A5004925482- Cancer-related Molecular Pathways
- Zebrafish Biomedical Research Applications
- Microtubule and mitosis dynamics
- RNA modifications and cancer
- MicroRNA in disease regulation
- Lung Cancer Diagnosis and Treatment
- Cell death mechanisms and regulation
- Mesenchymal stem cell research
- Hip disorders and treatments
- RNA Interference and Gene Delivery
- Bone fractures and treatments
- Virus-based gene therapy research
- Bioactive Compounds and Antitumor Agents
- Echinoderm biology and ecology
- Epigenetics and DNA Methylation
- Bone and Joint Diseases
- Nerve injury and regeneration
- Viral Infections and Vectors
- Chemokine receptors and signaling
- Cancer Cells and Metastasis
- Reproductive Biology and Fertility
- Telomeres, Telomerase, and Senescence
- Phytochemical compounds biological activities
- Ultrasound and Hyperthermia Applications
- Anatomy and Medical Technology
Guiyang Medical University
2015-2024
Affiliated Hospital of Guizhou Medical University
2015-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2024
Zunyi Medical University
2020-2023
Guiyang University
2020
Although it is widely believed that China facing a major shortage of pediatricians, the real situation current national status pediatric human resources and their working conditions has not been evaluated to date.We administered survey 54 214 hospitals from all 31 provinces in mainland 2015 2016. Hospital directors secondary tertiary with services random sample (10%) primary provided information on number pediatricians educational levels, specialties, workloads, dropout rates, other hospital...
To evaluate the effect of 3D printing in treating trimalleolar fractures and its roles physician-patient communication, thirty patients with were randomly divided into assisted-design operation group (Group A) no-3D B). In Group A, was used by surgeons to produce a prototype actual fracture guide surgical treatment. All underwent open reduction internal fixation. A questionnaire designed for doctors verify verisimilitude effectiveness 3D-printed prototype. Meanwhile, time intraoperative...
In this study, we developed a simple and sensitive approach for EBV detection. The assay attained high specificity in the presence of various bacteria applicability Burkitt's lymphoma serum samples.
Summary Type 2 diabetes mellitus (T2 DM ) is caused by insulin resistance and characterized progressive pancreatic β ‐cell dysfunction. This articles reviews the application limitations of currently approved oral drugs for treatment T2 . Data were retrieved from literature well‐recognized drug‐related databases. Although lifestyle modifications metformin are cornerstones initial management , there an increasing array second‐ third‐line pharmacological agents, including sulphonylureas,...
Abstract: Pancreatic cancer is the most aggressive worldwide with poor response to current therapeutics. Alisertib (ALS), a potent and selective Aurora kinase A inhibitor, exhibits anticancer effects in preclinical clinical studies; however, effect underlying mechanism of ALS pancreatic treatment remain elusive. This study aimed examine on cell growth, autophagy, epithelial-to-mesenchymal transition (EMT) delineate possible molecular mechanisms human PANC-1 BxPC-3 cells. The results showed...
Abstract: Plumbagin (PLB), an active naphthoquinone compound, has shown potent anticancer effects in preclinical studies; however, the effect and underlying mechanism of PLB for treatment pancreatic cancer is unclear. This study aimed to examine cell killing investigate human PANC-1 BxPC-3 cells. The results showed that exhibited inducing on cycle arrest cells via modulation regulators including CDK1/CDC2, cyclin B1, D1, p21 Waf1/Cip1, p27 Kip1, p53. concentration- time-dependently increased...
Background: It was recently reported that lncRNA FBXL19 antisense RNA 1 (FBXL19-AS1) is a novel tumor-promoting contributes to tumor progression by sponging miRNAs. However, the expression and function of FBXL19-AS1 in osteosarcoma (OS) have not been investigated. Methods: Cell proliferation assessed CCK-8 colony formation assays, while cell migration invasion were using wound healing transwell respectively. Quantitative reverse transcriptase PCR immunofluorescence used detect level...
Glial cell line-derived neurotrophic factor (GDNF) is the most potent neuroprotective agent tested in cellular and animal models of Parkinson's disease (PD). However, CNS delivery GDNF restricted by blood-brain barrier (BBB). Using total body irradiation as transplant preconditioning, we previously reported that hematopoietic stem (HSC) transplantation (HSCT)-based macrophage-mediated gene therapy could deliver to brain prevent degeneration nigrostriatal dopamine (DA) neurons an acute murine...
Accumulating research has documented that microRNA-21 (miR-21) plays an important role in the development of human colorectal carcinoma (CRC). Our recent work also showed antisense oligonucleotides (ASOs) against miR-21 can impair growth CRC cells vitro. However, potential gene therapy remains to be fully elucidated. Here, we further observed effect ASOs on and metastasis vivo using a xenograft model CRC. We found could effectively inhibit vivo, accompanied by downregulated expression...
This paper reviews the human skeletal dynamics model employed in figure skating pose analysis. The prevailing contemporary technological framework is predicated on integration of artificial observation assistance, miniature wearable unit data, and dynamic recognition, a suite technical methodologies. assesses tools advantages disadvantages these three approaches, with focus neural network-based multi-fusion 3D recognition. Finally, study offers discussion potential for hardware software...
Abstract: Tongue squamous cell carcinoma (TSCC) is the most common malignancy in oral and maxillofacial tumors with highly metastatic characteristics. Plumbagin (5-hydroxy-2-methyl-1, 4-naphthoquinone; PLB), a natural naphthoquinone derived from roots of Plumbaginaceae plants, exhibits various bioactivities, including anticancer effects. However, potential molecular targets underlying mechanisms PLB treatment TSCC remain elusive. This study employed stable isotope labeling by amino acids...
Abstract: Plumbagin (PLB) has exhibited a potent anticancer effect in preclinical studies, but the molecular interactome remains elusive. This study aimed to compare quantitative proteomic responses PLB treatment human prostate cancer PC-3 and DU145 cells using approach of stable-isotope labeling by amino acids cell culture (SILAC). The data were finally validated Western blot assay. First, bioinformatic analysis predicted that could interact with 78 proteins involved proliferation...
Vanillin (4-hydroxy-3-methoxybenzaldehyde), a food additive with rich milk flavor, is commonly used in the food, beverage and cosmetic industries. However, excessive consumption of vanillin may cause liver kidney damage. Therefore, methods for detecting controlling level especially infant powder, have important practical significance. In this study, we established colorimetric assay detection. The detection was performed under high-temperature acidic conditions, which can induce reaction...
Abstract Background Colorectal adenocarcinoma (CRA) is one of the leading causes cancer-related deaths in world. Long non-coding RNAs (lncRNAs) have been implicated to be effective regulators disease course human cancers, including CRA. Small nucleolar RNA host gene 17 (SNHG17) belongs lncRNAs, and it has reported breast cancer gastric cancer. However, function SNHG17 its mechanism CRA progression remain largely unknown. In this study, we attended shedding some light on role Methods RT-qPCR...
Novel targeting of PEGylated liposomes for codelivery TGF-β1 siRNA and four antitubercular drugs to human macrophages the treatment mycobacterial infection: a quantitative proteomic study Ning-Kui Niu,1–3 Juan-Juan Yin,3 Yin-Xue Yang,4 Zi-Li Wang,1 Zhi-Wei Zhou,3 Zhi-Xu He,5 Xiao-Wu Chen,6 Xueji Zhang,7 Wei Duan,8 Tianxin Yang,9 Shu-Feng Zhou3 1Department Orthopedics, General Hospital Tianjin Medical University, Tianjin, 2Department Spinal Surgery, Ningxia Yinchuan, Ningxia, People's...