A5028526313- Pancreatitis Pathology and Treatment
- Pancreatic and Hepatic Oncology Research
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Cancer Immunotherapy and Biomarkers
- Lipid metabolism and disorders
- RNA modifications and cancer
- Phagocytosis and Immune Regulation
- Apelin-related biomedical research
- Cancer, Lipids, and Metabolism
- Rheumatoid Arthritis Research and Therapies
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Flavonoids in Medical Research
- Cardiac Arrest and Resuscitation
- Kruppel-like factors research
- Circular RNAs in diseases
- Biomedical and Engineering Education
- Epigenetics and DNA Methylation
- Antibiotic Resistance in Bacteria
- Simulation-Based Education in Healthcare
- Extracellular vesicles in disease
- Heme Oxygenase-1 and Carbon Monoxide
- Cancer Genomics and Diagnostics
- Liver Disease Diagnosis and Treatment
- Innovative Teaching Methods
Anhui University of Traditional Chinese Medicine
2024-2025
Huazhong University of Science and Technology
2025
Dalian Medical University
2015-2024
First Affiliated Hospital of Dalian Medical University
2016-2024
Ministry of Education of the People's Republic of China
2024
Weatherford College
2022
Juntendo University
2019-2022
Juntendo University Hospital
2022
University of Missouri
2021
Dalian University
2016-2019
The extracellular matrix (ECM) is a vital component of the tumor microenvironment, which interplays with stromal and cells to stimulate capacity cancer proliferate, migrate, invade, undergo angiogenesis. Nevertheless, crucial functions ECM-related genes (ECMGs) in pancreatic adenocarcinoma (PAAD) have not been systematically evaluated. Hence, comprehensive evaluation ECMGs required pan-cancer, especially PAAD. First, pan-cancer overview was explored through integration expression profiles,...
Pancreatitis is an inflammatory disease that responsible for substantial morbidity and mortality, it can induce pancreatic necrosis starts within acinar cells in severe cases. Emodin, a pleiotropic natural product isolated from the Chinese herb Rheum palmatum L., has effective anti-inflammatory activities. In this paper, we investigated protective effects molecular mechanism of emodin against sodium taurocholate (STC)-induced injury vitro vivo; results showed could significantly alleviate...
Rheumatoid arthritis (RA) is a chronic autoimmune disease that primarily manifests with symptoms such as heat and toxin. However, the key components molecular mechanisms of Zhizi Baipi decoction (ZBD) in treatment RA are still unclear. The study aimed to explore mechanism action ZBD for treating through ingredient analysis, network pharmacology, experimental validation. chemical constituents were identified by ultra-high performance liquid chromatography coupled Q-TOF-mass spectrometry...
Objective: To explore baseline clinical and imaging characteristics of children with neonatal arterial ischaemic stroke based on their long-term motor function prognoses. Methods: A retrospective cohort study was conducted. Clinical data, including magnetic resonance (MRI) electroencephalogram (EEG) findings, were collected from 31 neonates diagnosed ischemic admitted to the Department Neonataology, Maternal Child Health Hospital Hubei Province between January 2015 December 2019. Unified...
Recent studies have proven that the overall pathophysiology of pancreatitis involves not only pancreatic acinar cells but also duct cells, however, contribution in homeostasis is poorly known and molecular mechanisms leading to insult acute (AP) are unclear. Our previous work showed S100A9 protein level was notably increased AP rat pancreas through iTRAQ-based quantitative proteomic analysis. Therefore, we investigated actions injured on S100A9-related effects underlying pathology present...
The development of multidrug resistance is a major problem in the treatment pathogenic microorganisms by distinct antimicrobial agents. Characterizing genetic variation among plasmids from different bacterial species or strains key step towards understanding mechanism virulence and their evolution.We applied deep sequencing approach to 206 clinical Klebsiella pneumoniae collected 2002 2008 understand plasmids, reveal dynamic change drug over time. First, we sequenced three (70 Kb, 94 147 Kb)...
Acute pancreatitis (AP) is an aseptic inflammation characterized with annual incidence rate, and ~20% patients progressing to severe AP (SAP) a high mortality rate. Although Qingyi decoction has been frequently used for SAP treatment over the past 3 decades in clinic, actual mechanism of its protective effects remains unknown. As major active ingredient decoction, emodin was selected present study investigate effect against acute rats through NOD‑like receptor protein (NLRP3) inflammasomes....
