A5029085127- Growth Hormone and Insulin-like Growth Factors
- Hepatitis B Virus Studies
- Liver Disease Diagnosis and Treatment
- Diabetes and associated disorders
- Hypothalamic control of reproductive hormones
- Birth, Development, and Health
- Immune Cell Function and Interaction
- Hepatitis C virus research
- COVID-19 Clinical Research Studies
- Metabolism and Genetic Disorders
- Pancreatic function and diabetes
- Sexual Differentiation and Disorders
- Diabetes Management and Research
- Animal Virus Infections Studies
- Lipid metabolism and disorders
- SARS-CoV-2 and COVID-19 Research
- RNA modifications and cancer
- Neonatal Respiratory Health Research
- Ovarian function and disorders
- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Pregnancy and preeclampsia studies
- Childhood Cancer Survivors' Quality of Life
- Mitochondrial Function and Pathology
- interferon and immune responses
Tongji Hospital
2016-2025
Huazhong University of Science and Technology
2016-2025
Sichuan University
2025
West China Hospital of Sichuan University
2025
Zhongshan People's Hospital
2025
China Academy of Engineering Physics
2024
Dalian Medical University
2007-2023
Chongqing Medical University
2007-2023
Second Affiliated Hospital of Chongqing Medical University
2007-2023
Zhuhai Institute of Advanced Technology
2023
BACKGROUND. Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome 2 (SARS-CoV-2) emerged in Wuhan, and is now becoming a global threat. We aimed to delineate compare the immunological features moderate COVID-19.
Abstract Objective To delineate the clinical characteristics of patients with coronavirus disease 2019 (covid-19) who died. Design Retrospective case series. Setting Tongji Hospital in Wuhan, China. Participants Among a cohort 799 patients, 113 died and 161 recovered diagnosis covid-19 were analysed. Data collected until 28 February 2020. Main outcome measures Clinical laboratory findings obtained from electronic medical records data collection forms. Results The median age deceased (68...
Modern humans have occupied almost all possible environments globally since exiting Africa about 100,000 years ago. Both behavioral and biological adaptations contributed to their success in surviving the rigors of climatic extremes, including cold, strong ultraviolet radiation, high altitude. Among these environmental stresses, high-altitude hypoxia is only condition which traditional technology incapable mediating its effects. Inhabiting at >3,000-m plateau, Tibetan population provides a...
<h3>Abstract</h3> <h3>Objective</h3> To estimate the incidence of type 1 diabetes in all age groups China during 2010-13. <h3>Design</h3> Population based, registry study using data from multiple independent sources. <h3>Setting</h3> National registration system 505 hospitals providing care, and communities patients with 13 areas across China, covering more than 133 million person years at risk, approximately 10% whole population. <h3>Participants</h3> 5018 people ages newly diagnosed...
Abstract Background Since late December, 2019, an outbreak of pneumonia cases caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, and continued to spread throughout China across globe. To date, few data on immunologic features Coronavirus Disease 2019 (COVID-19) have been reported. Methods In this single-centre retrospective study, a total 21 patients with who were laboratory-confirmed be infected SARS-CoV-2 Wuhan Tongji hospital included from Dec 19,...
This International Consensus Guideline was developed by experts in the field of small for gestational age (SGA) 10 pediatric endocrine societies worldwide. A consensus meeting held and 1300 articles formed basis discussions. All voted about strengths recommendations. The guideline gives new clinically relevant insights into etiology short stature after SGA birth, including novel knowledge (epi)genetic causes. Further, it presents long-term consequences birth also reviews treatment options,...
In Brief One of seven neonates born to women with symptomatic coronavirus 2019 (COVID-19) infection tested positive for the and was asymptomatic.
The Growth Hormone (GH) Research Society (GRS) convened a workshop to address important issues regarding trial design, efficacy, and safety of long-acting growth hormone preparations (LAGH).A closed meeting 55 international scientists with expertise in GH, including pediatric adult endocrinologists, basic scientists, regulatory participants from the pharmaceutical industry.Current literature was reviewed for gaps knowledge. Expert opinion used suggest studies required potential efficacy...
自2019年12月中旬以来，武汉市暴发新型冠状病毒感染的肺炎流行，疫情很快扩散到全国各地以及境外国家，形势严峻。在本次重大突发疫情中，儿童确诊病例数占比很小，但随着疫情高峰及更多地区开展病原检测，儿童感染例数有较明显增多趋势，应予以高度重视。本文将从儿科医生的角度，重点就儿童病例的流行病学特征与防控措施、临床疾病特点与转归、诊断标准及治疗等方面进行讨论，并提出相应建议。.
