the treatment inflammatory diseases. However, efficacy and mechanisms YCHT severe acute pancreatitis (SAP) are not known. The current study investigated pharmacological properties against SAP its underlying mechanisms. A computational prediction potential targets was initially established based on network pharmacology simulation. model suggested attenuated progress by...
Abstract A novel open‐tubular capillary electrochromatography column coated with β ‐cyclodextrin was prepared using the sol‐gel technique. In approach, owing to three‐dimensional network of and strong chemical bond between stationary phase surface columns, good chromatographic characteristics unique selectivity in separating enantiomers were shown. The influences inner diameter, coating time, organic modifier, buffer pH, concentration on separation investigated. sol‐gel‐coated has shown...
Kakkalide is a major isoflavonoid from the flowers of Pueraria lobata (Willd.) Ohwi, possessing protective effect against ethanol-induced intoxication and hepatic injury. The metabolism kakkalide was investigated in rats. Thirteen metabolites were isolated by using solvent extraction repeated chromatographic methods identified spectroscopic including UV, IR, mass spectrometry, NMR, circular dichroism experiments. Four new compounds as irisolidone-7-<i>O</i>-glucuronide (M-1),...