A5112115893- RNA modifications and cancer
- Advancements in Battery Materials
- Lung Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Advanced DC-DC Converters
- Lung Cancer Treatments and Mutations
- Cardiac electrophysiology and arrhythmias
- Advanced Battery Technologies Research
- Multilevel Inverters and Converters
- Cancer-related Molecular Pathways
- T-cell and B-cell Immunology
- Radiomics and Machine Learning in Medical Imaging
- Silicon Carbide Semiconductor Technologies
- Covalent Organic Framework Applications
- Per- and polyfluoroalkyl substances research
- Viral Infections and Vectors
- Animal Nutrition and Physiology
- Ion channel regulation and function
- RNA and protein synthesis mechanisms
- Advanced Battery Materials and Technologies
- Landslides and related hazards
- Immune Cell Function and Interaction
- Viral Infections and Outbreaks Research
- Advanced Control Systems Design
- Enterobacteriaceae and Cronobacter Research
Huazhong University of Science and Technology
2023-2025
Tongji Hospital
2023-2025
Dalian University of Technology
2022-2024
Lanzhou University
2023-2024
Northwest A&F University
2024
First Affiliated Hospital of Dalian Medical University
2023-2024
Dalian Medical University
2023-2024
Xi'an Technological University
2023
Guangxi Normal University
2022
Beijing Transportation Research Center
2020
Abstract In a genome-wide screen for putative tumor suppressor genes, the EBF3 locus on human chromosome 10q26.3 was found to be deleted or methylated in 73% of examined cases brain tumors. is expressed normal but silenced Therefore, it suggested that suppressor. However, remains unknown whether inactivation also occurs other types tumors and what functions underlie EBF3-mediated suppression. We show here expression resulted cell cycle arrest apoptosis. The cyclin-dependent kinase inhibitors...
As the primary molecular target, there is still a gap between peroxisome proliferator-activated receptors (PPARs) regulation and adverse health effects caused by per- polyfluoroalkyl substances (PFASs). The of PFASs on cellular differentiation regulated PPARs likely significant given association exposure with obesity decreased bone density. Human mesenchymal stem cells (hMSCs) were used as an in vitro model to assess roles PPAR subtypes multipotent hMSCs affected perfluorooctanesulfonate...
The development of multidrug resistance is a major problem in the treatment pathogenic microorganisms by distinct antimicrobial agents. Characterizing genetic variation among plasmids from different bacterial species or strains key step towards understanding mechanism virulence and their evolution.We applied deep sequencing approach to 206 clinical Klebsiella pneumoniae collected 2002 2008 understand plasmids, reveal dynamic change drug over time. First, we sequenced three (70 Kb, 94 147 Kb)...
Background— Single-nucleotide polymorphisms (SNPs) within the regulatory β2 subunit of voltage-gated calcium channel ( CACNB2 ) may contribute to variable treatment response antihypertensive drugs and adverse cardiovascular outcomes. Methods Results— SNPs in from 60 ethnically diverse individuals were identified characterized. Three common (rs2357928, rs7069292, rs61839258) a genome-wide association study-identified intronic SNP (rs11014166) genotyped for clinical study 5598 hypertensive...
Genome-wide association studies have identified genetic markers in kallikrein-related peptidase 3 (KLK3) associated with prostate cancer. However, some of these are also prostate-specific antigen (PSA) levels, so it is unclear whether the polymorphisms causal or if risk solely due to detection bias through PSA screening. a biologically active serine protease, cleaving insulin-like growth factor-binding protein. We examined single-nucleotide (SNPs) KLK3 cancer risk, disease-specific survival...
In normal cells p53 activity is tightly controlled and MDM2 a known negative regulator. Here we show that via its acidic domain, Daxx binds to the COOH-terminal domain of p53, whose positive charges are critical for this interaction, as Lys Arg mutations preserved, but Ala or Ser Glu abolished Daxx-p53 interaction. These results thus implicate acetylation phosphorylation in regulating binding Daxx. Interestingly, whereas did not bind assessed by immunoprecipitation, expression restored...
Dabie Banda virus (DBV), a tick-borne pathogen, was first identified in China 2009 and causes profound symptoms including fever, leukopenia, thrombocytopenia multi-organ dysfunction, which is known as severe fever with syndrome (SFTS). In the last decade, global incidence mortality of SFTS increased significantly, especially East Asia. Though previous studies provide understandings clinical immunological characteristics development, comprehensive insight antiviral immunity response still...
The dynamic deformation characteristics of lightweight soil were studied using consolidated-undrained triaxial tests to predict its non-linear stress and strain behaviour under a traffic load. results showed that the influence confining pressure on attenuation shear modulus ratio became significant with increasing expanded polystyrene (EPS) particle content or cement content. curve was evaluated Davidenkov model parameters, A, B γ 0 . It proved parameter A mostly affected by EPS pressure,...
Background and AimsThe performance of neurodegenerative biomarkers—neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), tau, ubiquitin carboxy-terminal hydrolase L1 (UCHL1)—in diagnosing minimal hepatic encephalopathy (MHE) has not been systematically evaluated, simultaneously, nor have their associations with the development overt (OHE). This study aimed to evaluate plasma NfL, GFAP, UCHL1 in MHE predicting OHE Chinese patients cirrhosis.
Sodium p-perfluorous nonenoxybenzenesulfonate (OBS) is a novel alternative to perfluorooctane sulfonate (PFOS), with environmental health risks largely unknown. The present study aims unravel the adipogenesis effects and underlying molecular initiating events of OBS, which are crucial for understanding predicting its adverse outcome. In undifferentiated human mesenchymal stem cells (hMSCs), exposure 1-100 nM OBS 7 days stimulated reactive oxygen species production. subsequent multipotent...
Abstract The ongoing epidemic of SARS‐CoV‐2 is taking a substantial financial and health toll on people worldwide. Assessing the level duration neutralizing antibody (Nab) would provide key information for government to make sound healthcare policies. Assessed at 3‐, 6‐, 12‐, 18‐month postdischarge, we described temporal change IgG levels in 450 individuals with moderate critical COVID‐19 infection. Moreover, data imputation framework combined novel deep learning model was implemented...
Fragile X syndrome (FXS) is the most common inherited cause of intellectual disabilities and second after Down syndrome. FXS an X-linked disorder due to a full mutation CGG triplet repeat FMR1 gene which codes for protein that crucial in synaptogenesis maintaining functions extracellular matrix-related proteins, key development normal neuronal connective tissue including collagen. In addition neuropsychiatric behavioral problems, individuals with show physical features suggestive loose skin...
Abstract An N‐doped porous carbon (NPC) with structure was successfully prepared by a one‐step calcination method. The NPC its abundant modified active functional groups used in adsorption experiments, showing that the capacity of for Pb 2+ up to 179.86 mg g −1 at pH 5. It displayed fast kinetic rate and high selective cyclic capacities. mechanism consisted cationic‐ π interactions electrostatic attraction. Thus, developed has potential application removal from wastewater, due excellent...