The intestinal barrier injury caused by severe acute pancreatitis (SAP) can induce enterogenous infection, further aggravating the inflammatory reactions and immune responses. This study aimed to test hypothesis that emodin protects function is involved in response SAP.The network pharmacology was established using Swiss target prediction pathway enrichment analysis. SAP mice model induced cerulein (50 μg/kg) lipopolysaccharide (10 mg/kg) hyperstimulation. pharmacological effect of treating...
Stomach adenocarcinoma (STAD) is a malignant tumor with high histological heterogeneity. However, the potential mechanism of STAD tumorigenesis remains to be elucidated. The purpose our research was identify candidate genes associated diagnosis, progression, prognosis, and immunotherapeutic targets STAD. Based on samples from GSE28541 dataset, weighted gene co-expression network analysis revealed 16 modules related stage grade. salmon module emerged as most relevant (cor = 0.34), functional...
Introduction The coronavirus disease 2019 (COVID-19), emerged in late 2019, was caused by severe acute respiratory syndrome 2 (SARS-CoV-2). risk factors for idiopathic pulmonary fibrosis (IPF) and COVID-19 are reported to be common. This study aimed determine the potential role of differentially expressed genes (DEGs) common IPF COVID-19. Materials methods Based on GEO database, we obtained DEGs from one SARS-CoV-2 dataset five datasets. A series enrichment analysis were performed identify...
Endoplasmic reticulum stress (ERS) is caused by the accumulation of intracellular misfolded or unfolded proteins and associated with cancer development. In this study, pan-cancer analysis revealed complex genetic variations, including copy number variation, methylation, somatic mutations for ERS-related genes (ERGs) in 33 kinds cancer. Consensus clustering divided pancreatic (PC) patients from TCGA GEO databases into two subtypes: ERGcluster A B. Compared A, B had a more active ERS state...
Yin-Chen-Hao Tang (YCHT) is a classical Chinese medicine compound that has long history of clinical use in China for the treatment inflammatory diseases. However, efficacy and mechanisms YCHT severe acute pancreatitis (SAP) are not known. The current study investigated pharmacological properties against SAP its underlying mechanisms. A computational prediction potential targets was initially established based on network pharmacology simulation. model suggested attenuated progress by...
Severe acute pancreatitis (SAP) results in high mortality. This is partly because of early multiple organ dysfunction syndromes that are usually caused by systemic inflammatory response syndrome (SIRS). Many studies have reported the beneficial effects emodin against SAP with SIRS. However, exact mechanism underlying effect remains unclear. study was designed to explore protective and mechanisms SIRS rats SAP. In present study, cytosolic Ca 2+ levels, calpain 1 activity, expression levels...
Background: GDP Dissociation inhibitor 2 (GDI2) gene has been correlated with some important biological processes in a variety of cancers, whereas the role GDI2 hepatocellular carcinoma (HCC) is ill-defined. We aimed to demonstrate relationship between and HCC based on The Cancer Genome Atlas (TCGA) data mining. Methods: expression was compared cancer normal tissues 371 patients collected from TCGA-LIHC, verified cell lines. Gene set enrichment analysis (GSEA) applied annotate function GDI2....
// Shi-Lin Xia 1,* , Mo-Li Wu Hong Li 1 Jia-Hui Wang Nan-Nan Chen 2 Xiao-Yan Qing-You Kong Zheng Sun and Jia Liu Liaoning Laboratory of Cancer Genetics Epigenetics Department Cell Biology, College Basic Medical Sciences, Dalian University, Dalian, China Hematology, PLA 210 Hospital, * These authors contributed equally to this work Correspondence to: Liu, email: Keywords : Glioblastoma, All-trans retinoic acid, Chemosensitivity, CRABP-II, FABP5 Received September 24, 2014 Accepted January 05,...
Abstract Lung cancer is a very aggressive characterized with molecular heterogeneities in different subtypes, including lung adenocarcinoma and squamous cell carcinoma. However, few related signatures have been established for the treatment of subtypes. Polo‐like kinase (PLK) family crucial regulator during division. Aberrant genetic epigenetic alteration PLK members plays controversial role among cancers. In this study, we performed an analysis transcriptional protein expression to identify...
Skin cutaneous melanoma (SKCM) is a common cancer of which mortality increasing continuously. Our study conducted series analyses on the clinical significance Serine/threonine kinase 17B (STK17B) in SKCM to provide new biomarker for diagnosis and treatment. The RNA-sequence data were obtained from Cancer Genome Atlas Genotype-Tissue Expression databases. 468 patients divided into STK17B high- low-expression groups analyzed by Bioconductor package identify differential expressed genes. R...