Although it is widely believed that China facing a major shortage of pediatricians, the real situation current national status pediatric human resources and their working conditions has not been evaluated to date.We administered survey 54 214 hospitals from all 31 provinces in mainland 2015 2016. Hospital directors secondary tertiary with services random sample (10%) primary provided information on number pediatricians educational levels, specialties, workloads, dropout rates, other hospital...
The functions of fibrinogen-like protein 2 (fgl2) have been studied in many inflammatory and neoplastic diseases, but the role fgl2 nonalcoholic fatty liver disease has not yet elucidated. In this study, we sought to investigate pathogenesis steatohepatitis (NASH).
Follow-up study of coronavirus disease 2019 (COVID-19) survivors has rarely been reported. We aimed to investigate longitudinal changes in the characteristics COVID-19 after discharge.A total 594 discharged from Tongji Hospital Wuhan February 10 April 30, 2020 were included and followed up until May 17, 2021. Laboratory radiological findings, pulmonary function tests, electrocardiogram, symptoms signs analyzed.257 (51.2%) patients had at least one symptom 3 months post-discharge, which...
Functional cure can be sustained in a proportion of patients with chronic hepatitis B (CHB) who lose surface antigen (HBsAg) after pegylated interferon alpha (Peg-IFN-ɑ)-based treatment. In this study, we aimed to identify biomarkers associated durable functional and dissect potential immunological mechanisms.Of 257 nucleos(t)ide analogue-suppressed CHB the ANCHOR 80 randomly assigned 96-week Peg-IFN-α-based therapy 24-week off-treatment follow-up were included parallel study. Virologic...
Abstract Autism spectrum disorder (ASD) is a neurological associated with brain inflammation. The underlying mechanisms could be attributed to the activation of PI3K signaling in inflamed ASD. Multiple studies highlight role GRPR regulating ASD like abnormal behavior and enhancing signaling. However, molecular mechanism by which regulates neurons individuals still unclear. In this study, we utilized maternal immune model investigate effects on mice. We used HT22 cells without examine impact...
The role of liver NK cells in virus-induced severe viral hepatitis and, subsequently, hepatic failure is not well defined. In this study, we investigated the development hepatocyte necrosis fulminant (FHF) and acute-on-chronic (ACLF) because infection. A mouse model FHF induced by murine virus strain 3 (MHV-3) was used to study cells. Samples from patients with B virus-related ACLF (HBV-ACLF) were examined. After MHV-3 infection, number livers BALB/cJ mice increased markedly, peaked at 48 h...
OBJECTIVES: To determine the current prevalence and mean ages of onset pubertal characteristics in healthy urban Chinese girls. METHODS: A cross-sectional study sexual maturation girls was conducted 9 representative cities eastern, western, southern, northern parts central region China between 2003 2005. At examination, stages breast pubic hair development were rated on 3 through 19.83 years age, height weight also recorded. Data menses collected by status quo method. Probit analysis used to...
We describe current pubertal development in healthy urban Chinese boys. A cross-sectional study of the 18 807 boys aged from 3.50 to 18.49 years was conducted between 2003 and 2005. Testicular volume evaluated with a Prader orchidometer. Pubic hair assessed according Tanner method. Data on spermarche were collected using status quo Probit analysis used calculate median age 95% CI at different stages testicular development, pubic spermarche. By 9, 12.99% had 4 mL or greater. The onset puberty...
We assessed the efficacy and safety of a weekly pegylated human growth hormone (PEG-rhGH) (Jintrolong) vs daily rhGH for children with deficiency (GHD).Phase II III, multicenter, open-label, randomized controlled trials.108 343 treatment-naive GHD from 6 hospitals in China were enrolled phase III studies respectively. Patients study 1:1:1 to Jintrolong (0.1 mg/kg/week PEG-rhGH complex), (0.2 complex) or (0.25 mg/kg/week) 25 weeks. 2:1 ratio The primary endpoint both was height velocity (HV)...
Background and Aims A novel bioactive peptide, mitochondrial-derived peptide (MOTS-c), has recently attracted attention as a potential prevention or therapeutic option for obesity type 2 diabetes mellitus (T2DM). MOTS-c profiles have not yet been reported in human T2DM. We aimed to determine circulating levels explore the association between various metabolic parameters. Methods In this case-control study, 40 obese children adolescents (27 males) 57 controls (40 were recruited Hubei Province...
<b><i>Background:</i></b> Circulating asprosin is a newly discovered adipokine that triggers the release of hepatic glucose stores and increases appetite. Asprosin levels are elevated in adult obese men as well mice, reductions protect against hyperinsulinism associated with metabolic syndrome mice diet-induced obesity, which indicates potential therapeutic role obesity type 2 diabetes. <b><i>Objectives:</i></b> Few data on children available,...